Benzylidine pregnenolones and their oximes as potential anticancer agents: Synthesis and biological evaluation

Steroids

Volumn 84, Issue , 2014, Pages 64-69

  Banday, Abid H ^a,b   Akram, S M M ^a,c   Shameem, Shameem A ^a  

^a Islamia College of Science and Commerce   (India)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF KASHMIR   (India)

Author keywords

Aldol condensation; Benzylidine pregnenolone; Cytoxicity; Dehydration; Nucleophillic addition

Indexed keywords

1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3 HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17 YL) 3 (4 CHLOROPHENYL) PROP 2 EN 1 IMINE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3 HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17 YL) 3 4 NITROPHENYLPROP 2 EN 1 ONE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3 HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHRENE 17 YL) 3 (2 METHOXYPHENYL)PROP 2 EN 1 IMINE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3 HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHRENE 17 YL) 3 (4 FLUOROPHENYL) PROP 2 EN 1 IMINE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3 HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHRENE 17 YL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA) HYDROXY 10,13 DIMETHYL 1 H CYCLOPENTA[ALPHA]PHENANTHREN 17(BETA) YL) 3 O TOLYLPROP 2 EN 1 ONE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA) HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17(BETA) YL) 3 (2 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA) HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17(BETA) YL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA) HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17(BETA) YL) 3 3 TOLYLPROP 2 EN 1 ONE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA) HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHRENE 17(BETA) YL) 3 4 TOLYLPROP 2 EN 1 ONE; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA)HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17(BETA) YL) 3 PHENYLPROP 2 EN 1 ON1E; 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-3-HYDROXY-10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHRENE 17 YL) 3 (3 FLUOROPHENYL) PROP 2 EN 1 ONE; 3 (3 FLUOROPHENYL) 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA) HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17(BETA) YL) PROP 2 EN 1 ONE; 3 (4 FLUOROPHENYL) 1 2,3,4,7,8,9,10,11,12,13,14,15,16,17 TETRADECAHYDRO 3(BETA) HYDROXY 10,13 DIMETHYL 1H CYCLOPENTA[ALPHA]PHENANTHREN 17(BETA) YL) PROP EN 1 ONE; ANTINEOPLASTIC AGENT; BENZYLIDINE PREGNENOLONE; OXIME DERIVATIVE; PREGNENOLONE DERIVATIVE; UNCLASSIFIED DRUG; OXIME; PREGNENOLONE;

ALDOL REACTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; INFRARED SPECTROPHOTOMETRY; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; OXIMES; PREGNENOLONE; PROTON MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED;

EID: 84898667092     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2014.03.010     Document Type: Article

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