Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6)

Interdisciplinary Toxicology

Volumn 6, Issue 4, 2013, Pages 198-202

  Pohanka, Miroslav ^a   Sobotka, Jakub ^a   Svobodova, Hana ^a   Stetina, Rudolf ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Blister agent; Cholinergic anti inflammatory pathway; Oxidative insult; Reactive oxygen species

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; GLUTATHIONE; GLUTATHIONE REDUCTASE; MUSTARD GAS; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; NONHUMAN; OXIDATIVE STRESS; RAT; WISTAR RAT;

EID: 84898453151     PISSN: 13376853     EISSN: 13379569     Source Type: Journal    
DOI: 10.2478/intox-2013-0029     Document Type: Article

References (20)

1. Bhattacharya R, Rao PV, Pant SC, Kumar P, Tulsawani RK, Pathak U, Kulkami A, Vijayaraghavan R. (2001). Protective effects of amifostine and its analogues on sulfur mustard toxicity in vitro and in vivo. Toxicol Appl Pharmacol 176: 24-33. (Pubitemid 32977288)
2. Bogavac M, Lakic N, Simin N, Nikoilc A, Sudji J, Boin B. (2012). Biomarkers of oxidative stress in amniotic fluid and complications in pregnancy. J Matern Fetal Neonatal Med 25(1): 104-108.
3. Catala A. (2011). Lipid peroxidation of membrane phospholipids in the vertebrate retina. Front Biosci 3: 52-60.
4. Chen HC, Bai DY, Jiang YP. (1996). Effects of HI-6 on muscle acetylcholine receptor: analysis on minimal reaction model. Zhongguo Yao Li Xue Bao 17: 428-431.
5. Collins A, Oscoz1 AA, Brunborg G, Gaiva I, Giovannelli L, Kruszewski M, Smith C, Stetina R. (2008). The comet assay: topical issues. Mutagenesis 23: 143-151.
6. Gautam A, Gupta A, Lomash V, Pant SC, Vijayaraghavan R. (2010). Prophylactic efficacy of combination of DRDE-07 and its analogues with amifostine against sulphur mustard induced systemic toxicity. Indian J Exp Biol 48: 752-761.
7. Gautam A, Vijayaraghavan R. (2007). Prophylactic effect of gossypin against percutaneously administered sulfur mustard. Biomed Environ Sci 20: 250-259. (Pubitemid 47253851)
8. Korkamaz A, Kunak ZI, Paredes SD, Yaren H, Tan DX, Reiter RJ. (2008b). The use of melatonin to combat mustard toxicity. Neuroendocrinol Lett 29: 614-619.
9. Korkmaz A, Yaren H, Kunak Z, Uysal B, Kurt B, Topal T, Kenar L, Ucar E, Oter S. (2008a). Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results. Interdiscip Toxicol 1: 236-241.
10. Oke SL, Tracey KJ. (2009). The inflammatory reflex and the role of complementary and alterantive medical therapies. Ann NY Acad Sci 1172: 172-180.
11. Paromov V, Suntres Z, Smith M, Stone WL. (2007). Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy. J Burns Wounds 7: e7.
12. Pohanka M. (2011). Cholinesterases, a target of pharmacology and toxicology. Biomed Pap Olomouc 155: 219-230.
13. Pohanka M. (2012). Alpha7 nicotinic acetylcholne receptor is a target in pharmacology and toxicology. Int J Mol Sci 13: 2219-2238.
14. Pohanka M, Sobotka J, Stetina R. (2011a). Sulfur mustard induced oxidative stress and its alteration by epigallocatechin gallate. Toxicol Lett 201: 105-109.
15. Pohanka M, Sobotka J, Svobodova H, Stetina R. (2011b). Investigation of oxidative stress in blood, brain, kidney, and liver after oxime antidote HI-6 application in a mouse experimental model. Drug Chem Toxicol 34: 255-260.
16. Pohanka M, Sobotka J, Jilkova M, Stetina R. (2011c). Oxidative stress after sulfur mustard intoxication and its reduction by melatonin: efficacy of antioxidant therapy during serious intoxication. Drug Chem Toxicol 34: 85-91.
17. Shohrati M, Ghanei M, Shamspour N, Babaei F, Abadi MN, Jafari M, Harandi AA. (2009). Glutathione and malondialdehyde levels in late pulmonary complications of sulfur mustard intoxication. Lung 188: 77-83.
18. Shohrati M, Ganei M, Shamspour N, Jafari M. (2008). Activity and function in lung injuries due to sulphur mustard. Biomarkers 13: 728-733.
19. Tewari-Singh N, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. (2011). Effi- cacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo. J Pharmacol Exp Ther 336: 450-459.
20. Wagner S, Kufleitner J, Zensi A, Dadparvar M, Wien S, Bungert J, Vogel T, Worek F, Kreiter J, von Briesen H. (2010). Nanoparticulate transport of oximes over an in vitro blood-brain barrier model. PLoS One 5: e14213.