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Volumn 15, Issue 2, 2014, Pages 317-325

Chitosan nanoparticle encapsulated hemagglutinin-split influenza virus mucosal vaccine

Author keywords

chitosan nanoparticles; delivery systems; influenza virus; intranasal; split influenza vaccine

Indexed keywords

CHITOSAN; GAMMA INTERFERON; HEMAGGLUTININ; HEMAGGLUTININ SPLIT INFLUENZA VIRUS MUCOSAL VACCINE; INFLUENZA VACCINE; NANOPARTICLE; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG; INFLUENZA VIRUS HEMAGGLUTININ; VIRUS ANTIBODY;

EID: 84898010025     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-0058-7     Document Type: Article
Times cited : (79)

References (60)
  • 1
    • 84861801483 scopus 로고    scopus 로고
    • Clinical and socioeconomic impact of seasonal and pandemic influenza in adults and the elderly
    • 22252007 10.4161/hv.8.1.17622
    • Gasparini R, Amicizia D, Lai PL, Panatto D. Clinical and socioeconomic impact of seasonal and pandemic influenza in adults and the elderly. Hum Vaccin Immunother. 2012;8:21-8.
    • (2012) Hum Vaccin Immunother , vol.8 , pp. 21-28
    • Gasparini, R.1    Amicizia, D.2    Lai, P.L.3    Panatto, D.4
  • 2
    • 84879779375 scopus 로고    scopus 로고
    • Traditional and new influenza vaccine
    • 23824369 10.1128/CMR.00097-12
    • Wong SS, Webby RJ. Traditional and new influenza vaccine. Clin Microbiol Rev. 2013;26:476-92.
    • (2013) Clin Microbiol Rev , vol.26 , pp. 476-492
    • Wong, S.S.1    Webby, R.J.2
  • 3
    • 0017669707 scopus 로고
    • A controlled double-blind comparison of reactogenicity, immunogenicity, and protective efficacy of whole-virus and split-product influenza vaccines in children
    • 335000 10.1093/infdis/136.5.623
    • Gross PA, Ennis FA, Gaerlan PF, Denson LJ, Denning CR, Schiffman D. A controlled double-blind comparison of reactogenicity, immunogenicity, and protective efficacy of whole-virus and split-product influenza vaccines in children. J Infect Dis. 1977;136:623-32.
    • (1977) J Infect Dis , vol.136 , pp. 623-632
    • Gross, P.A.1    Ennis, F.A.2    Gaerlan, P.F.3    Denson, L.J.4    Denning, C.R.5    Schiffman, D.6
  • 4
    • 0020075961 scopus 로고
    • Clinical reactions and serologic responses after vaccination with whole-virus or split-virus influenza vaccines in children aged 6 to 36 months
    • 7070886
    • Bernstein DI, Zahradnik JM, DeAngelis CJ, Cherry JD. Clinical reactions and serologic responses after vaccination with whole-virus or split-virus influenza vaccines in children aged 6 to 36 months. Pediatrics. 1982;69:404-8.
    • (1982) Pediatrics , vol.69 , pp. 404-408
    • Bernstein, D.I.1    Zahradnik, J.M.2    Deangelis, C.J.3    Cherry, J.D.4
  • 5
    • 84877915419 scopus 로고    scopus 로고
    • Comparison of immunogenicity and reactogenicity of split versus subunit influenza vaccine in Korean children aged 6-35 months
    • 23294036 10.3109/00365548.2012.755267
    • Kim YK, Eun BW, Kim NH, Kang EK, Lee BS, Kim DH, et al. Comparison of immunogenicity and reactogenicity of split versus subunit influenza vaccine in Korean children aged 6-35 months. Scand J Infect Dis. 2013;45:460-8.
