Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 57-68

  Cappoen, Davie ^a   Jacobs, Jan ^b   Nguyen Van, Tuyen ^b   Claessens, Sven ^b   Diels, Gaston ^c   Anthonissen, Roel ^a   Einarsdottir, Thorbjorg ^a   Fauville, Maryse ^a   Verschaeve, Luc ^d   Huygen, Kris ^a   De Kimpe, Norbert ^b  

^a OD Communicable and Infectious Diseases   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^d SCIENTIFIC INSTITUTE OF PUBLIC HEALTH   (Belgium)

Author keywords

Anti mycobacterial activity; Benz g isoquinoline 5,10 dione; Benzo j phenanthridine 7,12 dione; Cytotoxicity; Heck reaction; Intracellular pathogen; Mycobacterium tuberculosis

Indexed keywords

2 CHLOROBENZO[J]PHENANTHRIDINE 7,12 DIONE; 2 FLUOROBENZO[J]PHENANTHRIDINE 7,12 DIONE; 2 METHOXYBENZO[J]PHENANTHRIDINE 7,12 DIONE; 2 METHYLBENZO[J]PHENANTHRIDINE 7,12 DIONE; 3 METHYLBENZO[J]PHENANTHRIDINE 7,12 DIONE; 4 METHOXYBENZO[J]PHENANTHRIDINE 7,12 DIONE; 4 METHYLBENZO[J]PHENANTHRIDINE 7,12 DIONE; BENZO[J]PHENANTHRIDINE 7,12 DIONE DERIVATIVE; ISONIAZID; PALLADIUM; PROTIONAMIDE; RIFABUTIN; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; CELL SURVIVAL; COMET ASSAY; HEPATOCYTES; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PALLADIUM; PHENANTHRIDINES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84856018140     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.033     Document Type: Article

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