High free fatty acid level is associated with recurrent stroke in cardioembolic stroke patients

Neurology

Volumn 82, Issue 13, 2014, Pages 1142-1148

  Choi, Jeong Yoon ^a   Kim, Ji Sun ^a   Kim, Ji Hyun ^a   Oh, Kyungmi ^a   Koh, Seong Beom ^a   Seo, Woo Keun ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BRAIN ISCHEMIA; CARDIOEMBOLIC STROKE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; FATTY ACID BLOOD LEVEL; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RECURRENT DISEASE; RETROSPECTIVE STUDY; RISK FACTOR; STROKE PATIENT;

AGED; BIOLOGICAL MARKERS; EMBOLISM; FATTY ACIDS, NONESTERIFIED; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECURRENCE; REGISTRIES; STROKE;

EID: 84898737175     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000000264     Document Type: Article

References (31)

1. Ebbert JO, Jensen MD. Fat depots, free fatty acids, and dyslipidemia. Nutrients 2013;5:498-508.
2. Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association scientific statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006;113: 898-918.
3. Fagot-Campagna A, Balkau B, Simon D, et al. High free fatty acid concentration: an independent risk factor for hypertension in the Paris prospective study. Int J Epidemiol 1998;27:808-813.
4. Bays H, Mandarino L, DeFronzo RA. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 2004;89:463-478.
5. Jouven X, Charles MA, Desnos M, Ducimetière P. Circulating nonesterified fatty acid level as a predictive risk factor for sudden death in the population. Circulation 2001;104:756-761.
6. O'Donoghue M, de Lemos JA, Morrow DA, et al. Prognostic utility of heart-type fatty acid binding protein in patients with acute coronary syndromes. Circulation 2006;114:550-557.
7. Cocco G, Chu D. Rimonabant may induce atrial fibrillation. BMJ 2009;338:b1061.
8. Paolisso G, Gualdiero P, Manzella D, et al. Association of fasting plasma free fatty acid concentration and frequency of ventricular premature complexes in nonischemic noninsulin-dependent diabetic patients. Am J Cardiol 1997; 80:932-937.
9. Pilz S, Scharnagl H, Tiran B, et al. Free fatty acids are independently associated with all-cause and cardiovascular mortality in subjects with coronary artery disease. J Clin Endocrinol Metab 2006;91:2542-2547.
10. Pilz S, Scharnagl H, Tiran B, et al. Elevated plasma free fatty acids predict sudden cardiac death: a 6.85-year follow-up of 3315 patients after coronary angiography. Eur Heart J 2007;28:2763-2769.
11. Tansey MJ, Opie LH. Relation between plasma free fatty acids and arrhythmias within the first twelve hours of acute myocardial infarction. Lancet 1983;2:419-422.
12. Khawaja O, Bartz TM, Ix JH, et al. Plasma free fatty acids and risk of atrial fibrillation (from the Cardiovascular Health Study). Am J Cardiol 2012;110:212-216.
13. Seo WK, Kim J, Kim YH, et al. Elevated free fatty acid is associated with cardioembolic stroke subtype. Can J Neurol Sci 2011;38:874-879.
14. Eun MY, Seo WK, Lee J, et al. Age-dependent predictors for recurrent stroke: the paradoxical role of triglycerides. Eur Neurol 2013;69:171-178.
15. Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke 2006;37:577-617.
16. Adams HP Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial: TOAST: Trial of Org 10172 in acute stroke treatment. Stroke 1993;24:35-41.
17. Spence JD. Free fatty acids and stroke from atrial fibrillation. Can J Neurol Sci 2011;38:803.
18. Makiguchi M, Kawaguchi H, Tamura M, Yasuda H. Effect of palmitic acid and fatty acid binding protein on ventricular fibrillation threshold in the perfused rat heart. Cardiovasc Drugs Ther 1991;5:753-761.
19. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet 1994;343: 155-158.
20. Oliver MF. Sudden cardiac death: the lost fatty acid hypothesis. QJM 2006;99:701-709.
21. Connor WE, Hoak JC, Warner ED. Massive thrombosis produced by fatty acid infusion. J Clin Invest 1963;42: 860-866.
22. Didisheim P, Mibashan RS. Activation of Hageman factor (Factor Xii) by long-chain saturated fatty acids. Thromb Diath Haemorrh 1963;143:346-353.
23. Richieri GV, Kleinfeld AM. Unbound free fatty acid levels in human serum. J Lipid Res 1995;36:229-240.
24. Hoak JC. Stearic acid, clotting, and thrombosis. Am J Clin Nutr 1994;60:1050S-1053S.
25. Miller M, Stone NJ, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American heart association. Circulation 2011;123:2292-2333.
26. Ip S, Lichtenstein AH, Chung M, Lau J, Balk EM. Systematic review: association of low-density lipoprotein subfractions with cardiovascular outcomes. Ann Intern Med 2009;150:474-484.
27. Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2010;375:181-183.
28. Barth AS, Merk S, Arnoldi E, et al. Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature. Circ Res 2005;96:1022-1029.
29. White CW, Kerber RE, Weiss HR, Marcus ML. The effects of atrial fibrillation on atrial pressure-volume and flow relationships. Circ Res 1982;51:205-215.
30. Thijssen VL, Ausma J, Borgers M. Structural remodelling during chronic atrial fibrillation: act of programmed cell survival. Cardiovasc Res 2001;52:14-24.
31. Pilz S, Marz W. Free fatty acids as a cardiovascular risk factor. Clin Chem Lab Med 2008;46:429-434.