    • (2013) Scand J Infect Dis , vol.45 , pp. 460-468
    • Kim, Y.K.1    Eun, B.W.2    Kim, N.H.3    Kang, E.K.4    Lee, B.S.5    Kim, D.H.6
  • 6
    • 33749991359 scopus 로고    scopus 로고
    • The use of inactivated influenza vaccine in children
    • 17055371 10.1053/j.spid.2006.08.004
    • Wright PF. The use of inactivated influenza vaccine in children. Semin Pediatr Infect Dis. 2006;17:200-5.
    • (2006) Semin Pediatr Infect Dis , vol.17 , pp. 200-205
    • Wright, P.F.1
  • 7
    • 84866404175 scopus 로고    scopus 로고
    • Prevention and control of influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP) - United States, 2012-13 influenza season
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC). Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP) - United States, 2012-13 influenza season. Morb Mortal Wkly Rep. 2012;61:613-8.
    • (2012) Morb Mortal Wkly Rep , vol.61 , pp. 613-618
  • 8
    • 33749603340 scopus 로고    scopus 로고
    • Immunogenicity and reactogenicity of 1 versus 2 doses of trivalent inactivated influenza vaccine in vaccine-naive 5-8-year-old children
    • 16991077 10.1086/507309
    • Neuzil KM, Jackson LA, Nelson J, Kilmov A, Cox N, Bridges CB, et al. Immunogenicity and reactogenicity of 1 versus 2 doses of trivalent inactivated influenza vaccine in vaccine-naive 5-8-year-old children. J Infect Dis. 2006;194:1032-9.
    • (2006) J Infect Dis , vol.194 , pp. 1032-1039
    • Neuzil, K.M.1    Jackson, L.A.2    Nelson, J.3    Kilmov, A.4    Cox, N.5    Bridges, C.B.6
  • 9
    • 0035897889 scopus 로고    scopus 로고
    • Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/duck/Singapore/97 (H5N3) vaccine: A randomized trial of two potential vaccines against H5N1 influenza
    • 11425416 10.1016/S0140-6736(00)05066-2
    • Nicholson KG, Colegate AE, Podda A, Stephenson I, Wood J, Ypma E, et al. Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/duck/Singapore/97 (H5N3) vaccine: a randomized trial of two potential vaccines against H5N1 influenza. Lancet. 2001;357:1937-43.
    • (2001) Lancet , vol.357 , pp. 1937-1943
    • Nicholson, K.G.1    Colegate, A.E.2    Podda, A.3    Stephenson, I.4    Wood, J.5    Ypma, E.6
  • 10
    • 67651115689 scopus 로고    scopus 로고
    • Enhanced immunogenicity of seasonal influenza vaccines in young children using MF59 adjuvant
    • 19561422 10.1097/INF.0b013e31819d6394
    • Vesikari T, Pellegrini M, Karvonen A, Groth N, Borkowski A,Hagan DT, et al. Enhanced immunogenicity of seasonal influenza vaccines in young children using MF59 adjuvant. Pediatr Infect Dis J. 2009;28:563-71.
    • (2009) Pediatr Infect Dis J , vol.28 , pp. 563-571
    • Vesikari, T.1    Pellegrini, M.2    Karvonen, A.3    Groth, N.4    Borkowski, A.5    Ohagan, D.T.6
  • 11
    • 79952704589 scopus 로고    scopus 로고
    • Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes
    • 21215831 10.1016/j.vaccine.2010.12.090
    • Calabro S, Tortoli M, Baudner BC, Pacitto A, Cortese M,Hagan DT, et al. Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. Vaccine. 2011;29:1812-23.
    • (2011) Vaccine , vol.29 , pp. 1812-1823
    • Calabro, S.1    Tortoli, M.2    Baudner, B.C.3    Pacitto, A.4    Cortese, M.5    Ohagan, D.T.6
  • 12
    • 77549088441 scopus 로고    scopus 로고
    • Vaccination, squalene and anti-squalene antibodies: Facts or fiction?
    • 20206873 10.1016/j.ejim.2009.12.001
    • Lippi G, Targher G, Franchinni M. Vaccination, squalene and anti-squalene antibodies: facts or fiction? Eur J Intern Med. 2010;21:70-3.
