Inhibition of SENP5 suppresses cell growth and promotes apoptosis in osteosarcoma cells

Experimental and Therapeutic Medicine

Volumn 7, Issue 6, 2014, Pages 1691-1695

  Wang, Kun ^a   Zhang, Xin Chao ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Drug target; Osteosarcoma; SUMO specific protease 5

Indexed keywords

BETA ACTIN; CASPASE 3; CASPASE 7; CYCLIN B1; SMALL INTERFERING RNA; SUMO PROTEIN; SUMO SPECIFIC PROTEASE 5; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GENE THERAPY; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION ASSAY; COLONY FORMATION; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; G2 PHASE CELL CYCLE CHECKPOINT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MRNA EXPRESSION ASSAY; OSTEOSARCOMA; OSTEOSARCOMA CELL; POLYMERASE CHAIN REACTION; POSTTRANSCRIPTIONAL GENE SILENCING; PROTEIN EXPRESSION; PROTEINASE INHIBITION; WESTERN BLOTTING;

EID: 84898421002     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1644     Document Type: Article

References (19)

1. Jaffe N: Osteosarcoma: review of the past, impact on the future. The American experience. Cancer Treat Res 152: 239-262, 2009.
2. Geiss-Friedlander R and Melchior F: Concepts in sumoylation: a decade on. Nat Rev Mol Cell Biol 8: 947-956, 2007.
3. Müller S, Hoege C, Pyrowolakis G and Jentsch S: SUMO, ubiquitin's mysterious cousin. Nat Rev Mol Cell Biol 2: 202-210, 2001.
4. Hannoun Z, Greenhough S, Jaffray E, Hay RT and Hay DC: Post-translational modification by SUMO. Toxicology 278: 288-293, 2010.
5. Hwang KW, Won TJ, Kim H, Chun HJ, Chun T and Park Y: Characterization of the regulatory roles of the SUMO. Diabetes Metab Res Rev 27: 854-861, 2011.
6. Yeh ET: SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem 284: 8223-8227, 2009.
7. Bawa-Khalfe T and Yeh ET: SUMO Losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression. Genes Cancer 1: 748-752, 2010.
8. Kim JH and Baek SH: Emerging roles of desumoylating enzymes. Biochim Biophys Acta 1792: 155-162, 2009.
9. Ding X, Sun J, Wang L, et al: Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep 20: 1041-1045, 2008.
10. Gong L and Yeh ET: Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem 281: 15869-15877, 2006.
11. Zunino R, Braschi E, Xu L and McBride HM: Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis. J Biol Chem 284: 17783-17795, 2009.
12. Di Bacco A and Gill G: SUMO-specific proteases and the cell cycle. An essential role for SENP5 in cell proliferation. Cell Cycle 5: 2310-2313, 2006.
13. Di Bacco A, Ouyang J, Lee HY, Catic A, Ploegh H and Gill G: The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol 26: 4489-4498, 2006.
14. Zunino R, Schauss A, Rippstein P, Andrade-Navarro M and McBride HM: The SUMO protease SENP5 is required to maintain mitochondrial morphology and function. J Cell Sci 120: 1178-1188, 2007.
15. Alarcon-Vargas D and Ronai Z: SUMO in cancer - wrestlers wanted. Cancer Biol Ther 1: 237-242, 2002.
16. Cheng J, Wang D, Wang Z and Yeh ET: SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol 24: 6021-6028, 2004.
17. Shen HJ, Zhu HY, Yang C and Ji F: SENP2 regulates hepato-cellular carcinoma cell growth by modulating the stability of β-catenin. Asian Pac J Cancer Prev 13: 3583-3587, 2012.
18. Han Y, Huang C, Sun X, et al: SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem 285: 12906-12915, 2010.
19. Qian J, Luo Y, Gu X and Wang X: Inhibition of SENP6-induced radiosensitization of human hepatocellular carcinoma cells by blocking radiation-induced NF-κB activation. Cancer Biother Radiopharm 28: 196-200, 2013.