Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs

Veterinary Parasitology

Volumn 201, Issue 3-4, 2014, Pages 204-206

  Kunkle, Bruce N ^a   Drag, Marlene D ^a   Chester, Theodore S ^a   Larsen, Diane L ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Afoxolaner; Ctenocephalides felis; Curative efficacy; Dog; Speed of kill

Indexed keywords

AFOXOLANER; NEXGARD; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEAGLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; EXPERIMENTAL INFECTION; FEMALE; FLEA BITE; MALE; NONHUMAN; RANDOMIZED CONTROLLED TRIAL;

CANIS FAMILIARIS; CTENOCEPHALIDES FELIS; SIPHONAPTERA (FLEAS);

AFOXOLANER; CTENOCEPHALIDES FELIS; CURATIVE EFFICACY; DOG; SPEED OF KILL;

ADMINISTRATION, ORAL; ANIMALS; ANTIPARASITIC AGENTS; CTENOCEPHALIDES; DOG DISEASES; DOGS; FEMALE; FLEA INFESTATIONS; ISOXAZOLES; MALE; NAPHTHALENES; RANDOM ALLOCATION; TIME;

EID: 84898058895     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2014.02.023     Document Type: Article

References (16)

1. Azad A.F., Radulovic S., Higgins J.A., Noden B.H., Troyer J.M. Flea-borne rickettsioses: ecologic considerations. Emerg. Infect. Dis. 1997, 3:319-327.
2. Beugnet F., Marie J.L. Emerging arthropod borne diseases of companion animals in Europe. Vet. Parasitol. 2009, 163:298-305.
3. Beugnet F., Franc M. Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites. Trends Parasitol. 2012, 28:267-279.
4. Beugnet F. Guide to Vector Borne Diseases of Pets 2013, 425. Ed Merial, France.
5. Carlotti D.N., Jacobs D.E. Therapy, control and prevention of flea allergy dermatitis in dogs and cats. Vet. Dermatol. 2000, 11:83-98.
6. Dryden M.W., Rust M.K. The cat flea: biology, ecology and control. Vet. Parasitol. 1994, 52:1-19.
7. Dumont P. Curative and preventative efficacy of orally administered afoxolaner against dog flea Ctenocephalides canis (Curtis, 1826) infestation in dogs. Vet. Parasitol. 2014, 201:212-215.
8. EMEA Guideline on Good Clinical Practices. The European Agency for the Evaluation of Medicinal Products. VICH Topic GL9 (GCP). (EMWA/CVMP/VICH/595/98-Final) 2000.
9. Hunter J.S., Dumont P., Chester T.S., Young D.R., Fourie J.J., Larsen D.L. Evaluation of the curative and preventive efficacy of a single oral administration of afoxolaner against cat flea Ctenocephalides felis infestations on dogs. Vet. Parasitol. 2014, 201:207-211.
10. Just F.T., Gilles J., Pradel I., Pfalzer S., Lengauer H., Hellmann K., Pfister K. Molecular evidence of Bartonella spp. in cat and dog fleas from Germany and France. Zoo. Public Health 2008, 55(8-10):514-520.
11. Kunkle B., Daly S., Dumont P., Drag M., Larsen D. Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato. Vet. Parasit. 2014, 201:226-228.
12. Letendre L., Huang R., Kvaternick J., Drag M. The intravenious and oral pharmacokinetics of afoxolaner used as a monthly chewable antiparasitic for dogs. Vet. Parasitlol. 2014, 201:190-197.
13. Marchiondo A.A., Holdsworth P.A., Fourie L.J., Rugg D., Kellmann K., Snyder D.E., Dryden M.W. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Vet. Parasitol. 2013, 194:84-97.
14. Mitchell E.B., McCall J.W., Chester S.T., Larsen D. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs. Vet. Parasitol. 2014, 201:223-225.
15. Shoop W.L., Hartline E.J., Gould B.R., Waddell M.E., McDowell R.G., Kinney J.B., Lahm G.P., Long J.K., Xu M., Wagerle T., Jones G.S., Dietrich R.F., Cordova D., Schroeder M.E., Rhoades D.F., Benner E.A., Confalone P.N. Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs. Vet. Parasitol. 2014, 201:179-189.
16. USDA Animal Welfare Regulations, 9CFR 2008, http://awic.nal.usda.gov/government-and-professional-resources/federal-laws/animal-welfare-act.