Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells

Cancer Science

Volumn 105, Issue 4, 2014, Pages 418-424

  Ju, Xiaoli ^a   Ishikawa, Tomo o ^a   Naka, Kazuhito ^a   Ito, Kosei ^b   Ito, Yoshiaki ^c   Oshima, Masanobu ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Gastric cancer; RUNX3; TCF4; Wnt signaling; catenin

Indexed keywords

AXIN; AXIN 2 PROTEIN; BETA CATENIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CELL SELECTION; COLONY FORMATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE AMPLIFICATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; ONCOGENE C MYC; POPULATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

GASTRIC CANCER; RUNX3; TCF4; WNT SIGNALING; Β-CATENIN;

AXIN PROTEIN; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA CATENIN; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 3 SUBUNIT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MYC; STOMACH NEOPLASMS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; WNT SIGNALING PATHWAY;

EID: 84898464180     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12356     Document Type: Article

References (27)

1. Li QL, Ito K, Sakakura C et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002; 109: 113-24.
2. Blyth K, Cameron ER, Neil JC. The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer 2005; 5: 376-87.
3. Chuang LSH, Ito K, Ito Y. RUNX family: regulation and diversification of roles through interacting proteins. Int J Cancer 2013; 132: 1260-71.
4. Chuang LSH, Ito Y. RUNX3 is multifunctional in carcinogenesis of multiple solid tumors. Oncogene 2010; 29: 2605-15.
5. Ito K, Liu Q, Salto-Tellez M et al. RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res 2005; 65: 7743-50.
6. Guo WH, Weng LQ, Ito K et al. Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor. Oncogene 2002; 21: 8351-5.
7. -/- gastric epithelial cells differentiate into intestinal type cells. Biochem Biophys Res Commun 2004; 321: 58-64.
8. Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell 2012; 149: 1192-205.
9. Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C, Taketo M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci USA 1995; 92: 4482-6.
10. Harada N, Tamai Y, Ishikawa T et al. Intestinal polyposis in mice with a dominant stable mutation of the β-catenin gene. EMBO J 1999; 18: 5931-42.
11. 2 pathway. Gastroenterology 2006; 131: 1086-95.
12. Ito K, Lim AC, Salto-Tellez M et al. RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell 2008; 14: 226-37.
13. Ito K, Chuang LSH, Ito T et al. Loss of Runx3 is a key event in inducing precancerous state of the stomach. Gastroenterology 2011; 140: 1536-46.
14. Proffitt KD, Madan B, Ke Z et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res 2012; 73: 502-7.
15. Nateri AS, Spencer-Dene B, Behrens A. Integration of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005; 473: 281-5.
16. Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F. Wnt/β-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 2002; 22: 1172-83.
17. Nojima M, Suzuki H, Toyota M et al. Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene 2007; 26: 4699-713.
18. Oguma K, Oshima H, Aoki M et al. Activated macrophages promotes Wnt signalling through tumour necrosis factor-α in gastric tumour cells. EMBO J 2008; 27: 1671-81.
19. Sakakura C, Hasegawa K, Miyagawa K et al. Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancer. Clin Cancer Res 2005; 11: 6479-88.
20. WAF1/Cip1 expression in cooperation with transforming growth factor β-ctivated SMAD. Mol Cell Biol 2005; 25: 8097-107.
21. Cadigan KM, Waterman ML. TCF/LEFs and Wnt signaling in nucleus. Cold Spring Harb Perspect Biol 2012; 4: a007906.
22. Cadigan KM. TCFs and Wnt/β-catenin signaling: more than one way to throw the switch. Curr Top Dev Biol 2012; 98: 1-34.
23. Li J, Wang CY. TBL1-TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nat Cell Biol 2008; 10: 160-9.
24. Benchabane H, Xin N, Tian A et al. Jerky/Earthbound facilitates cell-specific Wnt/Wngless signaling by modulating β-catenin-TCF activity. EMBO J 2011; 30: 1444-58.
25. Nagahama Y, Ishimaru M, Osaki M et al. Apoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN-1. Cancer Sci 2008; 99: 23-30.
26. Tsunematsu T, Kudo Y, Iizuka S et al. RUNX3 has an oncogenic role in head and neck cancer. PLoS ONE 2009; 4: e5892.
27. Kudo Y, Tsunematsu T, Takata T. Oncogenic role of RUNX3 in head and neck cancer. J Cell Biochem 2011; 112: 387-93.