    • (2010) Eur J Intern Med , vol.21 , pp. 70-73
    • Lippi, G.1    Targher, G.2    Franchinni, M.3
  • 13
    • 84855794966 scopus 로고    scopus 로고
    • Oily adjuvants and autoimmunity: Now time for reconsideration?
    • 22235056 10.1177/0961203311429818
    • Whitehouse M. Oily adjuvants and autoimmunity: now time for reconsideration? Lupus. 2012;21:217-22.
    • (2012) Lupus , vol.21 , pp. 217-222
    • Whitehouse, M.1
  • 14
    • 55849111880 scopus 로고    scopus 로고
    • Human muscle cells express the costimulatory molecule B7-H3, which modulated muscle-immune interactions
    • 18975328 10.1002/art.23997
    • Waschbisch A, Wintterle S, Lochmüller H, Walter MC, Wischhusen J, Kieseier BC. Human muscle cells express the costimulatory molecule B7-H3, which modulated muscle-immune interactions. Arthritis Rheum. 2008;58:3600-8.
    • (2008) Arthritis Rheum , vol.58 , pp. 3600-3608
    • Waschbisch, A.1    Wintterle, S.2    Lochmüller, H.3    Walter, M.C.4    Wischhusen, J.5    Kieseier, B.C.6
  • 15
    • 0035940309 scopus 로고    scopus 로고
    • Nasal vaccines
    • 11516777 10.1016/S0169-409X(01)00162-4
    • Davis SS. Nasal vaccines. Adv Drug Deliv Rev. 2001;51:21-42.
    • (2001) Adv Drug Deliv Rev , vol.51 , pp. 21-42
    • Davis, S.S.1
  • 16
    • 4544258068 scopus 로고    scopus 로고
    • NALT- versus Peyer's-patch-mediated mucosal immunity
    • 15343369 10.1038/nri1439
    • Kiyono H, Fukuyama S. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol. 2004;4:699-710.
    • (2004) Nat Rev Immunol , vol.4 , pp. 699-710
    • Kiyono, H.1    Fukuyama, S.2
  • 17
    • 33644836224 scopus 로고    scopus 로고
    • Mucosal vaccines: The promise and the challenge
    • 16491139 10.1038/nri1777
    • Neutra MR, Kozlowski PA. Mucosal vaccines: the promise and the challenge. Nat Rev Immunol. 2006;6:148-58.
    • (2006) Nat Rev Immunol , vol.6 , pp. 148-158
    • Neutra, M.R.1    Kozlowski, P.A.2
  • 18
    • 84857051772 scopus 로고    scopus 로고
    • The mucosal and systemic immune responses elicited by a chitosan-adjuvanted intranasal influenza H5N1 vaccine
    • 10.1111/j.1750-2659.2011.00271.x
    • Svindland SC, Jul-Larsen Å, Pathirana R, Anderson S, Madhun A, Montomoli E, et al. The mucosal and systemic immune responses elicited by a chitosan-adjuvanted intranasal influenza H5N1 vaccine. Influenza Other Respi Viruses. 2011;6:90-100.
    • (2011) Influenza Other Respi Viruses , vol.6 , pp. 90-100
    • Svindland, S.C.1    Jul-Larsen, Å.2    Pathirana, R.3    Anderson, S.4    Madhun, A.5    Montomoli, E.6
  • 19
    • 33845201992 scopus 로고    scopus 로고
    • N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: Biological properties and immunogenicity in a mouse model
    • 16973248 10.1016/j.vaccine.2006.06.086
    • Amidi M, Romeijn SG, Verhoef JC, Junginger HE, Bungener L, Huckriede A, et al. N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model. Vaccine. 2007;25:144-53.
