Treatment effect of Bushen Huayu extract on postmenopausal osteoporosis in vivo

Experimental and Therapeutic Medicine

Volumn 7, Issue 6, 2014, Pages 1687-1690

  Ouyang, Lu ^a   Zhang, Qiufang ^a   Ruan, Xuzhi ^a   Feng, Yibin ^b   Wang, Xuanbin ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Alkaline phosphatase; Estradiol; Interleukin 6; Nilestriol; Traditional Chinese medicine

Indexed keywords

ALKALINE PHOSPHATASE; BUSHEN HUAYU EXTRACT; ESTRADIOL; ESTROGEN; HERBACEOUS AGENT; ICARIIN; INTERLEUKIN 6; MISCELLANEOUS DRUGS AND AGENTS; NILESTRIOL; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE INJURY; BONE MARROW; BONE METABOLISM; CONTROLLED STUDY; DRUG MEGADOSE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; HERBAL MEDICINE; LOW DRUG DOSE; MICROSCOPY; MORPHOLOGY; MULTIPLE DRUG DOSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; RAT; TRABECULAR BONE;

EID: 84898493500     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1661     Document Type: Article

References (18)

1. Cavalli L and Brandi ML: Age-and gender-related macro- and micro-architecture changes in bone structure and implications for treatment. Int J Clin Rheumatol 6: 359-369, 2011.
2. Lindsay R: Hormones and bone health in postmenopausal women. Endocrine 24: 223-230, 2004.
3. Sanders S and Geraci SA: Osteoporosis in postmenopausal women: considerations in prevention and treatment: (women's health series). South Med J 106: 698-706, 2013.
4. Yoldemir T, Erenus M and Durmusoglu F: The impact of serum FSH and estradiol on postmenopausal osteoporosis related to time since menopause. Gynecol Endocrinol 28: 884-888, 2012.
5. Ouyang L, Wang X, Li H and Xiao Y: Determination of Icariin in Bushenhuayu Electuary by HPLC. Zhong Guo Yao Shi 13: 13-15, 2010.(In Chinese).
6. Joo MK, Park JJ, Lee BJ, Kim JH, Yeon JE, Kim JS, Byun KS and Bak YT: The effect of a proton pump inhibitor on bone metabolism in ovariectomized rats. Mol Med Rep 7: 1267-1272, 2013.
7. Rachner TD, Khosla S and Hofbauer LC: Osteoporosis: now and the future. Lancet 377: 1276-1287, 2011.
8. Craft CS, Broekelmann TJ, Zou W, Chappel JC, Teitelbaum SL and Mecham RP: Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice. J Cell Biochem 113: 93-99, 2012.
9. Kwak EJ, Lee YS and Choi EM: Effect of magnolol on the function of osteoblastic MC3T3-E1 cells. Mediators Inflamm 2012: 829650, 2012.
10. Wang M, Ling G, Bei X, Junqing C, Peiqing Z and Jie H: Clinical observation on 96 cases of primary osteoporosis treated with kidney-tonifying and bone-strengthening mixture. J Tradit Chin Med 25: 132-136, 2005.
11. Hsieh TP, Sheu SY, Sun JS and Chen MH: Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE(2) synthesis. Phytomedicine 18: 176-185, 2011.
12. McLean RR: Proinflammatory cytokines and osteoporosis. Curr Osteoporos Rep 7: 134-139, 2009.
13. Mysliwiec J, Adamczyk M, Nikolajuk A and Gorska M: Interleukin-6 and its considerable role in the pathogenesis of thyrotoxicosis-related disturbances of bone turnover in postmenopausal women. Endokrynol Pol 62: 299-302, 2011.
14. Wang Y, Li LZ, Zhang YL, Zhu YQ, Wu J and Sun WJ: LC, a novel estrone-rhein hybrid compound, concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production by human osteoblastic cells. Mol Cell Endocrinol 337: 43-51, 2011.
15. Eastell R, Reid DM, Vukicevic S, Ensrud KE, LaCroix AZ, Thompson JR, Thompson DD and Cummings SR: Effects of 3 years of lasofoxifene treatment on bone turnover markers in women with postmenopausal osteoporosis. Bone 50: 1135-1140, 2012.
16. Song Y, Li SH, He ZJ, Zhang YW and Zhou MW: Effect of icariin on osteoporosis in ovariectomized female rats. Jun Yi Jin Xiu Xue Yuan Xue Bao 33: 400-403, 2012.(In Chinese).
17. Yang L, Lu D, Guo J, Meng X, Zhang G and Wang F: Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19). J Ethnopharmacol 145: 715-721, 2012.
18. Zhang S, Liu X, Zheng S, Jiang M, Xin C, Lu X, Li F and Xiong Z: Metabonomic study on protective effect of ethanol extracts of drynariae rhizoma on osteoporosis in rats urine by using UPLC-MS/MS. Zhongguo Zhong Yao Za Zhi 37: 658-662, 2012.(In Chinese).