Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Luo, Ran ^a   Wang, Xiongwei ^a   Dong, Yuanxun ^a   Wang, Lei ^a   Tian, Chunlei ^a  

^a CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

Glioma; p53; Protease activated receptor 2; Signal transducer and activator of transcription 3; Tryptase

Indexed keywords

PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 2; STAT3 PROTEIN; TRYPTASE; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CASE REPORT; CELL ACTIVATION; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MALE; MAST CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR INVASION; WESTERN BLOTTING; BIOSYNTHESIS; ENZYME ACTIVATION; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; ENZYME ACTIVATION; GLIOBLASTOMA; HUMANS; MOLECULAR TARGETED THERAPY; RECEPTOR, PAR-2; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84898755486     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-21-25     Document Type: Article

References (30)

1. Glioblastoma multiforme: a review of where we have been and where we are going. Adamson C, Kanu OO, Mehta AI, Di C, Lin N, Mattox AK, Bigner DD, Expert Opin Investig Drugs 2009 18 1061 1083 10.1517/13543780903052764 19555299
2. Emerging insights into the molecular and cellular basis of glioblastoma. Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, Chin L, Hahn WC, Genes Dev 2012 26 756 784 10.1101/gad.187922.112 22508724
3. Apoptosis and necrosis: Detection, discrimination and phagocytosis. Krysko DV, Vanden Berghe T, D'Herde K, Vandenabeele P, Methods 2008 44 205 221 10.1016/j.ymeth.2007.12.001 18314051
4. Functional Regulatory Role of STAT3 in HPV16-Mediated Cervical Carcinogenesis. Shukla S, Mahata S, Shishodia G, Pandey A, Tyagi A, Vishnoi K, Basir SF, Das BC, Bharti AC, PLoS ONE 2013 8 67849 10.1371/journal.pone.0067849 23874455
5. Inflammation and type one diabetes. Bending D, Zaccone P, Cooke A, Int Immunol 2012 24 339 346 10.1093/intimm/dxs049 22447815
6. The value of miRNA in diagnosing thyroid cancer: A systematic review. Lodewijk L, Prins AM, Kist JW, Valk GD, Kranenburg O, Rinkes IH, Vriens MR, Cancer Biomarkers 2012 11 229 238 23248180
7. Thrombin signalling and protease-activated receptors. Coughlin SR, Nature 2000 407 258 264 10.1038/35025229 11001069
8. Tissue Factor Signals Airway Epithelial Basal Cell Survival via Coagulation and Protease-Activated Receptor Isoforms 1 and 2. Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW, Am J Respir Cell Mol Biol 2013 48 94 104 10.1165/rcmb.2012-0189OC 23065128
9. Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties. Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA, Daidone MG, Cancer Res 2005 65 5506 5511 10.1158/0008-5472.CAN-05-0626 15994920
10. Mast cells, angiogenesis and cancer. Ribatti D, Crivellato E, Adv Exp Med Biol 2011 716 270 288 10.1007/978-1-4419-9533-9-14 21713661
11. STAT3 as a therapeutic target for Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma. Ho Y, Tsao SW, Zeng M, Lui VW, Cancer Lett 2013 330 141 149 10.1016/j.canlet.2012.11.052 23220625
12. uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells. Malla RR, Gopinath S, Alapati K, Gorantla B, Gondi CS, Rao JS, Neuro-Oncol 2012 14 745 760 10.1093/neuonc/nos088
13. Mitochondrial gene expression in the human annulus: in-ávivo data from annulus cells and selectively harvested senescent annulus cells. Gruber HE, Watts JA, Hoelscher GL, Bethea SF, Ingram JA, Zinchenko NS, Hanley EN Jr, Spine J 2011 11 782 791 10.1016/j.spinee.2011.06.012 21784712
14. ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC, Cell Calcium 2011 50 261 269 10.1016/j.ceca.2011.05.015 21665274
15. Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy. Yuan CH, Filippova M, Duerksen-Hughes P, Viruses 2012 4 3831 3850 10.3390/v4123831 23250450
16. Mast cells in the brain: evidence and functional significance. Silver R, Silverman AJ, Vitković L, Lederhendler II, Trends Neurosci 1996 19 25 31 10.1016/0166-2236(96)81863-7 8787137
17. Degranulation, density, and distribution of mast cells in the rat thalamus: A light and electron microscopic study in basal conditions and after intracerebroventricular administration of nerve growth factor. Florenzano F, Bentivoglio M, J Comp Neurol 2000 424 651 669 10.1002/1096-9861(20000904)424: 4<651::AID-CNE7>3.0.CO;2-G 10931487
18. The majority of brain mast cells in B10.PL mice is present in the hippocampal formation. Hendrix S, Warnke K, Siebenhaar F, Peters EMJ, Nitsch R, Maurer M, Neurosci Lett 2006 392 174 177 10.1016/j.neulet.2005.09.029 16219422
19. Gonadal Steroids Regulate the Number and Activational State of Mast Cells in the Medial Habenula. Wilhelm M, King B, Silverman AJ, Silver R, Endocrinology 2000 141 1178 1186 10698195
20. Francois As. Mast Cells Are an Essential Component of Human Radiation Proctitis and Contribute to Experimental Colorectal Damage in Mice. Blirando K, Milliat F, Martelly I, Sabourin JC, Benderitter M, Am J Pathol 2011 178 640 651 10.1016/j.ajpath.2010.10.003 21281796
21. Increased Number of Mast Cells in the Central Nervous System of Adult Male Mice Following Chronic Subordination Stress. Cirulli F, Pistillo L, de Acetis L, Alleva E, Aloe L, Brain Behav Immun 1998 12 123 133 10.1006/brbi.1998.0505 9646937
22. Neuroimmunoendocrine circuitry of the 'brain-skin connection'. Paus R, Theoharides TC, Arck PC, Trends Immunol 2006 27 32 39 10.1016/j.it.2005.10.002 16269267
23. Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer. Ma Y, Hwang RF, Logsdon CD, Ullrich SE, Cancer Res 2013 2013 2013
24. PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer. Khan MW, Keshavarzian A, Gounaris E, Melson JE, Cheon EC, Blatner NR, Chen ZE, Tsai FN, Lee G, Ryu H, Barrett TA, Bentrem DJ, Beckhove P, Khazaie K, Clin Cancer Res 2013 19 2342 2354 10.1158/1078-0432.CCR-12-2623 23487439
25. On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Stechishin OD, Luchman HA, Ruan Y, Blough MD, Nguyen SA, Kelly JJ, Cairncross JG, Weiss S, Neuro-Oncol 2013 15 198 207 10.1093/neuonc/nos302
26. Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner. Hu Y, Chen H, Duan C, Liu D, Qian L, Yang Z, Guo L, Song L, Yu M, Hu M, Shi M, Guo N, Oncogenesis 2013 2 52 10.1038/oncsis.2013.18 23774064
27. Inhibition of VEGF expression through blockade of Hif1[alpha] and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells. Carbajo-Pescador S, Ordoñez R, Benet M, Jover R, García-Palomo A, Mauriz JL, González-Gallego J, Br J Cancer 2013 109 83 91 10.1038/bjc.2013.285 23756865
28. The role of mast cells in allergic inflammation. Amin K, Respir Med 2012 106 9 14 10.1016/j.rmed.2011.09.007 22112783
29. Hyperexpression of FceRI and Toll-like receptor 4 in the intestinal mast cells of Crohn's disease patients. Kobayashi R, Okamura S, Ohno T, Saito H, Mori M, Ra C, Okayama Y, Clin Immunol 2007 125 149 158 10.1016/j.clim.2007.07.008 17827066
30. Radiation-induced mast cell mediators differentially modulate chemokine release from dermal fibroblasts. Müller K, Meineke V, J Dermatol Sci. 2011 61 199 205 10.1016/j.jdermsci.2011.01.003 21292447