    • (2007) Vaccine , vol.25 , pp. 144-153
    • Amidi, M.1    Romeijn, S.G.2    Verhoef, J.C.3    Junginger, H.E.4    Bungener, L.5    Huckriede, A.6
  • 20
    • 84855418341 scopus 로고    scopus 로고
    • Chitosan microparticles and nanoparticles as biocompatible delivery vehicles for peptide and protein-based immunocontraceptive vaccines
    • 22149016 10.1021/mp200264m
    • Chua BY, Al Kobaisi M, Zeng W, Mainwaring D, Jackson DC. Chitosan microparticles and nanoparticles as biocompatible delivery vehicles for peptide and protein-based immunocontraceptive vaccines. Mol Pharm. 2012;9:81-90.
    • (2012) Mol Pharm , vol.9 , pp. 81-90
    • Chua, B.Y.1    Al Kobaisi, M.2    Zeng, W.3    Mainwaring, D.4    Jackson, D.C.5
  • 21
    • 67349275606 scopus 로고    scopus 로고
    • Low molecular weight chitosan in DNA vaccine delivery via mucosa
    • 19481698 10.1016/j.ijpharm.2009.03.032
    • Yang X, Yuan X, Cai D, Wang S, Zong L. Low molecular weight chitosan in DNA vaccine delivery via mucosa. Int J Pharm. 2009;375:123-32.
    • (2009) Int J Pharm , vol.375 , pp. 123-132
    • Yang, X.1    Yuan, X.2    Cai, D.3    Wang, S.4    Zong, L.5
  • 23
    • 9244265493 scopus 로고    scopus 로고
    • Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery
    • 15560949 10.1016/j.addr.2004.09.004
    • Alpar HO, Somavarapu S, Atuah KN, Bramwell VW. Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery. Adv Drug Deliv Rev. 2005;57:411-30.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 411-430
    • Alpar, H.O.1    Somavarapu, S.2    Atuah, K.N.3    Bramwell, V.W.4
  • 24
    • 78249285928 scopus 로고    scopus 로고
    • Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant
    • 20870054 10.1016/j.vaccine.2010.09.019
    • Sui Z, Chen Q, Fang F, Zheng M, Chen Z. Cross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvant. Vaccine. 2010;28:7690-8.
    • (2010) Vaccine , vol.28 , pp. 7690-7698
    • Sui, Z.1    Chen, Q.2    Fang, F.3    Zheng, M.4    Chen, Z.5
  • 26
    • 84863552260 scopus 로고    scopus 로고
    • Intranasal immunization with a formalin-inactivated human influenza A virus whole-virion vaccine alone and intranasal immunization with split-virion vaccine with mucosal adjuvants show similar levels of cross-protection
    • 3393367 22552600 10.1128/CVI.00016-12
    • Okamoto S, Matsuoka S, Takenaka N, Haredy AM, Tanimoto T, Gomi Y, et al. Intranasal immunization with a formalin-inactivated human influenza A virus whole-virion vaccine alone and intranasal immunization with split-virion vaccine with mucosal adjuvants show similar levels of cross-protection. Clin Vaccine Immunol. 2012;19:979-90.
    • (2012) Clin Vaccine Immunol , vol.19 , pp. 979-990
    • Okamoto, S.1    Matsuoka, S.2    Takenaka, N.3    Haredy, A.M.4    Tanimoto, T.5    Gomi, Y.6
  • 27
    • 0031550212 scopus 로고    scopus 로고
    • Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
    • 10.1002/(SICI)1097-4628(19970103)63:1<125: AID-APP13>3.0.CO;2-4
    • Calvo P, Remuñán-López C, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci. 1997;63:125-32.
    • (1997) J Appl Polym Sci , vol.63 , pp. 125-132
    • Calvo, P.1    Remuñán-López, C.2    Vila-Jato, J.L.3    Alonso, M.J.4
  • 28
    • 69749106545 scopus 로고    scopus 로고
    • Poly(γ-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice
    • 19647814 10.1016/j.vaccine.2009.07.037
    • Okamoto S, Matsuura M, Akagi T, Akashi M, Tanimoto T, Ishikawa T, et al. Poly(γ-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice. Vaccine. 2009;27:5896-905.
