Identifying genetic relatives without compromising privacy

Genome Research

Volumn 24, Issue 4, 2014, Pages 664-672

  He, Dan ^a   Furlotte, Nicholas A ^a   Hormozdiari, Farhad ^a   Joo, Jong Wha J ^b   Wadia, Akshay ^a   Ostrovsky, Rafail ^a   Sahai, Amit ^a   Eskin, Eleazar ^a,c  

^a Engineering IV   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHILD PARENT RELATION; CONTROLLED STUDY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ALGORITHM; GENETIC DATABASE; GENETIC IDENTIFICATION; GENETIC INFORMATION; GENETIC PRIVACY; GENOME SKETCH; HAPLOTYPE MAP; HUMAN; HUMAN EXPERIMENT; HUMAN GENOME; MEDICAL INFORMATION; MOLECULAR PHYLOGENY; NORMAL HUMAN; PEDIGREE; PRIORITY JOURNAL; RELATIVE; SIMULATION; FAMILY; GENETICS; GENOMICS; HUMAN GENOME PROJECT;

FAMILY; GENETIC PRIVACY; GENETIC RESEARCH; GENOME, HUMAN; GENOMICS; HAPMAP PROJECT; HUMAN GENOME PROJECT; HUMANS;

EID: 84898713797     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.153346.112     Document Type: Article

References (34)

1. The 1000 Genomes Project Consortium. 2010. A map of human genome variation from population-scale sequencing. Nature 467: 1061-1073.
2. Browning BL, Browning SR. 2009. A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am J Hum Genet 84: 210-223.
3. DNA databases shut after identities compromised. [Editorial] 2008. Nature 455: 13.
4. Dodis Y, Ostrovsky R, Reyzin L, Smith A. 2008. Fuzzy extractors: how to generate strong keys from biometrics and other noisy data. SIAM J Comput 38: 97-139.
5. Genetic privacy.[Editorial] 2013. Nature 493: 451.
6. Genetics and Public Policy Center. 2011. Alphabetized genetic testing companies. http://www.dnapolicy.org/resources/Alphabetized DTCGeneticTestingCompanies.pdf.
7. Gunderson K, Steemers F, Lee G, Mendoza L, Chee M. 2005. A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet 37: 549-554. (Pubitemid 40617286)
8. Gymrek M, McGuire AL, Golan D, Halperin E, Erlich Y. 2013. Identifying personal genomes by surname inference. Science 339: 321-324.
9. Hardy J, Singleton A. 2009. Genomewide association studies and human disease. N Engl J Med 360: 1759-1768.
10. Heeney C, Hawkins N, De Vries J, Boddington P, Kaye J. 2011. Assessing the privacy risks of data sharing in genomics. Public HealthGenomics 14: 17-25.
11. Hindorff L, Sethupathy P, Junkins H, Ramos E, Mehta J, Collins F, Manolio T. 2009. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci 106: 9362.
12. Homer N, Szelinger S, Redman M,Duggan D, TembeW,Muehling J, Pearson J, Stephan D, Nelson S, Craig D. 2008. Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays. PLoS Genet 4: e1000167.
13. HuffmanW, Pless V. 2003. Fundamentals of error-correcting codes. Cambridge University Press, Cambridge.
14. The International HapMap 3 Consortium. 2010. Integrating common and rare genetic variation in diverse human populations. Nature 467: 52-58.
15. Ishai Y, Kushilevitz E, Ostrovsky R, Prabhakaran M, Sahai A. 2011. Efficient non-interactive secure computation. In Advances in cryptology EUROCRYPT 2011, Vol. 6632 of Lecture notes in computer science (ed. K Paterson), pp. 406-425. Springer, Berlin.
16. Jacobs K, Yeager M, Wacholder S, Craig D, Kraft P, Hunter D, Paschal J, Manolio T, Tucker M, Hoover R, et al. 2009. A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies. Nat Genet 41: 1253-1257.
17. Kahn S. 2011. On the future of genomic data. Science 331: 728-729.
18. Knoppers B, Harris J, Tassé A, Budin-Ljøsne I, Kaye J, Deschênes M, Man H. 2011. Towards a data sharing code of conduct for international genomic research. Genome Med 3: 46.
19. Kyriazopoulou-Panagiotopoulou S, Kashef Haghighi D, Aerni SJ, Sundquist A, Bercovici S, Batzoglou S. 2011. Reconstruction of genealogical relationshipswith applications to Phase III of HapMap. Bioinformatics 27: i333-i341.
20. Liu H, Prugnolle F, Manica A, Balloux F. 2006. A geographically explicit genetic model of worldwide human-settlement history. Am J Hum Genet 79: 230-237. (Pubitemid 44141822)
21. Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WMM. 2010. Robust relationship inference in genome-wide association studies. Bioinformatics 26: 2867-2873.
22. Manolio T, Brooks L, Collins F. 2008. A HapMap harvest of insights into the genetics of common disease. J Clin Invest 118: 1590.
23. Matsuzaki H, Dong S, Loi H, Di X, Liu G, Hubbell E, Law J, Berntsen T, Chadha M, Hui H, et al. 2004. Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat Methods 1: 109-111.
24. McGuire A. 2008. Identifiability of DNA data: the need for consistent federal policy. Am J Bioeth 8: 75-76.
25. NIST. 2008. FIPS, PUB 180-3: Secure hash signature standard. http://csrc. nist.gov/publications/fips/fips180-3/fips180-3-final.pdf.
26. Pemberton TJ,Wang C, Li JZ, Rosenberg NA. 2010. Inference of unexpected genetic relatedness among individuals in HapMap Phase III. Am J Hum Genet 87: 457-464.
27. Reich D, Thangaraj K, Patterson N, Price AL, Singh L. 2009. Reconstructing Indian population history. Nature 461: 489-494.
28. Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273: 1516.
29. Royal CD, Novembre J, Fullerton SM, Goldstein DB, Long JC, Bamshad MJ, Clark AG. 2010. Inferring genetic ancestry: opportunities, challenges, and implications. Am J Hum Genet 86: 661-673.
30. Sankararaman S, Obozinski G, Jordan M, Halperin E. 2009. Genomic privacy and limits of individual detection in a pool. Nat Genet 41: 965- 967.
31. Stankovich J, Bahlo M, Rubio JP, Wilkinson CR, Thomson R, Banks A, Ring M, Foote SJ, Speed TP. 2005. Identifying nineteenth century genealogical links from genotypes. Hum Genet 117: 188-199. (Pubitemid 43136794)
32. Tishkoff SA, Reed FA, Friedlaender FR, Ehret C, Ranciaro A, Froment A,Hirbo JB, Awomoyi AA, Bodo JMM, Doumbo O, et al. 2009. The genetic structure and history of Africans and African Americans. Science 324:1035-1044.
33. Wang J. 2011. Genome-sequencing anniversary. Personal genomes: for one and for all. Science 331: 690.
34. Wheeler DA, Srinivasan M, Egholm M, Shen Y, Chen L, McGuire A, He W, Chen YJJ, Makhijani V, Roth GT, et al. 2008. The complete genome of an individual by massively parallel DNA sequencing. Nature 452: 872-876. (Pubitemid 351550870)