Mast cell-derived serine proteinase regulates T helper 2 polarization

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Liu, Zhi Qiang ^a,d   Song, Jiang Ping ^c   Liu, Xiaoyu ^a   Jiang, Jing ^a,d   Chen, Xiao ^c   Yang, Litao ^d   Hu, Tianyong ^d   Zheng, Peng Yuan ^b   Liu, Zhi Gang ^a   Yang, Ping Chang ^a  

^a Shenzhen University School of Medicine   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c FUWAI HOSPITAL   (China)

^d ENT Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GATA3 PROTEIN, MOUSE; INTERLEUKIN 4; PROTEIN BCL 6; SERINE PROTEINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 3;

ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CELL CULTURE; CYTOLOGY; ENZYMOLOGY; FEMALE; GENETICS; IMMUNOLOGY; MALE; MAST CELL; METABOLISM; MOUSE; RNA INTERFERENCE; TH2 CELL;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GATA3 TRANSCRIPTION FACTOR; INTERLEUKIN-4; MALE; MAST CELLS; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-BCL-6; RNA INTERFERENCE; RNA, SMALL INTERFERING; SERINE PROTEASES; TH2 CELLS;

EID: 84898617993     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04649     Document Type: Article

References (27)

1. Galli, S. J., Nakae, S. & Tsai, M. Mast cells in the development of adaptive immune responses. Nat Immunol 6, 135-142 (2005). (Pubitemid 40268194)
2. de Vries, V. C., Elgueta, R., Lee, D. M. & Noelle, R. J. Mast Cell Protease 6 Is Required for Allograft Tolerance. Transplant Proc 42, 2759-2762 (2010).
3. Nakano, T. et al. Immunological and Regenerative Aspects of Hepatic Mast Cells in Liver Allograft Rejection and Tolerance. PLoS One 7, e37202 (2012).
4. Oikonomopoulou, K. et al. Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more. Biol Chem 387, 677-685 (2006). (Pubitemid 43964789)
5. Mari, B. et al. Thrombin and trypsin-induced Ca(21) mobilization in human T cell lines through interaction with different protease-activated receptors. FASEB J 10, 309-316 (1996).
6. Crotty, S., Johnston, R. J. & Schoenberger, S. P. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol 11, 114-120 (2010).
7. Takahashi, H. et al. TGF-[beta] and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol 13, 587-595 (2012).
8. Mantel, P. Y. et al. GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol 5, e329 (2007).
9. Yurugi, H. & Rajalingam, K. A Role for Prohibitin in Mast Cell Activation: Location Matters. Sci. Signal. 6, e29 (2013).
10. Jacob, C. et al. Mast Cell Tryptase Controls Paracellular Permeability of the Intestine. J Biol Chem 280, 31936-31948 (2005).
11. Gao, G., Ouyang, A., Kaufman, M. P. & Yu, S. ERK1/2 signaling pathway in mast cell activation-induced sensitization of esophageal nodose C-fiber neurons. Dis Esophagus 24, 194-203 (2011).
12. Banfi, C. et al. Mitochondrial reactive oxygen species: a common pathway for PAR1-and PAR2-mediated tissue factor induction in human endothelial cells. J Thromb Haemost 7, 206-216 (2009).
13. Suen, J. Y. et al. Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells. PLoS One 5, e13809 (2010).
14. Chen, W. et al. Conversion of Peripheral CD41CD252 Naive T Cells to CD41CD251Regulatory T Cells by TGF-beta Induction of Transcription Factor Foxp3. J Exp Med 198, 1875-1886 (2003). (Pubitemid 38032120)
15. Chen, X. et al. Intestinal epithelial cell-derived integrin alpha v beta 6 plays an important role in the induction of regulatory T cells and inhibits an antigenspecific Th2 response. J Leukoc Biol 90, 751-759 (2011).
16. Kurotaki, D. et al. CSF-1-Dependent Red Pulp Macrophages Regulate CD4 T Cell Responses. J Immunol 186, 2229-2237 (2011).
17. He, S. H. et al. Interferon-lambda Mediates Oral Tolerance and Inhibits Antigen-Specific, T-Helper 2 Cell-Mediated Inflammation in Mouse Intestine. Gastroenterology 141, 249-258 (2011).
18. Yang, X. O. et al. Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs. Immunity 29, 44-56 (2008).
19. Esposito, M. et al. IL-17-and IFN-gamma-secreting Foxp31 T cells infiltrate the target tissue in experimental autoimmunity. J Immunol 185, 7467-7473 (2010).
20. Beyer, M. & Schultze, J. L. Plasticity of Treg cells: Is reprogramming of Treg cells possible in the presence of FOXP3? Int Immunopharmacol 11, 555-560 (2011).
21. Chung, Y. et al. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med 17, 983-988 (2011).
22. Harris, M. B., Mostecki, J. & Rothman, P. B. Repression of an Interleukin-4-responsive Promoter Requires Cooperative BCL-6 Function. J Biol Chem 280, 13114-13121 (2005).
23. Kusam, S., Toney, L. M., Sato, H. & Dent, A. L. Inhibition of Th2 Differentiation and GATA-3 Expression by BCL-6. J Immunol 170, 2435-2441 (2003). (Pubitemid 36245631)
24. Wan, Y. Y. & Flavell, R. A. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunol Rev 212, 114-130 (2006). (Pubitemid 44116704)
25. Hamilton, M. J. et al. Essential role for mast cell tryptase in acute experimental colitis. Proc Natl Acad Sci USA 108, 290-295 (2011).
26. Shin, K. et al. Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection. J Immunol 180, 4885-4891 (2008).
27. Rodewald, H. R. & Feyerabend, T. Widespread Immunological Functions of Mast Cells: Fact or Fiction? Immunity 37, 13-24 (2012).