    • (2009) Vaccine , vol.27 , pp. 5896-5905
    • Okamoto, S.1    Matsuura, M.2    Akagi, T.3    Akashi, M.4    Tanimoto, T.5    Ishikawa, T.6
  • 29
    • 36049012225 scopus 로고    scopus 로고
    • Influenza hemagglutinin vaccine with poly(γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity
    • 17977633 10.1016/j.vaccine.2007.09.051
    • Okamoto S, Yoshii H, Akagi T, Akashi M, Ishikawa T, Okuno Y, et al. Influenza hemagglutinin vaccine with poly(γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity. Vaccine. 2007;25:8270-8.
    • (2007) Vaccine , vol.25 , pp. 8270-8278
    • Okamoto, S.1    Yoshii, H.2    Akagi, T.3    Akashi, M.4    Ishikawa, T.5    Okuno, Y.6
  • 30
    • 0037402224 scopus 로고    scopus 로고
    • The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccine
    • 12686092 10.1016/S0264-410X(03)00070-7
    • Nichol KL. The efficacy, effectiveness and cost-effectiveness of inactivated influenza virus vaccine. Vaccine. 2003;21:1769-75.
    • (2003) Vaccine , vol.21 , pp. 1769-1775
    • Nichol, K.L.1
  • 31
    • 84883659521 scopus 로고    scopus 로고
    • Antibodies and their receptors: Different potential roles in mucosal defense
    • 3712224 23882268 10.3389/fimmu.2013.00200
    • Horton RE, Vidarsson G. Antibodies and their receptors: different potential roles in mucosal defense. Front Immunol. 2013;4:200.
    • (2013) Front Immunol , vol.4 , pp. 200
    • Horton, R.E.1    Vidarsson, G.2
  • 32
    • 15044347334 scopus 로고    scopus 로고
    • Role of IgA in the defense against respiratory infections IgA deficient mice exhibited increased susceptibility to intranasal infection with Mycobacterium bovis BCG
    • 10.1016/j.vaccine.2004.11.032
    • Rodríquez A, Tjärnlund A, Ivanji J, Singh M, García I, Williams A, et al. Role of IgA in the defense against respiratory infections IgA deficient mice exhibited increased susceptibility to intranasal infection with Mycobacterium bovis BCG. Vaccine. 2005;23:2565-72.
    • (2005) Vaccine , vol.23 , pp. 2565-2572
    • Rodríquez, A.1    Tjärnlund, A.2    Ivanji, J.3    Singh, M.4    García, I.5    Williams, A.6
  • 33
    • 67349144253 scopus 로고    scopus 로고
    • Physicochemical and immunological characterization of N, N, N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration
    • 19224344 10.1007/s11095-009-9845-y
    • Hagenaars N, Mastrobattista E, Verheul RJ, Mooren I, Glansbeek HL, Heldens JG, et al. Physicochemical and immunological characterization of N, N, N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration. Pharm Res. 2009;26:1353-64.
    • (2009) Pharm Res , vol.26 , pp. 1353-1364
    • Hagenaars, N.1    Mastrobattista, E.2    Verheul, R.J.3    Mooren, I.4    Glansbeek, H.L.5    Heldens, J.G.6
  • 34
    • 84871284434 scopus 로고    scopus 로고
    • Enhancement of the immunogenicity and protective efficacy of a mucosal influenza subunit vaccine by the saponin adjuvant GPI-0100
    • 10.1371/journal.pone.0052135 3524133 23284901 10.1371/journal.pone. 0052135
    • Liu H, Patil HP, de Vries-Idema J, Wilschut J, Huckriede A. Enhancement of the immunogenicity and protective efficacy of a mucosal influenza subunit vaccine by the saponin adjuvant GPI-0100. PLoS One. 2012;7:e52135. doi: 10.1371/journal.pone.0052135.
