Outcome of ICU patients with Clostridium difficile infection

Critical Care

Volumn 16, Issue 6, 2012, Pages

  Zahar, Jean Ralph ^a,b   Schwebel, Carole ^e   Adrie, Christophe ^c   Garrouste Orgeas, Maité ^a,d   Français, Adrien ^a   Vesin, Aurélien ^a   Nguile Makao, Molière ^a   Tabah, Alexis ^a,e   Laupland, Kevin ^a,f   Le Monnier, Alban ^g,h   Timsit, Jean François ^a,c,e  

^a INSTITUT ALBERT BONNIOT   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c DELAFONTAINE HOSPITAL   (France)

^d SAINT JOSEPH HOSPITAL   (France)

^e Albert Michallon Teaching Hospital   (France)

^f Peter Lougheed Centre   (Canada)

^g CENTRE HOSPITALIER DE VERSAILLES   (France)

^h University Paris Sud   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; METRONIDAZOLE; VANCOMYCIN; ANTIINFECTIVE AGENT;

ABNORMAL FECES; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL STRAIN; CLINICAL ASSESSMENT; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DIARRHEA; FECES CULTURE; FEMALE; HAZARD RATIO; HOSPITAL ADMISSION; HOSPITAL INFECTION; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE PRICING; SEPTIC SHOCK; WATERY STOOL; CLOSTRIDIUM INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; MIDDLE AGED; PEPTOCLOSTRIDIUM DIFFICILE; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

AGED; ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; FEMALE; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; METRONIDAZOLE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84868238111     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11852     Document Type: Article

References (28)

