Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 6, 2014, Pages 1763-1780

  Wohlfarth, Ariane ^a   Gandhi, Adarsh S ^a   Pang, Shaokun ^b   Zhu, Mingshe ^c   Scheidweiler, Karl B ^a   Huestis, Marilyn A ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b MDS SCIEX   (Canada)

^c BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

Author keywords

5F PB 22; High resolution mass spectrometry; Metabolism; PB 22; Synthetic cannabinoids

Indexed keywords

AMINO ACIDS; BIOMOLECULES; DATA HANDLING; ESTERS; HYDROLYSIS; INFORMATION FILTERING; MASS SPECTROMETRY; METABOLISM; POLYCYCLIC AROMATIC HYDROCARBONS; SATURATED FATTY ACIDS;

5F-PB-22; EPOXIDE FORMATIONS; ESTER-BOND LINKAGE; HIGH RESOLUTION MASS SPECTROMETRY; INFORMATION-DEPENDENT ACQUISITIONS; INTERNAL HYDROLYSIS; SYNTHETIC CANNABINOIDS; TOXICOLOGICAL PROPERTIES;

METABOLITES;

3 INDOLECARBOXYLIC ACID; CANNABINOID; INDOLE DERIVATIVE;

ARTICLE; CELL CULTURE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HYDROLYSIS; INDOLE-3-CARBOXYLIC ACID; LIVER CELL; METABOLISM; OXIDATION REDUCTION REACTION; TANDEM MASS SPECTROMETRY;

CANNABINOIDS; CELLS, CULTURED; HEPATOCYTES; HUMANS; HYDROLYSIS; INDOLES; OXIDATION-REDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84898045894     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-7668-0     Document Type: Article

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