    • (2012) PLoS One , vol.7 , pp. 52135
    • Liu, H.1    Patil, H.P.2    De Vries-Idema, J.3    Wilschut, J.4    Huckriede, A.5
  • 35
    • 62849109927 scopus 로고    scopus 로고
    • Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems
    • 18661544 10.1002/jps.21493
    • Sharma S, Mukkur TK, Benson HA, Chen Y. Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems. J Pharm Sci. 2009;98:812-43.
    • (2009) J Pharm Sci , vol.98 , pp. 812-843
    • Sharma, S.1    Mukkur, T.K.2    Benson, H.A.3    Chen, Y.4
  • 36
    • 84864492941 scopus 로고    scopus 로고
    • Intranasal immunization with live attenuated influenza vaccine plus chitosan as an adjuvant protects mice against homologous and heterologous virus challenge
    • 22552485 10.1007/s00705-012-1318-7
    • Wang X, Zhang W, Liu F, Zheng M, Zheng D, Zhang T, et al. Intranasal immunization with live attenuated influenza vaccine plus chitosan as an adjuvant protects mice against homologous and heterologous virus challenge. Arch Virol. 2012;157:1451-61.
    • (2012) Arch Virol , vol.157 , pp. 1451-1461
    • Wang, X.1    Zhang, W.2    Liu, F.3    Zheng, M.4    Zheng, D.5    Zhang, T.6
  • 37
    • 84859328852 scopus 로고    scopus 로고
    • Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein
    • 3322645 22356166 10.1021/mp200553x
    • Raghuwanshi D, Mishra V, Das D, Kaur K, Suresh MR. Dendritic cell targeted chitosan nanoparticles for nasal DNA immunization against SARS CoV nucleocapsid protein. Mol Pharm. 2012;9:946-56.
    • (2012) Mol Pharm , vol.9 , pp. 946-956
    • Raghuwanshi, D.1    Mishra, V.2    Das, D.3    Kaur, K.4    Suresh, M.R.5
  • 38
    • 84867024503 scopus 로고    scopus 로고
    • Intranasal immunization of mice against Streptococcus equi using positively charged nanoparticulate carrier systems
    • 22947139 10.1016/j.vaccine.2012.08.050
    • Figueiredo L, Cadete A, Gonçalves LM, Corvo ML, Almeida AJ. Intranasal immunization of mice against Streptococcus equi using positively charged nanoparticulate carrier systems. Vaccine. 2012;30:6551-8.
    • (2012) Vaccine , vol.30 , pp. 6551-6558
    • Figueiredo, L.1    Cadete, A.2    Gonçalves, L.M.3    Corvo, M.L.4    Almeida, A.J.5
  • 39
    • 75149183537 scopus 로고    scopus 로고
    • Chitosan-based delivery systems for protein therapeutics and antigens
    • 19925837 10.1016/j.addr.2009.11.009
    • Amidi M, Mastrobattista E, Jiskoot W, Hennick WE. Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev. 2010;62:59-82.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 59-82
    • Amidi, M.1    Mastrobattista, E.2    Jiskoot, W.3    Hennick, W.E.4
  • 40
    • 70350208807 scopus 로고    scopus 로고
    • Ionically cross-linked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery
    • 19660537 10.1016/j.ijpharm.2009.07.028
    • Csaba N, Köping-Höggård M, Alonso MJ. Ionically cross-linked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery. Int J Pharm. 2009;382:205-14.
    • (2009) Int J Pharm , vol.382 , pp. 205-214
    • Csaba, N.1    Köping-Höggård, M.2    Alonso, M.J.3
  • 41
    • 0037413407 scopus 로고    scopus 로고
    • Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles
    • 12480287 10.1016/S0378-5173(02)00548-3
    • Xu Y, Du Y. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int J Pharm. 2003;250:215-26.
