N-myc downstream regulated gene 1 acts as a tumor suppressor in ovarian cancer

Oncology Reports

Volumn 31, Issue 5, 2014, Pages 2279-2285

  Wang, Bei ^a,b   Li, Jianli ^b   Ye, Zhanying ^b   Li, Zhe ^b   Wu, Xiaohua ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI GENERAL HOSPITAL   (China)

Author keywords

Apoptosis; Invasion; N myc downstream regulated gene 1; Ovarian cancer; Proliferation; Short hairpin RNA

Indexed keywords

PROTEIN P21; PROTEIN P53; SHORT HAIRPIN RNA; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; N-MYC DOWNSTREAM-REGULATED GENE 1 PROTEIN; SIGNAL PEPTIDE; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; COLONY FORMATION; CONTROLLED STUDY; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; N MYC DOWNSTREAM REGULATED GENE 1; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL ADHESION; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; MALE; NUDE MOUSE; OVARY TUMOR; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR INVASION; XENOGRAFT;

ANIMALS; APOPTOSIS; CELL ADHESION; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84898626633     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3072     Document Type: Article

References (32)

1. American Cancer Society: Cancer Facts and Figures. Atlanta, GA: American Cancer Society, 2009. http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2009/index
2. Mandi? A, Teši? M, Vujkov T, Novta N and Rajovi? J: Ovarian cancer stage III/IV: Poor prognostic factors. Arch Oncol 9: 13-16, 2001
3. Li Z, Zhao X, Yang J and Wei Y: Proteomics profile changes in cisplatin-treated human ovarian cancer cell strain. Sci China C Life Sci 48: 648-657, 2005
4. De Marco C, Rinaldo N, Bruni P, et al: Multiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian carcinoma. PLoS One 8: E55362, 2013
5. Okuda T and Kondoh H: Identification of new genes Ndr2 and Ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun 266: 208-215, 1999
6. Zhou D, Salnikow K and Costa M: Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res 58: 2182-2189, 1998
7. Angst E, Dawson DW, Stroka D, et al: N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery 149: 614-624, 2011
8. Maruyama Y, Ono M, Kawahara A, et al: Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis. Cancer Res 66: 6233-6242, 2006
9. Bandyopadhyay S, Pai SK, Hirota S, et al: Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Oncogene 23: 5675-5681, 2004
10. Bandyopadhyay S, Pai SK, Gross SC, et al: The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res 63: 1731-1736, 2003
11. Kovacevic Z, Sivagurunathan S, Mangs H, Chikhani S, Zhang D and Richardson DR: The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms. Carcinogenesis 32: 732-740, 2011
12. Liu W, IIIzumi-Gairani M, Okuda H, et al: KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NF?B complex in human prostate cancer. J Biol Chem 286: 18949-18959, 2011
13. Hosoi F, Izumi H, Kawahara A, et al: N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of ?B kinase ? expression. Cancer Res 69: 4983-4991, 2009
14. Zhao G, Chen J, Deng Y, et al: Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cells. Biochem Biophys Res Commun 408: 154-159, 2011
15. Li Q and Chen H: Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620. Clin Exp Metastasis 28: 127-135, 2011
16. Jiang K, Shen Z, Ye Y, Yang X and Wang S: A novel molecular marker for early detection and evaluating prognosis of gastric cancer: N-myc downstream regulated gene-1 (NDRG1). Scand J Gastroenterol 45: 898-908, 2010
17. Yan X, Chua MS, Sun H and So S: N-Myc down-regulated gene 1 mediates proliferation, invasion, and apoptosis of hepatocellular carcinoma cells. Cancer Lett 262: 133-142, 2008
18. Cheng J, Xie HY, Xu X, et al: NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma. Cancer Lett 310: 35-45, 2011
19. Zou H, Wang D, Gan X, et al: Low TWEAK expression is correlated to the progression of squamous cervical carcinoma. Gynecol Oncol 123: 123-128, 2011
20. Chen S, Han YH, Zheng Y, et al: NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells. Leuk Res 33: 1108-1113, 2009
21. Kalaydjieva L, Gresham D, Gooding R, et al: N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am J Hum Genet 67: 47-58, 2000
22. Kovacevic Z and Richardson DR: The metastasis suppressor, Ndrg-1: A new ally in the fight against cancer. Carcinogenesis 27: 2355-2366, 2006
23. Lv XH, Chen JW, Zhao G, et al: N-myc downstream-regulated gene 1/Cap43 may function as tumor suppressor in endometrial cancer. J Cancer Res Clin Oncol 138: 1703-1715, 2012
24. Wang J, Cai J, Li Z, et al: Expression and biological function of N-myc down-regulated gene 1 in human cervical cancer. J Huazhong Univ Sci Technolog Med Sci 30: 771-776, 2010
25. Liu YL, Bai WT, Luo W, et al: Downregulation of NDRG1 promotes invasion of human gastric cancer AGS cells through MMP-2. Tumour Biol 32: 99-105, 2011
26. Fotovati A, Abu-Ali S, Kage M, Shirouzu K, Yamana H and Kuwano M: N-myc downstream-regulated gene 1 (NDRG1) a differentiation marker of human breast cancer. Pathol Oncol Res 17: 525-533, 2011
27. Tsui KH, Chang YL, Feng TH, Chang PL and Juang HH: Glycoprotein transmembrane nmb: An androgen-downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells. Prostate 72: 1431-1442, 2012
28. Akiba J, Murakami Y, Noda M, et al: N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phase. Cancer Lett 310: 25-34, 2011
29. Gurova KV, Rokhlin OW, Budanov AV, et al: Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells. Cancer Res 63: 2905-2912, 2003
30. Campomenosi P, Monti P, Aprile A, et al: P53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements. Oncogene 20: 3573-3579, 2001
31. el-Deiry WS, Harper JW, O'Connor PM, et al: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174, 1994
32. Elbendary AA, Cirisano FD, Evans AC Jr., et al: Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells. Clin Cancer Res 2: 1571-1575, 1996