African ancestry influences CCR5 -2459G>A genotype-associated virologic success of highly active antiretroviral therapy

Journal of Acquired Immune Deficiency Syndromes

Volumn 66, Issue 1, 2014, Pages 102-107

  Cheruvu, Vinay K ^a   Igo, Robert P ^b   Jurevic, Richard J ^c,e   Serre, David ^d   Zimmerman, Peter A ^b   Rodriguez, Benigno ^b   Mehlotra, Rajeev K ^b  

^a KENT STATE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e West Virginia University School of Dentistry   (United States)

Author keywords

African American; ancestry informative markers; CCR5; HAART; virologic success

Indexed keywords

ANTIRETROVIRUS AGENT; CHEMOKINE RECEPTOR CCR5; DNA;

ADULT; AFRICAN AMERICAN; ALLELE; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENOTYPE; HAPLOTYPE MAP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PHARMACOGENOMICS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; VIRUS LOAD;

ADULT; AFRICAN AMERICANS; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; FEMALE; GENOTYPE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; RECEPTORS, CCR5; TIME FACTORS; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84898426941     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000129     Document Type: Article

References (39)

1. Marconi VC, Grandits G, Okulicz JF, et al. Cumulative viral load and virologic decay patterns after antiretroviral therapy in HIV-infected subjects influence CD4 recovery and AIDS. PLoS One. 2011;6:e17956.
2. Mehlotra RK, Cheruvu VK, Blood Zikursh MJ, et al. Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success. J Infect Dis. 2011;204:291-298.
3. Gonzalez E, Bamshad M, Sato N, et al. Race-specific HIV-1 diseasemodifying effects associated with CCR5 haplotypes. Proc Natl Acad Sci U S A. 1999;96:12004-12009.
4. Chakraborty R. Gene admixture in human populations: models and predictions. Am J Phys Anthropol. 1986;29:1-43.
5. Deo RC, Reich D, Tandon A, et al. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 2009;5:e1000342.
6. Parra EJ. Admixture in North America. In: Suarez-Kurtz G, ed. Pharmacogenomics in Admixed Populations. Austin, TX: Landes Bioscience; 2007:28-46.
7. Kidd JR, Friedlaender FR, Speed WC, et al. Analyses of a set of 128 ancestry informative single-nucleotide polymorphisms in a global set of 119 population samples. Investig Genet. 2011;2:1.
8. Kosoy R, Nassir R, Tian C, et al. Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. Hum Mutat. 2009;30:69-78.
9. Cheng CY, Reich D, Haiman CA, et al. African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts. PLoS One. 2012;7:e32840.
10. Deo RC, Wilson JG, Xing C, et al. Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans. PLoS One. 2011;6:e14581.
11. Kao WH, Klag MJ, Meoni LA, et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008;40: 1185-1192.
12. Price AL, Patterson N, Hancks DC, et al. Effects of cis and trans genetic ancestry on gene expression in African Americans. PLoS Genet. 2008;4: e1000294.
13. Rumpel JA, Ahmedani BK, Peterson EL, et al. Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma. J Allergy Clin Immunol. 2012;130:1302-1306.
14. Schlesinger D, Grinberg LT, Alba JG, et al. African ancestry protects against Alzheimer's disease-related neuropathology. Mol Psychiatry. 2013;18:79-85.
15. Falush D, Stephens M, Pritchard JK. Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics. 2003;164:1567-1587.
16. Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics. 2000;155:945-959.
17. Cox DR. Regression models and life tables. J R Stat Soc [B]. 1972;34: 187-220.
18. Clark VJ, Dean M. Haplotype structure and linkage disequilibrium in chemokine and chemokine receptor genes. Hum Genomics. 2004;1:255- 273.
19. Zakharia F, Basu A, Absher D, et al. Characterizing the admixed African ancestry of African Americans. Genome Biol. 2009;10:R141.
20. Frasco MA, Mack WJ, Van Den Berg D, et al. Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine. AIDS. 2012;26:2097-2106.
21. Nicholaou MJ, Martinson JJ, Abraham AG, et al. HAART-associated dyslipidemia varies by biogeographical ancestry in the multicenter AIDS cohort study. AIDS Res Hum Retroviruses. 2013;29:871-879.
22. Palmer JR, Ruiz-Narvaez EA, Rotimi CN, et al. Genetic susceptibility loci for subtypes of breast cancer in an African American population. Cancer Epidemiol Biomarkers Prev. 2013;22:127-134.
23. Qi L, Nassir R, Kosoy R, et al. Relationship between hysterectomy and admixture in African American women. Am J Obstet Gynecol. 2013;208: 279.e1-279.e7.
24. Wise LA, Ruiz-Narvaez EA, Palmer JR, et al. African ancestry and genetic risk for uterine leiomyomata. Am J Epidemiol. 2012;176: 1159-1168.
25. An P, Li R, Wang JM, et al. Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. PLoS Genet. 2011;7:e1002328.
26. Gonzalez E, Dhanda R, Bamshad M, et al. Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic. Proc Natl Acad Sci U S A. 2001;98: 5199-5204.
27. Gonzalez E, Kulkarni H, Bolivar H, et al. The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science. 2005;307:1434-1440.
28. McDermott DH, Beecroft MJ, Kleeberger CA, et al. Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study. AIDS. 2000;14:2671-2678.
29. van Manen D, van 't Wout AB, Schuitemaker H. Genome-wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics. Retrovirology. 2012;9:70.
30. Ansari-Lari MA, Liu XM, Metzker ML, et al. The extent of genetic variation in the CCR5 gene. Nat Genet. 1997;16:221-222.
31. Carrington M, Dean M, Martin MP, et al. Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum Mol Genet. 1999;8:1939-1945.
32. Carrington M, Kissner T, Gerrard B, et al. Novel alleles of the chemokine-receptor gene CCR5. Am J Hum Genet. 1997;61:1261-1267.
33. Blanpain C, Lee B, Tackoen M, et al. Multiple nonfunctional alleles of CCR5 are frequent in various human populations. Blood. 2000;96:1638- 1645.
34. Howard OM, Shirakawa AK, Turpin JA, et al. Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 co-receptor and ligand binding function. J Biol Chem. 1999;274:16228-16234.
35. Tandon A, Patterson N, Reich D. Ancestry informative marker panels for African Americans based on subsets of commercially available SNP arrays. Genet Epidemiol. 2011;35:80-83.
36. O'Connor JL, Gardner EM, Mannheimer SB, et al. Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trial. J Infect Dis. 2013;208:40-49.
37. Oh DL, Sarafian F, Silvestre A, et al. Evaluation of adherence and factors affecting adherence to combination antiretroviral therapy among White, Hispanic, and Black men in the MACS Cohort. J Acquir Immune Defic Syndr. 2009;52:290-293.
38. Mountain JL, Risch N. Assessing genetic contributions to phenotypic differences among "racial" and "ethnic" groups. Nat Genet. 2004;36: S48-S53.
39. Prejean J, Song R, Hernandez A, et al. Estimated HIV incidence in the United States, 2006-2009. PLoS One. 2011;6:e17502.