Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children

Clinics

Volumn 69, Issue 4, 2014, Pages 225-233

  Lima, Aldo A M ^a   Anstead, Gregory M ^c   Zhang, Qiong ^b   Figueiredo, Ítalo L ^a   Soares, Alberto M ^a   Mota, Rosa M S ^a   Lima, Noélia L ^a   Guerrant, Richard L ^a,b   Oriá, Reinaldo B ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF VIRGINIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Growth and development; Hormonal biomarkers; Intestinal barrier function; Micronutrients; Stress

Indexed keywords

GLUTAMINE; HORMONE; RETINOL; SOMATOMEDIN C; VITAMIN; ZINC;

ADOLESCENT; ANTHROPOMETRY; ARTICLE; BLOOD; BRAZIL; CHILD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFECT; FEMALE; GROWTH, DEVELOPMENT AND AGING; HUMAN; INFANT; INTESTINE MUCOSA; MALE; MALNUTRITION; PHYSIOLOGICAL STRESS; POVERTY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADOLESCENT; ANTHROPOMETRY; BRAZIL; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; GLUTAMINE; GROWTH AND DEVELOPMENT; HORMONES; HUMANS; INFANT; INSULIN-LIKE GROWTH FACTOR I; INTESTINAL MUCOSA; MALE; MALNUTRITION; POVERTY AREAS; STRESS, PHYSIOLOGICAL; TREATMENT OUTCOME; VITAMIN A; VITAMINS; ZINC;

EID: 84898731477     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.6061/clinics/2014(04)02     Document Type: Article

References (36)