    • (2003) Int J Pharm , vol.250 , pp. 215-226
    • Xu, Y.1    Du, Y.2
  • 42
    • 23444441931 scopus 로고    scopus 로고
    • Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery
    • 16024239 10.1016/j.colsurfb.2005.06.001
    • Gan Q, Wang T, Cochrane C, McCarron P. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids Surf B Biointerfaces. 2005;44:65-73.
    • (2005) Colloids Surf B Biointerfaces , vol.44 , pp. 65-73
    • Gan, Q.1    Wang, T.2    Cochrane, C.3    McCarron, P.4
  • 43
    • 0345466363 scopus 로고    scopus 로고
    • Effect of formulation variables on cis-platin loaded chitosan microsphere properties
    • 10575622 10.1080/026520499288645
    • Akbuǧa J, Bergisadi N. Effect of formulation variables on cis-platin loaded chitosan microsphere properties. J Microencapsul. 1999;16:697-703.
    • (1999) J Microencapsul , vol.16 , pp. 697-703
    • Akbuǧa, J.1    Bergisadi, N.2
  • 44
    • 84862646294 scopus 로고    scopus 로고
    • Chitosan-based drug nanocarriers: Where do we stand?
    • 22480607 10.1016/j.jconrel.2012.03.017
    • Garcia-Fuentes M, Alonso MJ. Chitosan-based drug nanocarriers: where do we stand? J Control Release. 2012;161:496-504.
    • (2012) J Control Release , vol.161 , pp. 496-504
    • Garcia-Fuentes, M.1    Alonso, M.J.2
  • 45
    • 75149133614 scopus 로고    scopus 로고
    • Chitosan-based formulations for delivery of DNA and siRNA
    • 19796660 10.1016/j.addr.2009.08.004
    • Mao S, Sun W, Kissel T. Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev. 2010;62:12-27.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 12-27
    • Mao, S.1    Sun, W.2    Kissel, T.3
  • 46
    • 10044226252 scopus 로고    scopus 로고
    • Transmucosal macromolecule drug delivery
    • 15588901 10.1016/j.jconrel.2004.07.030
    • Prego C, García M, Torres D, Alonso MJ. Transmucosal macromolecule drug delivery. J Control Release. 2005;101:151-62.
    • (2005) J Control Release , vol.101 , pp. 151-162
    • Prego, C.1    García, M.2    Torres, D.3    Alonso, M.J.4
  • 47
    • 0346094226 scopus 로고    scopus 로고
    • Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice
    • 14729088 10.1016/j.ejpb.2003.09.006
    • Vila A, Sánchez A, Janes K, Behrens I, Kissel T, Vila Jato JL, et al. Low molecular weight chitosan nanoparticles as new carriers for nasal vaccine delivery in mice. Eur J Pharm Biopharm. 2004;57:123-31.
    • (2004) Eur J Pharm Biopharm , vol.57 , pp. 123-131
    • Vila, A.1    Sánchez, A.2    Janes, K.3    Behrens, I.4    Kissel, T.5    Vila Jato, J.L.6
  • 48
    • 0037459005 scopus 로고    scopus 로고
    • Nasal drug delivery - Possibilities, problems and solutions
    • 12618035 10.1016/S0168-3659(02)00363-2
    • Illum L. Nasal drug delivery - possibilities, problems and solutions. J Control Release. 2003;87:187-98.
    • (2003) J Control Release , vol.87 , pp. 187-198
    • Illum, L.1
  • 49
    • 21344448185 scopus 로고    scopus 로고
    • Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model
    • 10.1016/j.ijpharm.2005.03.035
    • Forged C, Brodin B, Frokjaer S, Sundblad A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm. 2005;298:315-22.
