Inhibition of SENP6-induced radiosensitization of human hepatocellular carcinoma cells by blocking radiation-induced NF-κB activation

Cancer Biotherapy and Radiopharmaceuticals

Volumn 28, Issue 3, 2013, Pages 196-200

  Qian, Jianxin ^a   Luo, Yizhou ^b   Gu, Xiaoqiang ^a   Wang, Xi ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b The 454th Hospital of PLA   (China)

Author keywords

Hepatocellular carcinoma; I B ; NF B; Radiosensitization; SENP6

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEINASE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SMALL UBIQUITIN LIKE MODIFIER SPECIFIC PROTEASE 6; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MOLECULARLY TARGETED THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RADIOSENSITIZATION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYSTEINE ENDOPEPTIDASES; HUMANS; LIVER NEOPLASMS; MOLECULAR TARGETED THERAPY; NF-KAPPA B; RADIATION-SENSITIZING AGENTS; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 84876102465     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2012.1288     Document Type: Article

References (27)

1. Geiss-Friedlander R, Melchior F. Concepts in sumoylation: A decade on. Nat Rev Mol Cell Biol 2007;8:947
2. Anckar J, Sistonen L. SUMO: Getting it on. Biochem Soc Trans 2007;35(Pt 6):1409
3. Sarge KD, Park-Sarge OK. SUMO and its role in human diseases. Int Rev Cell Mol Biol 2011;288:167
4. Hwang KW, Won TJ, Kim H, et al. Characterization of the regulatory roles of the SUMO. Diabetes Metab Res Rev 2011;27:854
5. Wilkinson KA, Henley JM. Mechanisms, regulation and consequences of protein SUMOylation. Biochem J 2010;428:133
6. Ihara M, Koyama H, Uchimura Y, et al. Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth. J Biol Chem 2007;282:16465
7. Kim JH, Baek SH. Emerging roles of desumoylating enzymes. Biochim Biophys Acta 2009;1792:155
8. Bawa-Khalfe T, Yeh ET. SUMO losing balance: SUMO proteases disrupt SUMO homeostasis to facilitate cancer development and progression. Genes Cancer 2010;1:748
9. Dou H, Huang C, Van Nguyen T, et al. SUMOylation and de-SUMOylation in response to DNA damage. FEBS Lett 2011;585:2891
10. Kim KI, Baek SH, Jeon YJ, et al. A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J Biol Chem 2000;275:14102
11. Mukhopadhyay D, Ayaydin F, Kolli N, et al. SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J Cell Biol 2006;174:939
12. Hattersley N, Shen L, Jaffray EG, Hay RT. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Mol Biol Cell 2011;22:78
13. Mukhopadhyay D, Arnaoutov A, Dasso M. The SUMO protease SENP6 is essential for inner kinetochore assembly. J Cell Biol 2010;188:681
14. Dou H, Huang C, Singh M, et al. Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. Mol Cell 2010;39:333
15. Baker RG, Hayden MS, Ghosh S. NF-kappaB, inflammation, and metabolic disease. Cell Metab 2011;13:11
16. Sun SC. Non-canonical NF-kappaB signaling pathway. Cell Res 2011;21:71
17. Razani B, Reichardt AD, Cheng G. Non-canonical NFkappaB signaling activation and regulation: Principles and perspectives. Immunol Rev 2011;244:44
18. Wullaert A, Bonnet MC, Pasparakis M. NF-kappaB in the regulation of epithelial homeostasis and inflammation. Cell Res 2011;21:146
19. Spencer E, Jiang J, Chen ZJ. Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP. Genes Dev 1999;13:284
20. Winston JT, Strack P, Beer-Romero P, et al. The SCFbeta- TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev 1999;13:270
21. Nogueira L, Ruiz-Ontanon P, Vazquez-Barquero A, et al. The NFkappaB pathway: A therapeutic target in glioblastoma. Oncotarget 2011;2:646
22. Morais C, Gobe G, Johnson DW, Healy H. The emerging role of nuclear factor kappa B in renal cell carcinoma. Int J Biochem Cell Biol 2011;43:1537
23. He G, Karin M. NF-kappaB and STAT3- key players in liver inflammation and cancer. Cell Res 2011;21:159
24. Luedde T, Schwabe RF. NF-kappaB in the liver - linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 2011;8:108
25. Beg AA, Baldwin AS, Jr. The I kappa B proteins: Multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev 1993;7:2064
26. Russell JS, Tofilon PJ. Radiation-induced activation of nuclear factor-kappaB involves selective degradation of plasma membrane-associated I(kappa)B(alpha). Mol Biol Cell 2002; 13:3431
27. Sethi G, Shanmugam MK, Ramachandran L, et al. Multifaceted link between cancer and inflammation. Biosci Rep 2012;32:1