Clostridium difficile colitis acquired in the intensive care unit: Outcome and prognostic factors

Infection

Volumn 42, Issue 1, 2014, Pages 23-30

  Sabau, L ^a   Meybeck, A ^a   Gois, J ^a   Devos, P ^b   Patoz, P ^a   Boussekey, N ^a   Delannoy, P Y ^a   Chiche, A ^a   Georges, H ^a   Leroy, O ^a  

^a Hopital Dron   (France)

^b Faculté de Médecine Pôle Recherché   (France)

Author keywords

Clostridium difficile; Colitis; Infection; Intensive care

Indexed keywords

ADICILLIN; ALBUMIN; CARBAPENEM; CORTICOSTEROID; HYDROCORTISONE; HYPERTENSIVE FACTOR; METRONIDAZOLE; PENICILLIN DERIVATIVE; PROTON PUMP INHIBITOR; VANCOMYCIN;

ADULT; ALBUMIN BLOOD LEVEL; ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; COLITIS; DISEASE SEVERITY; DRUG TREATMENT FAILURE; DRUG USE; ENTERIC FEEDING; FEMALE; HEMODIALYSIS; HEMOFILTRATION; HOSPITAL ADMISSION; HOSPITAL INFECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTENSIVE CARE UNIT; KIDNEY FAILURE; LENGTH OF STAY; MALE; METABOLIC DISORDER; MORTALITY; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PRESCRIPTION; RENAL REPLACEMENT THERAPY; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SHOCK; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; TREATMENT DURATION;

ADULT; AGED; AGED, 80 AND OVER; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COHORT STUDIES; COLITIS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84898541898     PISSN: 03008126     EISSN: 14390973     Source Type: Journal    
DOI: 10.1007/s15010-013-0492-1     Document Type: Article

References (33)

