Expression of angiopoietin-2 and vascular endothelial growth factor receptor-3 correlates with lymphangiogenesis and angiogenesis and affects survival of oral squamous cell carcinoma

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Li, Chao ^a,b   Fan, Jinchuan ^a   Song, Xicheng ^c   Zhang, Bing ^a   Chen, Yu ^b   Li, Chunhua ^a   Mi, Kun ^a   Ma, Hong ^d   Song, Yufeng ^d   Tao, Xiaofeng ^e   Li, Guojun ^f  

^a SICHUAN CANCER HOSPITAL   (China)

^b SICHUAN UNIVERSITY   (China)

^c QINGDAO UNIVERSITY   (China)

^d GUIZHOU MEDICAL UNIVERSITY   (China)

^e SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^f UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; VASCULOTROPIN RECEPTOR 3;

ADULT; ALCOHOL CONSUMPTION; ANGIOGENESIS; ARTICLE; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CAPILLARY DENSITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; MAJOR CLINICAL STUDY; MALE; MOUTH SQUAMOUS CELL CARCINOMA; POSTOPERATIVE PERIOD; PROGNOSIS; PROTEIN EXPRESSION; SMOKING; TONGUE CANCER; TUMOR DIFFERENTIATION; UPREGULATION; DISEASE COURSE; GENE EXPRESSION REGULATION; METABOLISM; MICROVASCULATURE; MIDDLE AGED; MOUTH TUMOR; NEOVASCULARIZATION (PATHOLOGY); PATHOPHYSIOLOGY; SQUAMOUS CELL CARCINOMA; SURVIVAL; VASCULARIZATION;

ANGIOPOIETIN-2; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MALE; MICROVESSELS; MIDDLE AGED; MOUTH NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; SURVIVAL ANALYSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 84898613773     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075388     Document Type: Article

References (20)

1. Massano J, Regateiro FS, Januário G, Ferreira A (2006) Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102: 67-76.
2. Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, et al. (2002) Ang-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by ang-1. Dev Cell 3: 411-423.
3. C Li, HC Feng, YF Song (2005) Expression of Angiopoietin-2 and Vascular Endothelial Growth Factor in Oral Squamous Cell Carcinoma and Its Significance. The Chin-Germ J of Clin oncol 4: 232-237.
4. Saharinen P, Tammela T, Karkkainen MJ, Alitalo K (2004) Lymphaticvascu-lature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 25:387-395.
5. Edge SB, Compton CC (2010)The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471-1474.
6. Bryne M, Koppang HS, Lilleng R, Kjaerheim A (1992)Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol 166:375-381.
7. Ochiumi T, Tanaka S, Oka S, Hiyama T, Ito M, et al. (2004)Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Int J Oncol 24:539-547.
8. Weidner N (1995) Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36:169-180.
9. Nisato RE, Tille JC, Pepper MS (2003) Lymphangiogenesis and tumor metastasis. Thromb Haemost 90:591-597.
10. Dumoff KL, Chu C, Xu X, Pasha T, Zhang PJ, et al. (2005) Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in earlystage squamous cell carcinoma of the uterine cervix. Mod Pathol 18: 97-104.
11. Fogt F, Zimmerman RL, Ross HM, Daly T, Gausas RE (2004) Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 11:47-50.
12. Urabe A, Matsumoto T, Kimura M, Sonoue H, Kinoshita K (2004) Grading system of lymphatic invasion according to D2-40 immunostaining is useful for the prediction of nodal metastasis in squamous cell carcinoma of the uterine cervix. Histopathology 4: 493-497.
13. Urabe A, Matsumoto T, Kimura M, Sonoue H, Kinoshita K (2006) First international consensus on the methodology of lymphangiogenesis quantification in solid human tumors. Br J Cancer 95:1611-1625.
14. He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, et al. (2005) vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 65: 4739-4746.
15. Botting SK, Fouad H, Elwell K, Rampy BA, Salama SA, et al. (2010) Prognostic Significance of VEGFR-3 and Lymphatic Density (LVD) in Invasive Squamous Cell Cervical Cancer. Transl Oncol 3:170-175.
16. Yashiro M, Shinto O, Nakamura K, Tendo M, Matsuoka T, et al. (2009) Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model. Br J Cancer 101:1100-1106.
17. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, et al. (2000) Vascular-specific growth factors and blood vessel formation. Nature 407: 242-248.
18. Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen MI, et al. (2001) Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med 7: 199-205.
19. Wigle JT, Oliver G (1999) Prox1 function is required for the development of the murine lymphatic system. Cell 98: 769-778.
20. Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, et al. (2012) Effects of angiopoietin-2 blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104:461-475.