Bacillus thuringiensis Cry4Aa insecticidal protein: Functional importance of the intrinsic stability of the unique α4-α5 loop comprising the Pro-rich sequence

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1844, Issue 6, 2014, Pages 1111-1118

  Imtong, Chompounoot ^a   Kanchanawarin, Chalermpol ^c   Katzenmeier, Gerd ^a   Angsuthanasombat, Chanan ^a,b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b Laboratory of Molecular Biophysics and Structural Biochemistry Biophysics Institute for Research and Development (BIRD)   (Thailand)

^c KASETSART UNIVERSITY   (Thailand)

Author keywords

Insecticidal protein; Larval toxicity; Loop rigidity; MD simulations; Pro rich sequence; Site specific mutagenesis

Indexed keywords

CRY4AA PROTEIN; ENDOTOXIN; PROLINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS THURINGIENSIS; DNA SEQUENCE; ESCHERICHIA COLI; HYDROPHOBICITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SOLUBILITY; WILD TYPE;

INSECTICIDAL PROTEIN; LARVAL TOXICITY; LOOP RIGIDITY; MD SIMULATIONS; PRO-RICH SEQUENCE; SITE-SPECIFIC MUTAGENESIS;

AEDES; AMINO ACID SEQUENCE; ANIMALS; BACILLUS THURINGIENSIS; BACTERIAL PROTEINS; ENDOTOXINS; ESCHERICHIA COLI; HEMOLYSIN PROTEINS; LARVA; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PROLINE; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898655700     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2014.03.003     Document Type: Article

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