1. Barbut F, Corthier G, Charpak Y, Cerf M, Monteil H, Fosse T, Trévoux A, De Barbeyrac B, Boussougant Y, Tigaud S, Tytgat F, Sédallian A, Duborgel S, Collignon A, Le Guern ME, Bernasconi P, Petit JC. Prevalence and pathogenicity of Clostridium difficile in hospitalized patients. A French multicenter study. Arch Intern Med. 1996;156:1449-54. (Pubitemid 26226940)
2. Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, Bourgault AM, Nguyen T, Frenette C, Kelly M, Vibien A, Brassard P, Fenn S, Dewar K, Hudson TJ, Horn R, René P, Monczak Y, Dascal A. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med. 2005;353:2442-9. (Pubitemid 41770165)
3. Musa SA, Moran C, Thomson SJ, Cowan ML, McAnulty G, Grounds M, Rahman TM. Clostridium difficile-associated disease acquired in the cardiothoracic intensive care unit. J Cardiothorac Vasc Anesth. 2011;25:263-7.
4. Ang CW, Heyes G, Morrison P, Carr B. The acquisition and outcome of ICU-acquired Clostridium difficile infection in a single centre in the UK. J Infect. 2008;57:435-40.
5. Steering Group on Healthcare Associated Infection. Clostridium difficile infection: how to deal with the problem-a board to ward approach. London: Department of Health. 2008. http://www.hpa.org.uk/consultations/2008/cdiff.htm.
6. Marra AR, Edmond MB, Wenzel RP, Bearman GM. Hospital-acquired Clostridium difficile-associated disease in the intensive care unit setting: epidemiology, clinical course and outcome. BMC Infect Dis. 2007;7:42.
7. McCabe WR, Jackson CG. Gram-negative bacteremia. I. Etiology and ecology. Arch Intern Med. 1962;110:847-55.
8. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40:373-83. (Pubitemid 17055592)
9. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993;270:2957-63. (Pubitemid 24000804)
10. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22:707-10.
11. Teasdale G, Jennet B. Assessment of coma and impaired consciousness. Lancet. 1974;2:81-4.
12. Nguyen NQ, Ching K, Fraser RJ, Chapman MJ, Holloway RH. Risk of Clostridium difficile diarrhoea in critically ill patients treated with erythromycin-based prokinetic therapy for feed intolerance. Intensive Care Med. 2008;34:169-73.
13. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431-55.
14. Morrison RH, Hall NS, Said M, Rice T, Groff H, Brodine SK, Slymen D, Lederman ER. Risk factors associated with complications and mortality in patients with Clostridium difficile infection. Clin Infect Dis. 2011;53:1173-8.
15. Kim ES, Kim YJ, Park CW, Cho KB, Jang BK, Chung WJ, Hwang JS, Park KS. Response failure to the treatment of Clostridium difficile infection and its impact on 30-day mortality. Hepatogastroenterology. 2012;60(123). doi:10.5754/hge12730.
16. Beaulieu M, Williamson D, Pichette G, Lachaine J. Risk of Clostridium difficile-associated disease among patients receiving proton-pump inhibitors in a Quebec medical intensive care unit. Infect Control Hosp Epidemiol. 2007;28:1305-7. (Pubitemid 47596570)
17. Kenneally C, Rosini JM, Skrupky LP, Doherty JA, Hollands JM, Martinez E, McKinzie WE, Murphy T, Smith JR, Micek ST, Kollef MH. Analysis of 30-day mortality for Clostridium difficile-associated disease in the ICU setting. Chest. 2007;132:418-24. (Pubitemid 47282371)
18. Lawrence SJ, Puzniak LA, Shadel BN, Gillespie KN, Kollef MH, Mundy LM. Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol. 2007;28:123-30. (Pubitemid 46374151)
19. Zahar JR, Schwebel C, Adrie C, Garrouste-Orgeas M, Français A, Vesin A, Nguile-Makao M, Tabah A, Laupland K, Le-Monnier A, Timsit JF; the OUTCOMEREA study group. Outcome of ICU patients with Clostridium difficile infection. Crit Care. 2012;16:R215.
20. Dodek PM, Norena M, Ayas NT, Romney M, Wong H. Length of stay and mortality due to Clostridium difficile infection acquired in the intensive care unit. J Crit Care. 2013 [Epub ahead of print].
21. Johnson S. Recurrent Clostridium difficile infection: causality and therapeutic approaches. Int J Antimicrob Agents. 2009;33:S33-6.
22. Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis. 2007;45:302-7. (Pubitemid 47101025)
23. Musher DM, Aslam S. Treatment of Clostridium difficile colitis in the critical care setting. Crit Care Clin. 2008;24:279-91. (Pubitemid 351400618)
24. O'Grady NP, Barie PS, Bartlett JG, Bleck T, Carroll K, Kalil AC, Linden P, Maki DG, Nierman D, Pasculle W, Masur H; American College of Critical Care Medicine; Infectious Diseases Society of America. Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med. 2008;36:1330-49. (Pubitemid 351482685)
25. Micek ST, Roubinian N, Heuring T, Bode M, Williams J, Harrison C, Murphy T, Prentice D, Ruoff BE, Kollef MH. Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med. 2006;34:2707-13. (Pubitemid 44610934)
26. Minne L, Abu-Hanna A, de Jonge E. Evaluation of SOFA-based models for predicting mortality in the ICU: a systematic review. Crit Care. 2008;12:R161.
27. Bobo LD, Dubberke ER, Kollef M. Clostridium difficile in the ICU: the struggle continues. Chest. 2011;140:1643-53.
28. Wilson V, Cheek L, Satta G, Walker-Bone K, Cubbon M, Citron D, Gerding DN, Llewelyn MJ. Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom. Clin Infect Dis. 2010;50:e77-81.
29. Bloomfield MG, Sherwin JC, Gkrania-Klotsas E. Risk factors for mortality in Clostridium difficile infection in the general hospital population: a systematic review. J Hosp Infect. 2012;1:1-12.
30. Fujitani S, George WL, Murthy AR. Comparison of clinical severity score indices for Clostridium difficile infection. Infect Control Hosp Epidemiol. 2011;32:220-8.
31. Lungulescu OA, Cao W, Gatskevich E, Tlhabano L, Stratidis JG. CSI: a severity index for Clostridium difficile infection at the time of admission. J Hosp Infect. 2011;79:151-4.
32. Venugopal AA, Johnson S. Fidaxomicin: a novel macrocyclic antibiotic approved for treatment of Clostridium difficile infection. Clin Infect Dis. 2012;54:568-74.
33. Mullane KM, Miller MA, Weiss K, Lentnek A, Golan Y, Sears PS, Shue YK, Louie TJ, Gorbach SL. Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections. Clin Infect Dis. 2011;53:440-7.