1. Who working group. Use and interpretation of anthropometric indicators of nutritional status. Bull WHO. 1986;64(6):929-41.
2. Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 2008;371(9608):243-60, http://dx.doi.org/ 10.1016/S0140-6736(07)61690-0.
3. Lima NL, Soares AM, Mota RM, Monteiro HS, Guerrant RL, Lima AA. Wasting and intestinal barrier function in children taking alanylglutamine-supplemented enteral formula. J Pediatr Gastroenterol Nutr. 2007;44(3):365-74, http://dx.doi.org/10.1097/MPG.0b013e31802eecdd.
4. Guerrant RL, Oria RB, Moore SR, Oria MO, Lima AA. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr Rev. 2008;66(9):487-505, http://dx.doi.org/10.1111/j.1753-4887. 2008.00082.x.
5. Niehaus MD, Moore SR, Patrick PD, Derr LL, Lorntz B, Lima AA, et al. Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown. Am J Trop Med Hyg. 2002;66(5):590-3.
6. Ng PC, Lee CH, Lam CW, Chan IH, Wong E, Fok TF. Ghrelin in preterm and term newborns: relation to anthropometry, leptin and insulin. Clin Endocrinol. (Oxf). 2005;63(2):217-22, http://dx.doi.org/10.1111/j.1365-2265.2005.02328.x.
7. Ling H, Waterworth DM, Stirnadel HA, Pollin TI, Barter PJ, Kesaniemi YA, et al. Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. Obesity (Silver Spring). 2009;17(4):737-44, http://dx.doi.org/10.1038/oby.2008.625.
8. Donahue SP, Phillips LS. Response of IGF-1 to nutritional support in malnourished hospital patients: a possible indicator of short-term changes in nutritional status. Am J Clin Nutr. 1989;50(5):962-9.
9. Nindl BC, Alemany JA, Kellogg MD, Rood J, Allison SA, Young AJ, et al. Utility of circulating IGF-I as a biomarker for assessing body composition changes in men during periods of high physical activity superimposed upon energy and sleep restriction. J Appl Physiol. 2007;103(1):340-6, http://dx.doi.org/10.1152/japplphysiol.01321.2006.
10. Kilic M, Taskin E, Ustundag B, Aygun AD. The evaluation of serum leptin level and other hormonal parameters in children with severe malnutrition. Clin Biochem. 2004;37(5):382-7, http://dx.doi.org/10. 1016/j.clinbiochem.2003.12.010.
11. Singleton JR, Baker BL, Thorburn A. Dexamethasone inhibits insulin-like growth factor signaling and potentiates myoblast apoptosis. Endocrinology 2000;141(8):2945-50, http://dx.doi.org/10.1210/endo.141.8.7621.
12. Lago R, Gomez R, Lago F, Gomez-Reino J, Gualillo O. Leptin beyond body weight regulation-current concepts concerning its role in immune function and inflammation. Cell Immunol. 2008;252(1-2):139-45, http:// dx.doi.org/10.1016/j.cellimm.2007.09.004.
13. Arsenault JE, Havel PJ, Lopez de RD, Penny ME, Van Loan MD, Brown KH. Longitudinal measures of circulating leptin and ghrelin concentrations are associated with the growth of young Peruvian children but are not affected by zinc supplementation. Am J Clin Nutr. 2007;86(4):1111-9.
14. Ziegler TR, Evans ME, Fernandez-Estivariz C, Jones DP. Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. Annu Rev Nutr. 2003;23:229-61, http://dx.doi.org/10. 1146/annurev.nutr.23.011702.073036.
15. Ladd FV, Ladd AA, Ribeiro AA, Costa SB, Coutinho BP, Feitosa GA, et al. Zinc and glutamine improve brain development in suckling mice subjected to early postnatal malnutrition. Nutrition. 2010;26(6):662-70, http://dx.doi.org/10.1016/j.nut.2009.11.020.
16. Chen MD, Song YM, Lin PY. Zinc may be a mediator of leptin production in humans. Life Sci. 2000;66(22):2143-9, http://dx.doi.org/10. 1016/S0024-3205(00)00541-5.
17. Dijkhuizen MA, Wieringa FT, West CE, Muherdiyantiningsih Muhilal. Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia. Am J Clin Nutr. 2001;73(4):786-91.
18. van der Hulst RR, van Kreel BK, von Meyenfeldt MF, Brummer RJ, Arends JW, Deutz NE, et al. Glutamine and the preservation of gut integrity. Lancet. 1993;341(8857):1363-5, http://dx.doi.org/10.1016/ 0140-6736(93)90939-E.
19. Bidlingmeyer BA, Cohen SA, Tarvin TL. Rapid analysis of amino acids using pre-column derivatization. J Chromatogr. 1984;336(1):93-104.
20. Oria RB, Patrick PD, Oria MO, Lorntz B, Thompson MR, Azevedo OG, et al. ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children. Braz J Med Biol Res. 2010;43(3):249-56.
21. Guerrant RL, Oria R, Bushen OY, Patrick PD, Houpt E, Lima AA. Global impact of diarrheal diseases that are sampled by travelers: the rest of the hippopotamus. Clin Infect Dis. 2005;41 Suppl 8:S524-30, http://dx.doi. org/10.1086/432946.
22. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269(5223):543-6, http://dx.doi.org/10.1126/science. 7624777.
23. Gura T. Obesity research. Leptin not impressive in clinical trial. Science. 1999;286(5449):881-2.
24. Korner A, Kratzsch J, Gausche R, Schaab M, Erbs S, Kiess W. New predictors of the metabolic syndrome in children-role of adipocytokines. Pediatr Res. 2007;61(6):640-5, http://dx.doi.org/10.1203/01.pdr. 0000262638.48304.ef.
25. Haspolat K, Ece A, Gurkan F, Atamer Y, Tutanc M, Yolbas I. Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition. Clin Biochem. 2007;40(3-4):201-5, http://dx. doi.org/10.1016/j.clinbiochem.2006.11.008.
26. Gilardini L, McTernan PG, Girola A, da Silva NF, Alberti L, Kumar S, et al. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis. 2006;189(2):401-7, http://dx. doi.org/10.1016/j.atherosclerosis.2005.12.021.
27. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, et al. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Am J Physiol. 1997;272(5 pt 1):G943-53.
28. Rhoads JM, Chen W, Gookin J, Wu GY, Fu Q, Blikslager AT, et al. Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism. Gut. 2004;53(4):514-22, http://dx.doi.org/ 10.1136/gut.2003.027540.
29. Kratzsch J, Lammert A, Bottner A, Seidel B, Mueller G, Thiery J, et al. Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence. J Clin Endocrinol Metab. 2002;87 (10):4587-94, http://dx.doi.org/10.1210/jc.2002-020001.
30. Koerner A, Kratzsch J, Kiess W. Adipocytokines: leptin-the classical, resistin-the controversical, adiponectin-the promising, and more to come. Best Pract Res Clin Endocrinol Metab. 2005;19(4):525-46, http:// dx.doi.org/10.1016/j.beem.2005.07.008.
31. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvationinduced immunosuppression. Nature. 1998;394(6696):897-901.
32. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood. 2000;96(5):1723-32.
33. Buyukgebiz B, Ozturk Y, Yilmaz S, Arslan N. Serum leptin concentrations in children with mild protein-energy malnutrition and catch-up growth. Pediatr Int. 2004;46(5):534-8, http://dx.doi.org/10.1111/j.1442-200x.2004.01951.x.
34. Stein K, Vasquez-Garibay E, Kratzsch J, Romero-Velarde E, Jahreis G. Influence of nutritional recovery on the leptin axis in severely malnourished children. J Clin Endocrinol Metab. 2006;91(3):1021-6, http://dx.doi.org/10.1210/jc.2005-1394.
35. Moore SE, Morgan G, Collinson AC, Swain JA, O'Connell MA, Prentice AM. Leptin, malnutrition, and immune response in rural Gambian children. Arch Dis Child. 2002;87(3):192-7, http://dx.doi.org/10.1136/ adc.87.3.192.
36. Spruijt-Metz D, Emken AD, Spruijt MR, Richey JM, Berman LJ, Belcher BR, et al. CRP is related to higher leptin levels in minority peripubertal females regardless of adiposity levels. Obesity. 2012;20(3):512-6, http:// dx.doi.org/10.1038/oby.2011.49.