Identification of NDRG1-regulated genes associated with invasive potential in cervical and ovarian cancer cells

Biochemical and Biophysical Research Communications

Volumn 408, Issue 1, 2011, Pages 154-159

  Zhao, Gang ^a,b   Chen, Jiawei ^a   Deng, Yanqiu ^b   Gao, Feng ^a   Zhu, Jiwei ^c   Feng, Zhenzhong ^a   Lv, Xiuhong ^a   Zhao, Zheng ^d  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d SAS INSTITUTE INC   (United States)

Author keywords

Cervical cancer; Invasion; NDRG1; Ovarian cancer

Indexed keywords

COMPLEMENTARY DNA; INTERLEUKIN 6; INTERLEUKIN 8; MATRILYSIN; PROTEIN KINASE FYN;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL ADHESION; CELL INVASION; CELL MEMBRANE POTENTIAL; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SILENCING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; N MYC DOWNSTREAM REGULATED GENE 1; ONCOGENE; OVARY CANCER; PRIORITY JOURNAL; RECEPTOR UPREGULATION; UTERINE CERVIX CANCER;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; UTERINE CERVICAL NEOPLASMS;

EID: 79955405216     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.140     Document Type: Article

References (40)

1. Okuda T., Kondoh H. Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem. Biophys. Res. Commun. 1999, 266:208-215.
2. 2+ compounds. Cancer Res. 1998, 58:2182-2189.
3. Q. Li, H. Chen, Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620, Clin. Exp. Metastasis. (2010) [Epub ahead of print].
4. Jiang K., Shen Z., Ye Y., Yang X., Wang S. A novel molecular marker for early detection and evaluating prognosis of gastric cancer: N-myc downstream regulated gene-1 (NDRG1). Scand. J. Gastroenterol. 2010, 45:898-908.
5. Maruyama Y., Ono M., Kawahara A., Yokoyama T., Basaki Y., Kage M., Aoyagi S., Kinoshita H., Kuwano M. Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis. Cancer Res. 2006, 66:6233-6242.
6. Gerhard R., Nonogaki S., Fregnani J.H., Soares F.A., Nagai M.A. NDRG1 protein overexpression in malignant thyroid neoplasms. Clinics (Sao Paulo) 2010, 65:757-762.
7. Nishio S., Ushijima K., Tsuda N., Takemoto S., Kawano K., Yamaguchi T., Nishida N., Kakuma T., Tsuda H., Kasamatsu T., Sasajima Y., Kage M., Kuwano M., Kamura T. Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma. Cancer Lett. 2008, 264:36-43.
8. Wang Z., Wang F., Wang W.Q., Gao Q., Wei W.L., Yang Y., Wang G.Y. Correlation of N-myc downstream-regulated gene 1 overexpression with progressive growth of colorectal neoplasm. World J. Gastroenterol. 2004, 10:550-554.
9. Pattillo R.A., Hussa R.O., Story M.T., Ruckert A.C., Shalaby M.R., Mattingly R.F. Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line. Science 1977, 196:1456-1458.
10. Shenhua X., Lijuan Q., Hanzhou N., Xinghao N., Chihong Z., Gu Z., Weifang D., Yongliang G. Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization. J. Exp. Clin. Cancer Res. 1999, 18:233-239.
11. Al-Nasiry S., Geusens N., Hanssens M., Luyten C., Pijnenborg R. The use of Alamar Blue assay for quantitative analysis of viability migration and invasion of choriocarcinoma cells. Hum. Reprod. 2007, 22:1304-1309.
12. Martin A., Ochagavia M.E., Rabasa L.C., Miranda J., Fernandez-de-Cossio J., Bringas R. BisoGenet: a new tool for gene network building, visualization and analysis. BMC Bioinformatics 2010, 11:91-99.
13. Monge M., Colas E., Doll A., Gil-Moreno A., Castellvi J., Diaz B., Gonzalez M., Lopez-Lopez R., Xercavins J., Carreras R., Alameda F., Canals F., Gabrielli F., Reventos J., Abal M. Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress. Carcinogenesis 2009, 30:1288-1297.
14. Kaulfuss S., Grzmil M., Hemmerlein B., Thelen P., Schweyer S., Neesen J., Bubendorf L., Glass A.G., Jarry H., Auber B., Burfeind P. Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells. Mol. Endocrinol. 2008, 22:1606-1621.
15. Sansone P., Storci G., Tavolari S., Guarnieri T., Giovannini C., Taffurelli M., Ceccarelli C., Santini D., Paterini P., Marcu K.B., Chieco P., Bonafe M. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J. Clin. Invest. 2007, 117:3988-4002.
16. Emara M., Turner A.R., Allalunis-Turner J. Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues. Cancer Cell Int. 2010, 10:33-48.
17. Boldt H.B., Conover C.A. Overexpression of pregnancy-associated plasma protein-a in ovarian cancer cells promotes tumor growth in vivo. Endocrinology 2011, [Epub ahead of print].
