Performance of an in situ formed bioactive hydrogel dressing from a PEG-based hyperbranched multifunctional copolymer

Acta Biomaterialia

Volumn 10, Issue 5, 2014, Pages 2076-2085

  Dong, Yixiao ^a   Hassan, Waqar U ^a   Kennedy, Robert ^a   Greiser, Udo ^a   Pandit, Abhay ^b   Garcia, Yolanda ^b   Wang, Wenxin ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Adipose derived stem cells; Hydrogel dressing; In situ cross link; PEG based hyperbranched polymer; Wound healing

Indexed keywords

CYTOLOGY; DENDRIMERS; HYALURONIC ACID; HYDROGELS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

ADIPOSE DERIVED STEM CELLS; BIOACTIVE HYDROGELS; CELL VIABILITY; HYDROGELS DRESSINGS; HYPERBRANCHED; HYPERBRANCHED POLYMERS; IN SITU CROSS-LINK; IN-VITRO; POLYETHYLENE GLYCOL BASED HYPERBRANCHED POLYMER; WOUND HEALING;

STEM CELLS;

COPOLYMER; HYALURONIC ACID; MACROGOL; BIOMATERIAL; HYDROGEL; MACROGOL DERIVATIVE;

ADIPOSE DERIVED STEM CELL; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL ENCAPSULATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; EPITHELIZATION; HYBRID; HYDROGEL DRESSING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WOUND; WOUND CLOSURE; WOUND CONTRACTION; WOUND HEALING; ADIPOSE TISSUE; ANIMAL; BANDAGE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM; HYDROGEL; MACROPHAGE; METABOLISM; PATHOLOGY; PHARMACOLOGY; SPRAGUE DAWLEY RAT; STEM CELL; STEM CELL TRANSPLANTATION;

RATTUS;

ADIPOSE TISSUE; ANIMALS; BANDAGES; BIOCOMPATIBLE MATERIALS; CELL PROLIFERATION; CELL SURVIVAL; EPITHELIUM; HYALURONIC ACID; HYDROGEL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGES; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; STEM CELL TRANSPLANTATION; STEM CELLS; WOUND HEALING;

EID: 84898059227     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.12.045     Document Type: Article

References (44)

