Design, characterization and ex vivo evaluation of chitosan film integrating of insulin nanoparticles composed of thiolated chitosan derivative for buccal delivery of insulin

Drug Development and Industrial Pharmacy

Volumn 40, Issue 5, 2014, Pages 691-698

  Mortazavian, Elaheh ^a   Dorkoosh, Farid Abedin ^a   Rafiee Tehrani, Morteza ^a,b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Buccal bilayered film; Buccal delivery; Central composite design; Insulin; Thiolated chitosan

Indexed keywords

CHITOSAN; CHITOSAN BUCCAL FILM; GLYCEROL; INSULIN; INSULIN NANOPARTICLE; NANOPARTICLE; PHOSPHATE BUFFERED SALINE; PLASTICIZER; POLYMER; THIOLATED DIMETHYL ETHYL CHITOSAN; UNCLASSIFIED DRUG; DIMETHYLETHYLCHITOSAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOADHESION FORCE; CENTRAL COMPOSITE DESIGN; CHEEK MUCOSA; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; EX VIVO STUDY; FOLDING ENDURANCE; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RESPONSE SURFACE METHOD; SUSTAINED DRUG RELEASE; SWELLING INDEX; TENSILE STRENGTH; ZETA POTENTIAL; ADHESION; ANALOGS AND DERIVATIVES; ANIMAL; BUCCAL DRUG ADMINISTRATION; CHEMISTRY; GASTROINTESTINAL ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; MOUTH MUCOSA; RABBIT; SURFACE PROPERTY;

ADHESIVENESS; ADMINISTRATION, BUCCAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG DELIVERY SYSTEMS; HYDROGEN-ION CONCENTRATION; INSULIN; MOUTH MUCOSA; NANOPARTICLES; ORAL MUCOSAL ABSORPTION; RABBITS; SURFACE PROPERTIES; TENSILE STRENGTH;

EID: 84898664552     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2014.886590     Document Type: Article

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