In vitro induction of tumor necrosis factor-α by ochratoxin A (OTA) from rat liver: Role of Kupffer cells

Mycotoxin Research

Volumn 21, Issue 3, 2005, Pages 172-175

  Al Anati, L ^a   Reinehr, R ^b   Van Rooijen, N ^c   Petzinger, E ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Kupffer cells; Ochratoxin A; TNF

Indexed keywords

EID: 84898728152     PISSN: 01787888     EISSN: 18671632     Source Type: Journal    
DOI: 10.1007/BF02959257     Document Type: Article

References (27)

1. Bakker M, Pieters MN (2002) Risk Assessment of Ochratoxin A in the Netherlands. RIVM report 388802025/2002
2. CAST Council for Agriculture Science and Technology (2003) Mycotoxin: Risk in plant, animal and human systems. Task force report ISSN 0194-4088, No. 139, Ames, Iowa, USA
3. Studer-Rohr I, Schlatter J, Dietrich DR (2000) Kinetic parameter and intraindividual fluctuations of ochratoxin A plasma levels in humans. Arch Toxicol 74:499-510
4. Petzinger E, Ziegler K (2000) Ochratoxin A from a toxicological perspective. J Vet Pharmacol Ther 23:91-98
5. Weidenbach A, Petzinger E (2004) Ochratoxin A: Toxicology of an abundant mycotoxin. Current Topic Pharmacol 8:235-250
6. Fuchs R, Radic B, Peraica M, Hult K, Plestina R (1988) Enterohepatic circulation of ochratoxin A in rats. Period Biol 90:39-42
7. Kontaxi M, Eckhardt U, Hagenbuch B, Stieger B, Meier PJ, Petzinger E (1996) Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J Pharmacol Exp Ther 279:1507-1513
8. Kanisawa M, Suzuki S (1978) Induction of renal and hepatic tumors in mice by ochratoxin A; a mycotoxin. Gann 69:599-600
9. Kuiper-Goodman T, Scott PM (1989) Risk assessment of the mycotoxin ochratoxin A. Biomed Environ Sci 2:179-248
10. Diehl AM (1999) Cytokine regulation of liver regeneration. In: Fleig WE (ed) Normal and Malignant Liver Cell Growth. Kluwer Academic Publisher, Lancaster. 47-55
11. Weidenbach A, Schuh K, Failing K, Petzinger E (2000) Ochratoxin A induced TNF-α release from the isolated and blood-free perfused rat liver. Mycotoxin Research 16(A):189-193
12. Petzinger E, Weidenbach A (2002) Mycotoxins in the food chain: The role of ochratoxins. Livestock Prod Sci 76:245-250
13. Chaisson ML, Brooling JT, Warren L, Tsai S, Fausto N (2002) Hepatocyte-specific inhibittion of NF-kB lead to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest 100:193-202
14. Song Z, Zhou Z, Uriarte S, Wang L, Rang YJ, Chen T, Barve S, McClain CJ (2004) S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatol 40:989-997
15. Ceydeli A, Condon MR, Siegel JH (2003) The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell death. Shock 20:74-84
16. McClain CJ, Song Z, Barve SS, Hill DB, Deaciuc I (2004) Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 287:G497-G502
17. Mitchell SA, Grove J, Spurkland A, Boberg KM, Fleming KA, Day CP, Schrumpf E, Chapman RW (2001) European Study Group of Primary Sclerosing Cholangitis. Association of the tumour necrosis factor alpha-308 but not the interleukin 10-627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis. Gut 49:288-294
18. Al-Anati L, Katz N, Petzinger E (2005) Interference of arachidonic acid and its metabolites with TNF-a release by ochratoxin A from rat liver. Toxicol 208:335-346
19. Van Rooijen N, Sanders A (1994) Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods 174:83-89
20. Eyhorn S, Schlayer HJ, Henninger HP, Dieter P, Hermann R, Woort-Menker M, Becker H, Schaefer HE, Decker K (1988) Rat hepatic sinusoidal endothelial cells in monolayer culture. Biochemical and ultrastructural characteristics. J Hepatol 6:23-35
21. Petzinger E, Müller N, Föllmann W, Deutscher J, Kinne RK (1989) Uptake of bumetanide into isolated rat hepatocytes and primary liver cell cultures. Am J Physiol 256:G78-G86
22. Husztik E, Lazar G, Parducz A (1980) Electron microscopic study of Kupffer-cell phagocytosis blockade induced by gadolinium chloride. Br J Exp Pathol 61:624-630
23. Kim SG, Choi SH (1997) Gadolinium chloride inhibition of rat hepatic microsomal epoxide hydrolase and glutathione S-transferase gene expression. Drug Metab Dispos 25:1416-1423
24. Rai RM, Zhang JX, Clemens MG, Diehl AM (1996) Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and anti-inflammatory cytokines. Shock 6:243-247
25. Van Rooijen N (1989) The liposome-mediated macrophage 'suicide' technique. J Immunol Methods 124:1-6
26. Gekle M, Schwerdt G, Freudinger R, Mildenberger S, Wilflingseder D, Pollack V, Dander M, Schramek H (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J Pharmacol Exp Ther 293:837-844
27. Alvarez L., Gil AG, Ezpeleta O, Garcia-Jalon JA, Lopez De Cerain A. (2004) Immunotoxic effects of ochratoxin A in Wistar rats after oral administration. Food Chem Toxicol 42:825-834