1. Pepin J, Valiquette L, Cossette B. Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ 2005, 173:1037-1042. 10.1503/cmaj.050978, 1266326, 16179431.
2. Zilberberg MD, Shorr AF, Kollef MH. Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005. Emerg Infect Dis 2008, 14:929-931. 10.3201/eid1406.071447, 2600276, 18507904.
3. Ramaswamy R, Grover H, Corpuz M, Daniels P, Pitchumoni CS. Prognostic criteria in Clostridium difficile colitis. Am J Gastroenterol 1996, 91:460-464.
4. Kyne L, Hamel MB, Polavaram R, Kelly CP. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 2002, 34:346-353. 10.1086/338260, 11774082.
5. Pepin J, Valiquette L, Alary ME, Villemure P, Pelletier A, Forget K, Pépin K, Chouinard D. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004, 171:466-472. 10.1503/cmaj.1041104, 514643, 15337727.
6. Bishara J, Peled N, Pitlik S, Samra Z. Mortality of patients with antibiotic-associated diarrhoea: the impact of Clostridium difficile. J Hosp Infect 2008, 68:308-314. 10.1016/j.jhin.2008.01.033, 18353491.
7. Ang CW, Heyes G, Morrison P, Carr B. The acquisition and outcome of ICU-acquired Clostridium difficile infection in a single centre in the UK. J Infect 2008, 57:435-440. 10.1016/j.jinf.2008.10.002, 19013649.
8. Kenneally C, Rosini JM, Skrupky LP, Doherty JA, Hollands JM, Martinez E, McKinzie WE, Murphy T, Smith JR, Micek ST, Kollef MH. Analysis of 30-day mortality for Clostridium difficile-associated disease in the ICU setting. Chest 2007, 132:418-424. 10.1378/chest.07-0202, 17573523.
9. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997, 32:920-924. 10.3109/00365529709011203, 9299672.
10. Planche T, Aghaizu A, Holliman R, Riley P, Poloniecki J, Breathnach A, Krishna S. Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect Dis 2008, 8:777-784. 10.1016/S1473-3099(08)70233-0, 18977696.
11. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 270:2957-2963. 10.1001/jama.1993.03510240069035, 8254858.
12. Timsit JF, Fosse JP, Troche G, De Lassence A, Alberti C, Garrouste-Orgeas M, Bornstain C, Adrie C, Cheval C, Chevret S, . OUTCOMEREA Study Group, France Calibration and discrimination of daily LOD score in predicting hospital mortality of critically ill patients, comparison with daily SOFA score. Crit Care Med 2002, 30:2003-2013. 10.1097/00003246-200209000-00009, 12352033, OUTCOMEREA Study Group, France.
13. Le Gall JR, Klar J, Lemeshow S, Saulnier F, Alberti C, Artigas A, Teres D. The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group. JAMA 1996, 276:802-810. 10.1001/jama.1996.03540100046027, 8769590.
14. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis- Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710. 10.1007/BF01709751, 8844239.
15. Lau B, Cole SR, Gange SJ. Competing risk regression models for epidemiologic data. Am J Epidemiol 2009, 170:244-256. 10.1093/aje/kwp107, 2732996, 19494242.
16. Wolkewitz M, Beyersmann J, Gastmeier P, Schumacher M. Modeling the effect of time-dependent exposure on intensive care unit mortality. Intensive Care Med 2009, 35:826-832. 10.1007/s00134-009-1423-6, 19183943.
17. Darmon M, Timsit JF, Francais A, Nguile-Makao M, Adrie C, Cohen Y, Garrouste-Orgeas M, Goldgran-Toledano D, Dumenil AS, Jamali S, Cheval C, Allaouchiche B, Souweine B, Azoulay E. Association between hypernatraemia acquired in the ICU and mortality: a cohort study. Nephrol Dial Transplant 2010, 25:2510-2515. 10.1093/ndt/gfq067, 20167570.
18. Garrouste Orgeas M, Timsit JF, Soufir L, Tafflet M, Adrie C, Philippart F, Zahar JR, Clec'h C, Goldran-Toledano D, Jamali S, Dumenil AS, Azoulay E, Carlet J, . Outcomerea Study Group Impact of adverse events on outcomes in intensive care unit patients. Crit Care Med 2008, 36:2041-2047. 10.1097/CCM.0b013e31817b879c, 18552694, Outcomerea Study Group.
19. Beyersmann J, Gastmeier P, Grundmann H, Bärwolff S, Geffers C, Behnke M, Rüden H, Schumacher M. Use of multistate models to assess prolongation of intensive care unit stay due to nosocomial infection. Infect Control Hosp Epidemiol 2006, 27:493-499. 10.1086/503375, 16671031.
20. Latouche A, Porcher R, Chevret S. Sample size formula for proportional hazards modelling of competing risks. Stat Med 2004, 23:3263-3274. 10.1002/sim.1915, 15490425.
21. Lawrence SJ, Puzniak LA, Shadel BN, Gillespie KN, Kollef MH, Mundy LM. Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol 2007, 28:123-130. 10.1086/511793, 17265392.
22. Harris AD, Samore MH, Carmeli Y. Control group selection is an important but neglected issue in studies of antibiotic resistance. Ann Intern Med 2000, 133:159.
23. Wacholder S, Silverman DT, McLaughlin JK, Mandel JS. Selection of controls in case-control studies. II. Types of controls. Am J Epidemiol 1992, 135:1029-1041.
24. McDonald LC, Killgore GE, Thompson A, Owens RC, Kazakova SV, Sambol SP, Johnson S, Gerding DN. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005, 353:2433-2441. 10.1056/NEJMoa051590, 16322603.
25. McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg Infect Dis 2006, 12:409-415. 10.3201/eid1203.051064, 3291455, 16704777.
26. Timsit JF, Zahar JR, Chevret S. Attributable mortality of ventilator-associated pneumonia. Curr Opin Crit Care 2011, 17:464-471. 10.1097/MCC.0b013e32834a5ae9, 21844801.
27. Crobach MJ, Dekkers OM, Wilcox MH, Kuijper EJ. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect 2009, 15:1053-1066. 10.1111/j.1469-0691.2009.03098.x, 19929972.
28. Gerding DN, Muto CA, Owens RC. Treatment of Clostridium difficile infection. Clin Infect Dis 2008, 46(Suppl 1):S32-42.