Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk

Archives of Dermatological Research

Volumn 306, Issue 3, 2014, Pages 231-238

  Debniak T ^a   Soczawa, E ^a   Boer, M ^a   Rozewicka Czabanska M ^a   Wisniewska J ^a   Serrano Fernandez, P ^a   Mirecka, A ^a   Paszkowska Szczur, K ^a   Lubinski, J ^a   Krysztoforska, L ^b   Adamski, Z ^c   Maleszka, R ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

^b Regional Hospital   (Poland)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Psoriasis vulgaris; RPTOR; TRAF3IP2; ZNF750

Indexed keywords

ADULT; ALLELE; ARTICLE; DISEASE SEVERITY; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; JOINT; MAJOR CLINICAL STUDY; MALE; NAIL; PRIORITY JOURNAL; PSORIASIS; RPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TRAF3IP2 GENE; ZNF750 GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGE OF ONSET; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; PSORIASIS; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

EID: 84898610009     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-013-1407-9     Document Type: Article

References (28)

1. Bhalerao J, Bowcock AM (1998) The genetics of psoriasis: a complex disorder of the skin and immune system. Hum Mol Genet 7:1537-1545
2. Birnbaum RY, Hayashi G, Cohen I, Poon A, Chen H, Lam ET et al (2011) Association analysis identifies ZNF750 regulatory variants in psoriasis. BMC Med Genet 12:167
3. Böhm B, Burkhardt H, Uebe S, Apel M, Behrens F, Reis A et al (2012) Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization. Arthritis Res Ther. 14:R84
4. Capon F, Helms C, Veal CD, Tillman D, Burden AD, Barker JN et al (2004) Genetic analysis of PSORS2 markers in a UK dataset supports the association between RAPTOR SNPs and familial psoriasis. J Med Genet 41:459-460
5. Carter KW, McCaskie PA, Palmer LJ (2006) JLIN: a java based linkage disequilibrium plotter. BMC Bioinformatics 7:60
6. Elder JT, Nair RP, Guo SW, Henseler T, Christophers E, Voorhees JJ (1994) The genetics of psoriasis. Arch Dermatol 130:216-224
7. Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV et al (2010) Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet 42:991-995
8. Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Strange A, Capon F et al (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 42: 985-990
9. Gottlieb AB (2005) Psoriasis: emerging therapeutic strategies. Nat Rev Drug Discov 4:19-34
10. Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D et al (2003) A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet 35:349-356
11. Henseler T (1997) The genetics of psoriasis. J Am Acad Dermatol 37:1-11
12. Hunter CA (2007) Act1-ivating IL-17 inflammation. Nat Immunol 8:232-234
13. Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E et al (2010) Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet 42:996-999
14. Hwu WL, Yang CF, Fann CS, Chen CL, Tsai TF, Chien YH et al (2005) Mapping of psoriasis to 17q terminus. J Med Genet 42:152-158
15. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP et al (2012) Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet 90(5):796-808
16. Jordan CT, Cao L, Roberson ED, Pierson KC, Yang CF, Joyce CE et al (2012) PSORS2 is due to mutations in CARD14. Am J Hum Genet 90(5):784-795
17. Julià A, Tortosa R, Hernanz JM, Cañete JD, Fonseca E, Ferrándiz C et al (2012) Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes. Hum Mol Genet 15(21):4549-4557
18. Krueger JG (2002) The immunologic basis for the treatment of psoriasis with new biologic agents. J Am Acad Dermatol 46:1-23
19. Lebwohl M (2003) Psoriasis. Lancet 361:1197-1204
20. Qian Y, Liu C, Hartupee J, Altuntas CZ, Gulen MF, Jane-Wit D et al (2007) The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nature Immun. 8:247-256
21. R Development Core Team (2010) A language and environment for statistical computing. R Foundation for Statistical Computing
22. Schwandner R, Yamaguchi K, Cao Z (2000) Requirement of tumor necrosis factor receptor-associated factor TRAF)6 in interleukin 17 signal transduction. J Exp Med 191:1233-1240
23. Sinnwell JP, Schaid DJ (2012) Statistical analysis of haplotypes with traits and covariates when linkage phase is ambiguous. http://mayoresearch.mayo. edu/mayo/research/schaid
24. Stuart P, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV et al (2006) Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage. J Med Genet 43:12-17
25. Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008) Th17 cells in human disease. Immunol Rev 223:87-113
26. Tomfohrde J, Silverman A, Barnes R, Fernandez-Vina MA, Young M, Lory D et al (1994) Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 264:1141-1145
27. Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Collaborative Association Study of Psoriasis (CASP), Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium 2 et al (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet 44(12):1341-1348
28. Yang CF, Hwu WL, Yang LC, Chung WH, Chien YH, Hung CF et al (2008) A promoter sequence variant of ZNF750 is linked with familial psoriasis. J Investig Dermatol 128:1662-1668