EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Takeuchi, Kimio ^a,c   Yanai, Ryoji ^a   Kumase, Fumiaki ^a,b   Morizane, Yuki ^a,b   Suzuki, Jun ^a   Kayama, Maki ^a   Brodowska, Katarzyna ^a   Nakazawa, Mitsuru ^c   Miller, Joan W ^a   Connor, Kip M ^a   Vavvas, Demetrios G ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b OKAYAMA UNIVERSITY   (Japan)

^c HIROSAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; EPIDERMAL GROWTH FACTOR LIKE DOMAIN 7; MICRORNA; MICRORNA 126; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROPILIN 1; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; EGFL7 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANGIOGENESIS ASSAY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; EX VIVO STUDY; EXTRACTION; EYE; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VASCULAR TUBE FORMATION; WESTERN BLOTTING; ANIMAL; BIOASSAY; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; GENE SILENCING; IN VITRO STUDY; METABOLISM; PHOSPHORYLATION;

ANIMALS; BIOLOGICAL ASSAY; ENDOTHELIAL CELLS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE KNOCKDOWN TECHNIQUES; IN VITRO TECHNIQUES; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; NEUROPILIN-1; PHOSPHORYLATION; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84898662027     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091849     Document Type: Article

References (33)

1. Otrock ZK, Mahfouz RA, Makarem JA, Shamseddine AI (2007) Understanding the biology of angiogenesis: review of the most important molecular mechanisms. Blood Cells Mol Dis 39: 212-220. (Pubitemid 47126926)
2. Risau W (1997) Mechanisms of angiogenesis. Nature 386: 671-674.
3. Folkman J, Shing Y (1992) Angiogenesis. The Journal of biological chemistry 267: 10931-10934.
4. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407: 249-257.
5. Miller JW, Le Couter J, Strauss EC, Ferrara N (2013) Vascular endothelial growth factor a in intraocular vascular disease. Ophthalmology 120: 106-114.
6. Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, et al. (1994) Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 118: 445-450. (Pubitemid 24307211)
7. Miller JW, Adamis AP, Shima DT, D'Amore PA, Moulton RS, et al. (1994) Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol 145: 574-584. (Pubitemid 24285965)
8. Alon T, Hemo I, Itin A, Pe'er J, Stone J, et al. (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1: 1024-1028.
9. Carmeliet P (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med 6: 389-395.
10. Folkman J, D'Amore PA (1996) Blood vessel formation: what is its molecular basis? Cell 87: 1153-1155. (Pubitemid 27010098)
11. Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9: 653-660.
12. Folkman J (2003) Fundamental concepts of the angiogenic process. Curr Mol Med 3: 643-651.
13. Papetti M, Herman IM (2002) Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 282: C947-970. (Pubitemid 34663101)
14. Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, et al. (2005) Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev 16: 159-178. (Pubitemid 40616114)
15. Schmidt M, Paes K, De Maziere A, Smyczek T, Yang S, et al. (2007) EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development 134: 2913-2923. (Pubitemid 47386904)
16. Campagnolo L, Leahy A, Chitnis S, Koschnick S, Fitch MJ, et al. (2005) EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am J Pathol 167: 275-284. (Pubitemid 40884788)
17. Fitch MJ, Campagnolo L, Kuhnert F, Stuhlmann H (2004) Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev Dyn 230: 316-324. (Pubitemid 38669592)
18. Parker LH, Schmidt M, Jin SW, Gray AM, Beis D, et al. (2004) The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature 428: 754-758. (Pubitemid 38514720)
19. Soncin F, Mattot V, Lionneton F, Spruyt N, Lepretre F, et al. (2003) VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J 22: 5700-5711. (Pubitemid 37408810)
20. Nichol D, Shawber C, Fitch MJ, Bambino K, Sharma A, et al. (2010) Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood 116: 6133-6143.
21. Schmidt MH, Bicker F, Nikolic I, Meister J, Babuke T, et al. (2009) Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol 11: 873-880.
22. Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, et al. (2008) Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 135: 3989-3993.
23. Baker M, Robinson SD, Lechertier T, Barber PR, Tavora B, et al. (2012) Use of the mouse aortic ring assay to study angiogenesis. Nat Protoc 7: 89-104.
24. Nikolic I, Plate KH, Schmidt MH (2010) EGFL7 meets miRNA-126: an angiogenesis alliance. J Angiogenes Res 2: 9.
25. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-745. (Pubitemid 28155313)
26. Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, et al. (2002) Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis. Proc Natl Acad Sci U S A 99: 383-388. (Pubitemid 34060370)
27. Shao Z, Friedlander M, Hurst CG, Cui Z, Pei DT, et al. (2013) Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One 8: e69552.
28. Nikolic I, Dudvarski Stankovic N, Bicker F, Meister J, Braun H, et al. (2013) EGFL7 ligates alphavbeta3 integrin to enhance vessel formation. Blood.
29. Davis GE (2010) Vascular balancing act: EGFL7 and Notch. Blood 116: 5791-5793.
30. Durrans A, Stuhlmann H (2010) A role for Egfl7 during endothelial organization in the embryoid body model system. J Angiogenes Res 2: 4.
31. Teague EM, Print CG, Hull ML (2010) The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update 16: 142-165.
32. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, et al. (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15: 272-284.
33. Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, et al. (2008) The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 15: 261-271.