1. K. Lay-Flurrie The properties of hydrogel dressings and their impact on wound healing Prof Nurse 19 2004 269 273
2. J.S. Boateng, K.H. Matthews, H.N.E. Stevens, and G.M. Eccleston Wound healing dressings and drug delivery systems: a review J Pharm Sci 97 2008 2892 2923
3. R.G. Sibbald, H. Orsted, G.S. Schultz, P Coutts, D. Keast, and International Wound Bed Preparation Advisory B et al. Preparing the wound bed 2003: focus on infection and inflammation Ostomy Wound Manage 2003 49 2003 23 51
4. P. Martin Wound healing - aiming for perfect skin regeneration Science 276 1997 75 81
5. E.M.H. Mathus-Vliegen Old age, malnutrition, and pressure sores: an III-fated alliance J Gerontol Ser A Biol Sci Med Sci 59 2004 355 360
6. A. Freiman, G. Bird, A.I. Metelitsa, B. Barankin, and G.J. Lauzon Cutaneous effects of smoking J Cutan Med Surg 8 2004 415 423
7. D.R. Thomas Improving outcome of pressure ulcers with nutritional interventions: a review of the evidence Nutrition 17 2001 121 125
8. S. Hampton A small study in healing rates and symptom control using a new sheet hydrogel dressing J Wound Care 13 2004 297 300
9. G.M. Zentner, R. Rathi, C. Shih, J.C. McRea, M.H. Seo, and H. Oh et al. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs J. Controlled Release 72 2001 203 215
10. D. Eisenbud, H. Hunter, L. Kessler, and K. Zulkowski Hydrogel wound dressings: where do we stand in 2003? Ostomy Wound Manage 49 2003 52 57
11. M.A. Fonder, G.S. Lazarus, D.A. Cowan, B. Aronson-Cook, A.R. Kohli, and A.J. Mamelak Treating the chronic wound: a practical approach to the care of nonhealing wounds and wound care dressings J Am Acad Dermatol 58 2008 185 206
12. C. Fathke, L. Wilson, J. Hutter, V. Kapoor, A. Smith, and A. Hocking et al. Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair Stem Cells 22 2004 812 822
13. X. Fu, and H. Li Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions Cell Tissue Res 335 2009 317 321
14. C.M. Kolf, E. Cho, and R.S. Tuan Mesenchymal stromal cells - biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation Arthr Res Ther 9 2007 204
15. Y. Wu, J. Wang, P.G. Scott, and E.E. Tredget Bone marrow-derived stem cells in wound healing: a review Wound Repair Regen 15 2007 S18 S26
16. F. Lu, H. Mizuno, C.A. Uysal, X. Cai, R. Ogawa, and H. Hyakusoku Improved viability of random pattern skin flaps through the use of adipose-derived stem cells Plast Reconstr Surg 121 2008 50 58
17. M.H. Moon, S.Y. Kim, Y.J. Kim, S.J. Kim, J.B. Lee, and Y.C. Bae et al. Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia Cell Physiol Biochem 17 2006 279 290
18. J. Rehman, D. Traktuev, J.L. Li, S. Merfeld-Clauss, C.J. Temm-Grove, and J.E. Bovenkerk et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells Circulation 109 2004 1292 1298
19. Y.-H. Song, S. Gehmert, S. Sadat, K. Pinkernell, X. Bai, and N. Matthias et al. VEGF is critical for spontaneous differentiation of stem cells into cardiomyocytes Biochem Biophys Res Commun 354 2007 999 1003
20. M. Cherubino, J.P. Rubin, N. Miljkovic, A. Kelmendi-Doko, and K.G. Marra Adipose-derived stem cells for wound healing applications Ann Plast Surg 66 2011 210 215
21. J. Cha, and V. Falanga Stem cells in cutaneous wound healing Clin Dermatol 25 2007 73 78
22. Y. Wu, L. Chen, P.G. Scott, and E.E. Tredget Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis Stem Cells 25 2007 2648 2659
23. L. Chen, E.E. Tredget, P.Y.G. Wu, and Y. Wu Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing Plos One 3 4 2008 e1886
24. W.-S. Kim, B.-S. Park, J.-H. Sung, J.-M. Yang, S.-B. Park, and S.-J. Kwak et al. Wound heating effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts J Dermatol Sci 48 2007 15 24
25. S. Kern, H. Eichler, J. Stoeve, H. Kluter, and K. Bieback Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue Stem Cells 24 2006 1294 1301
26. K. Gonda, T. Shigeura, T. Sato, D. Matsumoto, H. Suga, and K. Inoue et al. Preserved proliferative capacity and multipotency of human adipose-derived stem cells after long-term cryopreservation Plast Reconstr Surg 121 2008 401 410
27. Y. Dong, A.O. Saeed, W. Hassan, C. Keigher, Y. Zheng, and H. Tai et al. "One-step" preparation of thiol-ene clickable PEG-based thermoresponsive hyperbranched copolymer for in situ crosslinking hybrid hydrogel Macromol Rapid Commun 33 2012 120 126
28. M. Slevin, S. Kumar, and J. Gaffney Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses J Biol Chem 277 2002 41046 41059
29. B.P. Toole Hyaluronan: from extracellular glue to pericellular cue Nat Rev Cancer 4 2004 528 539
30. M.A. Solis, Y.-H. Chen, T.Y. Wong, V.Z. Bittencourt, Y.-C. Lin, and L.L. Huang Hyaluronan regulates cell behavior: a potential niche matrix for stem cells Biochem Res Int 2012 2012 11
31. Y. Garcia, B. Wilkins, R.J. Collighan, M. Griffin, and A. Pandit Towards development of a dermal rudiment for enhanced wound healing response Biomaterials 29 2008 857 868
32. R.E. Billingham, and P.B. Medawar Contracture and intussusceptive growth in the healing of extensive wounds in mammalian skin J Anat 89 1955 114 123
33. T.T. Chapman Burn scar and contracture management J Trauma 62 2007 S8
34. G. Gabbiani The myofibroblast in wound healing and fibrocontractive diseases J Pathol 200 2003 500 503
35. G. Hubner, M. Brauchle, H. Smola, M. Madlener, R. Fassler, and S. Werner Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice Cytokine 8 1996 548 556
36. T.P. Amadeu, and A.M.A. Costa Nitric oxide synthesis inhibition alters rat cutaneous wound healing J Cutan Pathol 33 2006 465 473
37. A. Haas Wound healing Dermatol Nurs 7 1995 28 34
38. S.J. Leibovich, and R. Ross Role of macrophage in wound repair - study with hydrocortisone and antimacrophage serum Am J Pathol 78 1975 71 99
39. D.A. Rappolee, D. Mark, M.J. Banda, and Z. Werb Wound macrophages express TGF-Alpha and other growth-factors in vivo - analysis by messenger-RNA phenotyping Science 241 1988 708 712
40. J. Li, Y.P. Zhang, and R.S. Kirsner Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix Microsc Res Tech 60 2003 107 114
41. A.M. Altman, Y. Yan, N. Matthias, X. Bai, C. Rios, and A.B. Mathur et al. IFATS collection: human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model Stem Cells 27 2009 250 258
42. T.G. Ebrahimian, F. Pouzoulet, C. Squiban, V. Buard, M. Andre, and B. Cousin et al. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing Arterioscler Thromb Vasc Biol 29 2009 503 510
43. P.J. Amos, S.K. Kapur, P.C. Stapor, H. Shang, S. Bekiranov, and M. Khurgel et al. Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery Tissue Eng Part A 16 2010 1595 1606
44. W. Hassan, Y. Dong, and W. Wang Encapsulation and 3D culture of human adipose-derived stem cells in an in-situ crosslinked hybrid hydrogel composed of PEG-based hyperbranched copolymer and hyaluronic acid Stem Cell Res Ther 4 2013 32