메뉴 건너뛰기




Volumn 24, Issue 2, 2004, Pages 856-864

CHIP Mediates Degradation of Smad Proteins and Potentially Regulates Smad-Induced Transcription

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CHIP PROTEIN; CHIPI PROTEIN; COCHAPERONE PROTEIN; GLUTATHIONE TRANSFERASE; LIGAND; MEMBRANE RECEPTOR; PBS PROTEIN; PROTEIN; PROTEIN SERINE THREONINE KINASE; SMAD INTERACTING PROTEIN; SMAD PROTEIN; SMAD1 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; U6 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

EID: 0347986662     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.2.856-864.2004     Document Type: Article
Times cited : (108)

References (31)
  • 1
    • 0033521032 scopus 로고    scopus 로고
    • c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads
    • Akiyoshi, S., H. Inoue, J. Hanai, K. Kusanagi, N. Nemoto, K. Miyazono, and M. Kawabata. 1999. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J. Biol. Chem. 274:35269-35277.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35269-35277
    • Akiyoshi, S.1    Inoue, H.2    Hanai, J.3    Kusanagi, K.4    Nemoto, N.5    Miyazono, K.6    Kawabata, M.7
  • 2
    • 0033013126 scopus 로고    scopus 로고
    • Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
    • Ballinger, C. A., P. Connell, Y. Wu, Z. Hu, L. J. Thompson, L. Y. Yin, and C. Patterson. 1999. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol. Cell. Biol. 19:4535-4545.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4535-4545
    • Ballinger, C.A.1    Connell, P.2    Wu, Y.3    Hu, Z.4    Thompson, L.J.5    Yin, L.Y.6    Patterson, C.7
  • 3
    • 0034976149 scopus 로고    scopus 로고
    • TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
    • Bonni, S., H. R. Wang, C. G. Causing, P. Kavsak, S. L. Stroschein, K. Luo, and J. L. Wrana. 2001. TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 3:587-595.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 587-595
    • Bonni, S.1    Wang, H.R.2    Causing, C.G.3    Kavsak, P.4    Stroschein, S.L.5    Luo, K.6    Wrana, J.L.7
  • 4
    • 0037067653 scopus 로고    scopus 로고
    • E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
    • Chen, C. R., Y. Kang, P. M. Siegel, and J. Massague. 2002. E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 110:19-32.
    • (2002) Cell , vol.110 , pp. 19-32
    • Chen, C.R.1    Kang, Y.2    Siegel, P.M.3    Massague, J.4
  • 5
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-beta responses
    • Derynck, R., Y. Zhang, and X. H. Feng. 1998. Smads: transcriptional activators of TGF-beta responses. Cell 95:737-740.
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynck, R.1    Zhang, Y.2    Feng, X.H.3
  • 6
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
    • Ebisawa, T., M. Fukuchi, G. Murakami, T. Chiba, K. Tanaka, T. Imamura, and K. Miyazono. 2001. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276:12477-12480.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12477-12480
    • Ebisawa, T.1    Fukuchi, M.2    Murakami, G.3    Chiba, T.4    Tanaka, K.5    Imamura, T.6    Miyazono, K.7
  • 7
    • 0036159130 scopus 로고    scopus 로고
    • Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)
    • Feng, X. H., Y. Y. Liang, M. Liang, W. Zhai, and X. Lin. 2002. Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B). Mol. Cell 9:133-143.
    • (2002) Mol. Cell , vol.9 , pp. 133-143
    • Feng, X.H.1    Liang, Y.Y.2    Liang, M.3    Zhai, W.4    Lin, X.5
  • 8
    • 0036345454 scopus 로고    scopus 로고
    • CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
    • Imai, Y., M. Soda, S. Hatakeyama, T. Akagi, T. Hashikawa, K. I. Nakayama, and R. Takahashi. 2002. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol. Cell 10:55-67.
    • (2002) Mol. Cell , vol.10 , pp. 55-67
    • Imai, Y.1    Soda, M.2    Hatakeyama, S.3    Akagi, T.4    Hashikawa, T.5    Nakayama, K.I.6    Takahashi, R.7
  • 9
    • 0035900793 scopus 로고    scopus 로고
    • CHIP is a U-box-dependent E3 ubiquitin ligase: Identification of Hsc70 as a target for ubiquitylation
    • Jiang, J., C. A. Ballinger, Y. Wu, Q. Dai, D. M. Cyr, J. Hohfeld, and C. Patterson. 2001. CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J. Biol. Chem. 276:42938-42944.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42938-42944
    • Jiang, J.1    Ballinger, C.A.2    Wu, Y.3    Dai, Q.4    Cyr, D.M.5    Hohfeld, J.6    Patterson, C.7
  • 10
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
    • Kavsak, P., R. K. Rasmussen, C. G. Causing, S. Bonni, H. Zhu, G. H. Thomsen, and J. L. Wrana. 2000. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol. Cell 6:1365-1375.
    • (2000) Mol. Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6    Wrana, J.L.7
  • 13
    • 0034711290 scopus 로고    scopus 로고
    • Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
    • Lin, X., M. Liang, and X. H. Feng. 2000. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J. Biol. Chem. 275:36818-36822.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36818-36822
    • Lin, X.1    Liang, M.2    Feng, X.H.3
  • 14
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
    • Liu, F., C. Pouponnot, and J. Massague. 1997. Dual role of the Smad4/ DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. Genes Dev. 11:3157-3167.
    • (1997) Genes Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massague, J.3
  • 15
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-beta-activated smad2
    • Lo, R. S., and J. Massague. 1999. Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat. Cell Biol. 1:472-478.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 472-478
    • Lo, R.S.1    Massague, J.2
  • 16
    • 0033200361 scopus 로고    scopus 로고
    • The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
    • Luo, K., S. L. Stroschein, W. Wang, D. Chen, E. Martens, S. Zhou, and Q. Zhou. 1999. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev. 13:2196-2206.
    • (1999) Genes Dev. , vol.13 , pp. 2196-2206
    • Luo, K.1    Stroschein, S.L.2    Wang, W.3    Chen, D.4    Martens, E.5    Zhou, S.6    Zhou, Q.7
  • 17
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague, J. 2000. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 1:169-178.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 169-178
    • Massague, J.1
  • 18
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-beta/Smad signaling system
    • Massague, J., and D. Wotton. 2000. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J. 19:1745-1754.
    • (2000) EMBO J. , vol.19 , pp. 1745-1754
    • Massague, J.1    Wotton, D.2
  • 19
    • 0035142877 scopus 로고    scopus 로고
    • The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
    • Meacham, G. C., C. Patterson, W. Zhang, J. M. Younger, and D. M. Cyr. 2001. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat. Cell Biol. 3:100-105.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 100-105
    • Meacham, G.C.1    Patterson, C.2    Zhang, W.3    Younger, J.M.4    Cyr, D.M.5
  • 20
    • 0035694910 scopus 로고    scopus 로고
    • Smad regulation in TGF-beta signal transduction
    • Moustakas, A., S. Souchelnytskyi, and C. H. Heldin. 2001. Smad regulation in TGF-beta signal transduction. J. Cell Sci. 114:4359-4369.
    • (2001) J. Cell Sci. , vol.114 , pp. 4359-4369
    • Moustakas, A.1    Souchelnytskyi, S.2    Heldin, C.H.3
  • 21
    • 0035684430 scopus 로고    scopus 로고
    • CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein
    • Murata, S., Y. Minami, M. Minami, T. Chiba, and K. Tanaka. 2001. CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep. 2:1133-1138.
    • (2001) EMBO Rep. , vol.2 , pp. 1133-1138
    • Murata, S.1    Minami, Y.2    Minami, M.3    Chiba, T.4    Tanaka, K.5
  • 23
    • 0031773264 scopus 로고    scopus 로고
    • TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
    • Shen, X., P. P. Hu, N. T. Liberati, M. B. Datto, J. P. Frederick, and X. F. Wang. 1998. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol. Biol. Cell 9:3309-3319.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 3309-3319
    • Shen, X.1    Hu, P.P.2    Liberati, N.T.3    Datto, M.B.4    Frederick, J.P.5    Wang, X.F.6
  • 26
    • 0035292759 scopus 로고    scopus 로고
    • Themes and variations on ubiquitylation
    • Weissman, A. M. 2001. Themes and variations on ubiquitylation. Nat. Rev. Mol. Cell Biol. 2:169-178.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 169-178
    • Weissman, A.M.1
  • 27
    • 0037039327 scopus 로고    scopus 로고
    • Protein turnover: A CHIP programmed for proteolysis
    • Wiederkehr, T., B. Bukau, and A. Buchberger. 2002. Protein turnover: a CHIP programmed for proteolysis. Curr. Biol. 12:R26-R28.
    • (2002) Curr. Biol. , vol.12
    • Wiederkehr, T.1    Bukau, B.2    Buchberger, A.3
  • 28
    • 0033515620 scopus 로고    scopus 로고
    • A Smad transcriptional corepressor
    • Wotton, D., R. S. Lo, S. Lee, and J. Massague. 1999. A Smad transcriptional corepressor. Cell 97:29-39.
    • (1999) Cell , vol.97 , pp. 29-39
    • Wotton, D.1    Lo, R.S.2    Lee, S.3    Massague, J.4
  • 29
    • 0034695511 scopus 로고    scopus 로고
    • Regulation of Smad activity
    • Wrana, J. L. 2000. Regulation of Smad activity. Cell 100:189-192.
    • (2000) Cell , vol.100 , pp. 189-192
    • Wrana, J.L.1
  • 31
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu, H., P. Kavsak, S. Abdollah, J. L. Wrana, and G. H. Thomsen. 1999. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400:687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.