18. Li X., Cowell J.K., Sossey-Alaoui K. CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer. Oncogene 2004, 23:1474-1480.
19. Yadav V., Denning M.F. Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Mol. Carcinog. 2010, [Epub ahead of print].
20. Hao R.T., Zhang X.H., Pan Y.F., Liu H.G., Xiang Y.Q., Wan L., Wu X.L. Prognostic and metastatic value of phosphatase of regenerating liver-3 in invasive breast cancer. J. Cancer Res. Clin. Oncol. 2010, 136:1349-1357.
21. Chua H.H., Yeh T.H., Wang Y.P., Huang Y.T., Sheen T.S., Lo Y.C., Chou Y.C., Tsai C.H. Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma. Head Neck 2008, 30:427-436.
22. Chiang Y.Y., Tsai M.H., Lin T.Y., Chiang I.P. Expression profile of metastasis-related genes in invasive oral cancers. Histol. Histopathol. 2008, 23:1213-1222.
23. Chiu K.H., Chang Y.H., Wu Y.S., Lee S.H., Liao P.C. Quantitative Secretome Analysis Reveals that COL6A1 is a Metastasis-Associated Protein Using Stacking Gel-Aided Purification Combined with iTRAQ Labeling. J. Proteome Res. 2011, [Epub ahead of print].
24. Bandyopadhyay S., Pai S.K., Gross S.C., Hirota S., Hosobe S., Miura K., Saito K., Commes T., Hayashi S., Watabe M., Watabe K. The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 2003, 63:1731-1736.
25. Tu L.C., Yan X., Hood L., Lin B. Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. Mol. Cell Proteomics 2007, 6:575-588.
26. Yeh Y.-C., Sheu B.-S., Cheng H.-C., Wang Y.-L., Yang H.-B., Wu J.-J. Elevated serum matrix metalloproteinase-3 and -7 in H. pylori-related gastric cancer can be biomarkers correlating with a poor survival. Dig. Dis. Sci. 2009, 55:1649-1657.
27. Kim S., Kang H.Y., Nam E.-H., Choi M.-S., Zhao X.-F., Hong C.S., Lee J.W., Lee J.H., Park Y.-K. TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. Carcinogenesis 2010, 31:597-606.
28. Quintanilla-Dieck M.J., Codriansky K., Keady M., Bhawan J., Runger T.M. Cathepsin K in melanoma invasion. J. Invest. Dermatol. 2008, 128:2281-2288.
29. Song Y., Oda Y., Hori M., Kuroiwa K., Ono M., Hosoi F., Basaki Y., Tokunaga S., Kuwano M., Naito S., Tsuneyoshi M. N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin. Hum. Pathol. 2009, 41:214-222.
30. Wang J., Cai J., Li Z., Hu S., Yu L., Xiao L., Wang Z. Expression and biological function of N-myc down-regulated gene 1 in human cervical cancer. J Huazhong Univ Sci Technolog Med. Sci. 2010, 30:771-776.
31. Song J.Y., Lee J.K., Lee N.W., Jung H.H., Kim S.H., Lee K.W. Microarray analysis of normal cervix, Carcinoma in situ, and invasive cervical cancer: identification of candidate genes in pathogenesis of invasion in cervical cancer. Int. J. Gynecol. Cancer 2008, 18:1051-1059.
32. Fan C., Yu J., Liu Y., Xu H., Wang E. Increased NDRG1 Expression is Associated with Advanced T Stages and Poor Vascularization in Non-small Cell Lung Cancer. Pathol. Oncol. Res. 2010, [Epub ahead of print].
33. Strzelczyk B., Szulc A., Rzepko R., Kitowska A., Skokowski J., Szutowicz A., Pawelczyk T. Identification of high-risk stage II colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion. Ann. Surg. Oncol. 2009, 16:1287-1294.
34. Akiba J., Ogasawara S., Kawahara A., Nishida N., Sanada S., Moriya F., Kuwano M., Nakashima O., Yano H. N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma. Oncol. Rep. 2008, 20:1329-1335.
35. Chua M.S., Sun H., Cheung S.T., Mason V., Higgins J., Ross D.T., Fan S.T., So S. Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod. Pathol. 2007, 20:76-83.
36. Ellen T.P., Ke Q., Zhang P., Costa M. NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis 2008, 29:2-8.
37. Sibold S., Roh V., Keogh A., Studer P., Tiffon C., Angst E., Vorburger S.A., Weimann R., Candinas D., Stroka D. Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS. Lett. 2007, 581:989-994.
38. Kovacevic Z., Sivagurunathan S., Mangs H., Chikhani S., Zhang D., Richardson D.R. The metastasis suppressor N-MYC downstream regulated gene 1 (NDRG1), UP-regulates P21 VIA P53-independent mechanisms. Carcinogenesis 2010, [Epub ahead of print].
39. Liu Y.L., Bai W.T., Luo W., Zhang D.X., Yan Y., Xu Z.K., Zhang F.L. Downregulation of NDRG1 promotes invasion of human gastric cancer AGS cells through MMP-2. Tumour Biol. 2010, 32:99-105.
40. Li Q., Chen H. Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620. Clin. Exp. Metastasis 2010, 28:127-135.