The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth

EMBO Reports

Volumn 15, Issue 2, 2014, Pages 165-174

  Wang, Hongyan ^a,b,f   Li, Song ^a,b   Wang, Cheng ^a   Sandanaraj, Edwin ^c,d   Aw, Sherry S Y ^a   Koe, Chwee T ^a,b   Wong, Jack J L ^b,e   Yu, Fengwei ^a,b,e   Ang, Beng T ^c,d,f   Tang, Carol ^d,f,g,h  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

^d NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^g DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^h INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

asymmetric division; neuroblasts; polarity; the SCF complex

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; PROTEIN KINASE B; SCF SLIMB E3 LIGASE COMPLEX; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DROSOPHILA PROTEIN; PROTEIN SERINE THREONINE KINASE; SAK PROTEIN, DROSOPHILA; SUPERNUMERARY LIMBS PROTEIN, DROSOPHILA; TRANSDUCIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; ASYMMETRIC CELL DIVISION; CELL DIFFERENTIATION; CELL GROWTH; CELL RENEWAL; CONTROLLED STUDY; DROSOPHILA; EMBRYO; ENZYME ACTIVATION; LARVA; NEUROBLAST; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; ANIMAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEURAL STEM CELL; PHYSIOLOGY;

ANIMALS; ASYMMETRIC CELL DIVISION; CELL CYCLE PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; NEURAL STEM CELLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; TRANSDUCIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84898607832     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1002/embr.201337966     Document Type: Article

References (33)

1. Doe CQ, (2008) Neural stem cells: balancing self-renewal with differentiation. Development 135: 1575-1587 (Pubitemid 351895487)
2. Gonzalez C, (2013) Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics. Nat Rev Cancer 13: 172-183
3. Wu PS, Egger B, Brand AH, (2008) Asymmetric stem cell division: lessons from Drosophila. Semin Cell Dev Biol 19: 283-293
4. Chang KC, Wang C, Wang H, (2012) Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells. BioEssays 34: 301-310
5. Bello BC, Izergina N, Caussinus E, Reichert H, (2008) Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development. Neural Develop 3: 5
6. Boone JQ, Doe CQ, (2008) Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells. Dev Neurobiol 68: 1185-1195
7. Bowman SK, Rolland V, Betschinger J, Kinsey KA, Emery G, Knoblich JA, (2008) The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev Cell 14: 535-546
8. Wang C, Li S, Januschke J, Rossi F, Izumi Y, Garcia-Alvarez G, Gwee SSL, Soon SB, Sidhu HK, Yu F, Matsuzaki F, Gonzalez C, Wang H, (2011) An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. Dev Cell 21: 520-533
9. Johnston CA, Hirono K, Prehoda KE, Doe CQ, (2009) Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells. Cell 138: 1150-1163
10. Wang H, Somers GW, Bashirullah A, Heberlein U, Yu F, Chia W, (2006) Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev 20: 3453-3463 (Pubitemid 44969162)
11. Wang H, Ouyang Y, Somers WG, Chia W, Lu B, (2007) Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature 449: 96-100 (Pubitemid 47373766)
12. Lee CY, Andersen RO, Cabernard C, Manning L, Tran KD, Lanskey MJ, Bashirullah A, Doe CQ, (2006) Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev 20: 3464-3474 (Pubitemid 44969163)
13. Lee T, Luo L, (1999) Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22: 451-461 (Pubitemid 29159845)
14. Neumuller RA, Richter C, Fischer A, Novatchkova M, Neumuller KG, Knoblich JA, (2011) Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell 8: 580-593
15. Ho MS, Tsai PI, Chien CT, (2006) F-box proteins: the key to protein degradation. J Biomed Sci 13: 181-191
16. Spana EP, Doe CQ, (1995) The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. Development 121: 3187-3195
17. Broadus J, Doe CQ, (1997) Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts. Curr Biol 7: 827-835 (Pubitemid 27493121)
18. Siller KH, Serr M, Steward R, Hays TS, Doe CQ, (2005) Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control. Mol Biol Cell 16: 5127-5140 (Pubitemid 41566826)
19. Wu JT, Lin HC, Hu YC, Chien CT, (2005) Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation. Nat Cell Biol 7: 1014-1020
20. Rogers GC, Rusan NM, Roberts DM, Peifer M, Rogers SL, (2009) The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J Cell Biol 184: 225-239
21. Cunha-Ferreira I, Rodrigues-Martins A, Bento I, Riparbelli M, Zhang W, Laue E, Callaini G, Glover DM, Bettencourt-Dias M, (2009) The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. Curr Biol 19: 43-49
22. Basto R, Brunk K, Vinadogrova T, Peel N, Franz A, Khodjakov A, Raff JW, (2008) Centrosome amplification can initiate tumorigenesis in flies. Cell 133: 1032-1042 (Pubitemid 351787756)
23. Coffer PJ, Jin J, Woodgett JR, (1998) Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 335 (Pt 1): 1-13 (Pubitemid 28477043)
24. Chell JM, Brand AH, (2010) Nutrition-responsive glia control exit of neural stem cells from quiescence. Cell 143: 1161-1173
25. Sousa-Nunes R, Yee LL, Gould AP, (2011) Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature 471: 508-512
26. Wong JJ, Li S, Lim EK, Wang Y, Wang C, Zhang H, Kirilly D, Wu C, Liou YC, Wang H, Yu F, (2013) A cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol 11: e1001657
27. Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M, (2009) The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev Cell 17: 800-810
28. Madhavan S, Zenklusen JC, Kotliarov Y, Sahni H, Fine HA, Buetow K, (2009) Rembrandt: helping personalized medicine become a reality through integrative translational research. Mol Cancer Res 7: 157-167
29. TCG A, (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455: 1061-1068
30. Frescas D, Pagano M, (2008) Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 8: 438-449 (Pubitemid 351744963)
31. Song Y, Lu B, (2011) Regulation of cell growth by Notch signaling and its differential requirement in normal versus tumor-forming stem cells in Drosophila. Genes Dev 25: 2644-2658
32. Rossi F, Gonzalez C, (2012) Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth. EMBO Rep 13: 157-162
33. Januschke J, Gonzalez C, (2010) The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. J Cell Biol 188: 693-706