Freeze-drying of ovalbumin loaded mesoporous silica nanoparticle vaccine formulation increases antigen stability under ambient conditions

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 325-332

  Mody, Karishma T ^a   Mahony, Donna ^a   Cavallaro, Antonino S ^a   Stahr, Frances ^a   Qiao, Shi Zhang ^a,b   Mahony, Timothy J ^a   Mitter, Neena ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Excipients; Freeze drying; Mesoporous silica nanoparticles; Protein; Stability; Vaccine delivery

Indexed keywords

MACROGOL 8000; MCM 41; NANOPARTICLE; OVALBUMIN; SILICON DIOXIDE; TREHALOSE; ANTIGEN; DRUG CARRIER; EXCIPIENT; MACROGOL DERIVATIVE; VACCINE; SILICA NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; ENVIRONMENTAL TEMPERATURE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FREEZE DRYING; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STORAGE; X RAY POWDER DIFFRACTION; ANIMAL; BOVINAE; C57BL MOUSE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG STORAGE; IMMUNOLOGY; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; PHARMACEUTICS; POROSITY; PROCEDURES; PROTEIN STABILITY; SUBCUTANEOUS DRUG ADMINISTRATION; TEMPERATURE; TOXICITY; ADSORPTION; ANTIBODY RESPONSE; ANTIBODY TITER; CELL MEMBRANE; CELL VIABILITY; DESORPTION; IMMUNOGENICITY; ISOTHERM; MOLECULAR WEIGHT; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; TH1 CELL; X RAY DIFFRACTION; X RAY PHOTOELECTRON SPECTROSCOPY; ZETA POTENTIAL;

ANIMALS; ANTIGENS; CATTLE; CELL LINE; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; FREEZE DRYING; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNIZATION; INJECTIONS, SUBCUTANEOUS; MICE, INBRED C57BL; NANOPARTICLES; NANOTECHNOLOGY; OVALBUMIN; POLYETHYLENE GLYCOLS; POROSITY; PROTEIN STABILITY; SILICON DIOXIDE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TREHALOSE; VACCINES;

EID: 84898597476     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.01.037     Document Type: Article

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