High rates of potentially infectious tuberculosis and multidrug-resistant tuberculosis (MDR-TB) among hospital inpatients in KwaZulu Natal, South Africa indicate risk of nosocomial transmission

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Bantubani, Nonkqubela ^a   Kabera, Gaetan ^a   Connolly, Catherine ^a   Rustomjee, Roxana ^a   Reddy, Tarylee ^a   Cohen, Ted ^b   Pym, Alexander S ^a,c  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CAPREOMYCIN; ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; KANAMYCIN; OFLOXACIN; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT;

ADULT; ARTICLE; BACTERIAL TRANSMISSION; BACTERIUM CULTURE; COUGHING; DRUG SENSITIVITY; FEMALE; FLUORESCENCE MICROSCOPY; HOSPITAL ADMISSION; HOSPITAL INFECTION; HOSPITAL PATIENT; HUMAN; INFECTION CONTROL; LIQUID CULTURE; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PUBLIC HOSPITAL; RISK FACTOR; SOUTH AFRICA; TUBERCULOSIS; CLINICAL TRIAL; CROSS INFECTION; EPIDEMIC; EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MIDDLE AGED; MULTICENTER STUDY; TUBERCULOSIS, MULTIDRUG-RESISTANT;

ADULT; ANTITUBERCULAR AGENTS; CROSS INFECTION; DISEASE OUTBREAKS; EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS; FEMALE; HUMANS; INPATIENTS; MALE; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; SOUTH AFRICA; TUBERCULOSIS; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84898745694     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090868     Document Type: Article

References (24)

1. Bradshaw D, Groenewald P, Laubscher R, Nannan N, Nojilana B, et al. (2003) Initial burden of disease estimates for South Africa, 2000. S Afr Med J 93: 682-688. (Pubitemid 37368850)
2. Joint United Nations Programme on HIV/AIDS (UNAIDS) (2013) Global Report: UNAIDS report on the global AIDS epidemic 2013. UNAIDS/JC2502/1/E.
3. World Health Organisation (2013) Global Tuberculosis Report 2013. World Health Organisation, Geneva, Switzerland.
4. Weyer K, Brand J, Lancaster J, Levin J, van der Walt M (2007) Determinants of multidrug-resistant tuberculosis in South Africa: results from a national survey. S Afr Med J 97: 1120-1128. (Pubitemid 350285957)
5. World Health Organisation (2010) Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response. World Health Organisation: Geneva, Switzerland.
6. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, et al. (2006) Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368: 1575-1580. (Pubitemid 44780738)
7. Basu S, Friedland GH, Medlock J, Andrews JR, Shah NS, et al. (2009) Averting epidemics of extensively drug-resistant tuberculosis. Proc Natl Acad Sci U S A 106: 7672-7677.
8. Basu S, Andrews JR, Poolman EM, Gandhi NR, Shah NS, et al. (2007) Prevention of nosocomial transmission of extensively drug-resistant tuberculosis in rural South African district hospitals: an epidemiological modelling study. Lancet 370: 1500-1507. (Pubitemid 47628865)
9. Alvarez GG, Thembela BL, Muller FJ, Clinch J, Singhal N, et al. (2004) Tuberculosis at Edendale Hospital in Pietermaritzburg, Kwazulu Natal, South Africa. Int J Tuberc Lung Dis 8: 1472-1478. (Pubitemid 40070254)
10. Cohen T, Murray M, Wallengren K, Alvarez GG, Samuel EY, et al. (2010) The prevalence and drug sensitivity of tuberculosis among patients dying in hospital in KwaZulu-Natal, South Africa: a postmortem study. PLoS Med 7: e1000296.
11. National Department of Health Republic of South Africa (2012) Antenatal Survey 2011: The National Antenatal Sentinel HIV and Syphilis Prevalence Survey, South Africa, 2011 Available: http://wwwdohgovza
12. Africa NDoHS (2009) National Tuberculosis Management Guidelines.
13. Gullans C (1992) Digestion-Decontamination procedures, Mycobacteriology. In: Isenberg HD, editor Clinical Microbiology Procedures Handbook: American Society for Microbiology: 3.4.4-3.4.7.
14. Stroud LA, Tokars JI, Grieco MH, Crawford JT, Culver DH, et al. (1995) Evaluation of infection control measures in preventing the nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis in a New York City hospital. Infect Control Hosp Epidemiol 16: 141-147.
15. Sacks LV, Pendle S, Orlovic D, Blumberg L, Constantinou C (1999) A comparison of outbreak- and nonoutbreak-related multidrug-resistant tuberculosis among human immunodeficiency virus-infected patients in a South African hospital. Clin Infect Dis 29: 96-101. (Pubitemid 29336809)
16. Rullan JV, Herrera D, Cano R, Moreno V, Godoy P, et al. (1996) Nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis in Spain. Emerg Infect Dis 2: 125-129. (Pubitemid 126444976)
17. Breathnach AS, de Ruiter A, Holdsworth GM, Bateman NT, O'Sullivan DG, et al. (1998) An outbreak of multi-drug-resistant tuberculosis in a London teaching hospital. J Hosp Infect 39: 111-117. (Pubitemid 28291227)
18. O'Donnell MR, Jarand J, Loveday M, Padayatchi N, Zelnick J, et al. (2010) High incidence of hospital admissions with multidrug-resistant and extensively drug-resistant tuberculosis among South African health care workers. Ann Intern Med 153: 516-522.
19. Fennelly KP, Jones-Lopez EC, Ayakaka I, Kim S, Menyha H, et al. (2012) Variability of infectious aerosols produced during coughing by patients with pulmonary tuberculosis. Am J Respir Crit Care Med 186: 450-457.
20. Jones-Lopez EC, Namugga O, Mumbowa F, Ssebidandi M, Mbabazi O, et al. (2013) Cough aerosols of Mycobacterium tuberculosis predict new infection: a household contact study. Am J Respir Crit Care Med 187: 1007-1015.
21. Rouillon A, Perdrizet S, Parrot R (1976) Transmission of tubercle bacilli: The effects of chemotherapy. Tubercle 57: 275-299.
22. Menzies D (1997) Effect of treatment on contagiousness of patients with active pulmonary tuberculosis. Infect Control Hosp Epidemiol 18: 582-586.
23. World Health Organisation (2009) WHO policy on TB infection control in health-care facilities, congregate settings and households. World Health Organisation, Geneva, Switzerland.
24. Shaw JB, Wynn-Williams N (1954) Infectivity of pulmonary tuberculosis in relation to sputum status. Am Rev Tuberc 69: 724-732.