Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1

Biochemical and Biophysical Research Communications

Volumn 446, Issue 1, 2014, Pages 387-392

  Shang, Yu ^a,b   Xu, Xialian ^b   Duan, Xiaolin ^c   Guo, Junwei ^b   Wang, Yinyin ^b   Ren, Fangli ^b   He, Dacheng ^a   Chang, Zhijie ^b  

^a BEIJING NORMAL UNIVERSITY   (China)

^b Tsinghua University   (China)

^c Second People Hospital of Zhuhai   (China)

Author keywords

CHIP Stub1; Hsp70; Hsp90; Smad3 ubiquitination and degradation; TGF signal

Indexed keywords

CARBOXYL TERMINUS HEAT SHOCK PROTEIN 70 INTERACTING PROTEIN; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DOWN REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UBIQUITINATION;

CHIP/STUB1; HSP70; HSP90; SMAD3 UBIQUITINATION AND DEGRADATION; TGF-Β SIGNAL;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; HEK293 CELLS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MINK; MULTIPROTEIN COMPLEXES; PROTEOLYSIS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84898010148     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.02.124     Document Type: Article

References (26)

1. J. Massague, S.W. Blain, and R.S. Lo TGFbeta signaling in growth control, cancer, and heritable disorders Cell 103 2000 295 309
2. J. Massague TGFbeta signalling in context Nat. Rev. Mol. Cell Biol. 13 2012 616 630
3. K.J. Gordon, and G.C. Blobe Role of transforming growth factor-beta superfamily signaling pathways in human disease Biochim. Biophys. Acta 1782 2008 197 228
4. T. Imamura, Y. Oshima, and A. Hikita Regulation of TGF-beta family signalling by ubiquitination and deubiquitination J. Biochem. 154 2013 481 489
5. L. Li, H. Xin, X. Xu, M. Huang, X. Zhang, Y. Chen, S. Zhang, X.Y. Fu, and Z. Chang CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription Mol. Cell. Biol. 24 2004 856 864
6. H. Xin, X. Xu, L. Li, H. Ning, Y. Rong, Y. Shang, Y. Wang, X.Y. Fu, and Z. Chang CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation J. Biol. Chem. 280 2005 20842 20850
7. R.F. Li, Y. Shang, D. Liu, Z.S. Ren, Z. Chang, and S.F. Sui Differential ubiquitination of Smad1 mediated by CHIP: implications in the regulation of the bone morphogenetic protein signaling pathway J. Mol. Biol. 374 2007 777 790
8. C.A. Ballinger, P. Connell, Y. Wu, Z. Hu, L.J. Thompson, L.Y. Yin, and C. Patterson Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions Mol. Cell. Biol. 19 1999 4535 4545
9. W. Xu, M. Marcu, X. Yuan, E. Mimnaugh, C. Patterson, and L. Neckers Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu Proc. Natl. Acad. Sci. USA 99 2002 12847 12852
10. V. Tripathi, A. Ali, R. Bhat, and U. Pati CHIP chaperones wild type p53 tumor suppressor protein J. Biol. Chem. 282 2007 28441 28454
11. Z. Liu, L. Ma, Z.S. Wen, Z. Hu, F.Q. Wu, W. Li, J. Liu, and G.B. Zhou Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer Carcinogenesis 2013 10.1093/carcin/bgt395
12. M. Kajiro, R. Hirota, Y. Nakajima, K. Kawanowa, K. So-ma, I. Ito, Y. Yamaguchi, S.H. Ohie, Y. Kobayashi, Y. Seino, M. Kawano, Y. Kawabe, H. Takei, S. Hayashi, M. Kurosumi, A. Murayama, K. Kimura, and J. Yanagisawa The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways Nat. Cell Biol. 11 2009 312 319
13. Y. Shang, X. Zhao, X. Xu, H. Xin, X. Li, Y. Zhai, D. He, B. Jia, W. Chen, and Z. Chang CHIP functions an E3 ubiquitin ligase of Runx1 Biochem. Biophys. Res. Commun. 386 2009 242 246
14. X. Li, M. Huang, H. Zheng, Y. Wang, F. Ren, Y. Shang, Y. Zhai, D.M. Irwin, Y. Shi, D. Chen, and Z. Chang CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation J. Cell Biol. 181 2008 959 972
15. Y. Wang, F. Ren, Y. Feng, D. Wang, B. Jia, Y. Qiu, S. Wang, J. Yu, J.J. Sung, J. Xu, N. Zeps, and Z. Chang CHIP/Stub1 functions as a tumor suppressor and represses NF-kappaB-mediated signaling in colorectal cancer Carcinogenesis 2013 10.1093/carcin/bgt393
16. Y. Shang, X. Zhao, B. Tian, Y. Wang, F. Ren, B. Jia, Y. Zhai, W. Chen, D. He, and Z. Chang CHIP/Stub1 interacts with eIF5A and mediates its degradation Cell. Signal. 26 2014 1098 1104
17. J.N. Min, R.A. Whaley, N.E. Sharpless, P. Lockyer, A.L. Portbury, and C. Patterson CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control Mol. Cell. Biol. 28 2008 4018 4025
18. B.S. Shan Li, Yanquan Zhang, Jia Li, Junwei Guo, Yinyin Wang, Fangli Ren, Guozhi Xiao, Zhijie Chang, and Di Chen CHIP regulates osteoclast formation through promoting TRAF6 protein degradation Arthritis Rheumatol. 2014 10.1002/art.38521
19. S.M. Soond, and A. Chantry How ubiquitination regulates the TGF-beta signalling pathway: new insights and new players: new isoforms of ubiquitin-activating enzymes in the E1-E3 families join the game BioEssays 33 2011 749 758
20. K.H. Wrighton, X. Lin, and X.H. Feng Critical regulation of TGFbeta signaling by Hsp90 Proc. Natl. Acad. Sci. USA 105 2008 9244 9249
21. C.H. Yun, S.Y. Yoon, T.T. Nguyen, H.Y. Cho, T.H. Kim, S.T. Kim, B.C. Kim, Y.S. Hong, S.J. Kim, and H.J. Lee Geldanamycin inhibits TGF-beta signaling through induction of Hsp70 Arch. Biochem. Biophys. 495 2010 8 13
22. Y. Zhou, H. Mao, S. Li, S. Cao, Z. Li, S. Zhuang, J. Fan, X. Dong, S.C. Borkan, Y. Wang, and X. Yu HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition J. Am. Soc. Nephrol. 21 2010 598 609
23. Y. Li, X. Kang, and Q. Wang HSP70 decreases receptor-dependent phosphorylation of Smad2 and blocks TGF-beta-induced epithelial-mesenchymal transition J. Genet. Genomics 38 2011 111 116
24. W.B. Pratt, Y. Morishima, H.M. Peng, and Y. Osawa Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage Exp. Biol. Med. (Maywood) 235 2010 278 289
25. B.F. Donnelly, P.G. Needham, A.C. Snyder, A. Roy, S. Khadem, J.L. Brodsky, and A.R. Subramanya Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis J. Biol. Chem. 288 2013 13124 13135
26. F. Chen, Y. Yu, J. Qian, Y. Wang, B. Cheng, C. Dimitropoulou, V. Patel, A. Chadli, R.D. Rudic, D.W. Stepp, J.D. Catravas, and D.J. Fulton Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production Arterioscler. Thromb. Vasc. Biol. 32 2012 2989 2999