    • (2005) Int J Pharm , vol.298 , pp. 315-322
    • Forged, C.1    Brodin, B.2    Frokjaer, S.3    Sundblad, A.4
  • 50
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • 16198441 10.1016/j.addr.2005.07.001
    • Smart JD. The basics and underlying mechanisms of mucoadhesion. Adv Drug Deliv Rev. 2005;57:1556-68.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1556-1568
    • Smart, J.D.1
  • 51
    • 33645228369 scopus 로고    scopus 로고
    • The use of soluble polymers and polymer microparticles to provide improved vaccine responses after parenteral and mucosal delivery
    • Davis SS. The use of soluble polymers and polymer microparticles to provide improved vaccine responses after parenteral and mucosal delivery. Vaccine. 2006;24(2):S2-7-10.
    • (2006) Vaccine , vol.24 , Issue.2 , pp. 2-710
    • Davis, S.S.1
  • 53
    • 0017126775 scopus 로고
    • Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay
    • 1083422 10.1084/jem.143.5.1283
    • Bevan MJ. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med. 1976;143:1283-8.
    • (1976) J Exp Med , vol.143 , pp. 1283-1288
    • Bevan, M.J.1
  • 54
    • 84871609642 scopus 로고    scopus 로고
    • Vaccine delivery carriers: Insights and future perspectives
    • 22561794 10.1016/j.ijpharm.2012.04.047
    • Correia-Pinto JF, Csaba N, Alonso MJ. Vaccine delivery carriers: insights and future perspectives. Int J Pharm. 2013;440:27-38.
    • (2013) Int J Pharm , vol.440 , pp. 27-38
    • Correia-Pinto, J.F.1    Csaba, N.2    Alonso, M.J.3
  • 55
    • 77249104877 scopus 로고    scopus 로고
    • Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    • 20138662 10.1016/j.biomaterials.2010.01.065
    • He C, Hu Y, Yin L, Tang C, Yin C. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials. 2010;31:3657-66.
    • (2010) Biomaterials , vol.31 , pp. 3657-3666
    • He, C.1    Hu, Y.2    Yin, L.3    Tang, C.4    Yin, C.5
  • 56
    • 1842555353 scopus 로고    scopus 로고
    • Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery
    • 15139524 10.1023/B:PHAM.0000022414.17183.58
    • Nagamoto T, Hattori Y, Takayama K, Maitani Y. Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery. Pharm Res. 2004;21:671-4.
    • (2004) Pharm Res , vol.21 , pp. 671-674
    • Nagamoto, T.1    Hattori, Y.2    Takayama, K.3    Maitani, Y.4
  • 57
    • 0028357118 scopus 로고
    • Mucoadhesion of latexes. II. Adsorption isotherms and desorption studies
    • 10.1023/A:1018920128007
    • Durrey C, Irache JM, Puisieux F, Duchêne D, Ponchel G. Mucoadhesion of latexes. II. Adsorption isotherms and desorption studies. Pharm Res. 1994;11:680-3.
    • (1994) Pharm Res , vol.11 , pp. 680-683
    • Durrey, C.1    Irache, J.M.2    Puisieux, F.3    Duchêne, D.4    Ponchel, G.5
  • 59
    • 34250685691 scopus 로고    scopus 로고
    • Should a new tuberculosis vaccine be administered intranasally?
    • 17321797 10.1016/j.tube.2006.12.006
    • Källenius G, Pawlowski A, Brandtzaeg P, Svenson S. Should a new tuberculosis vaccine be administered intranasally? Tuberculosis. 2007;87:257-66.
    • (2007) Tuberculosis , vol.87 , pp. 257-266
    • Källenius, G.1    Pawlowski, A.2    Brandtzaeg, P.3    Svenson, S.4
  • 60
    • 17144431433 scopus 로고    scopus 로고
    • Nanoparticles as carriers for nasal vaccine delivery
    • 15889992 10.1586/14760584.4.2.185
    • Köping-Höggård M, Sánchez A, Alonso MJ. Nanoparticles as carriers for nasal vaccine delivery. Expert Rev Vaccines. 2005;4:185-96.
    • (2005) Expert Rev Vaccines , vol.4 , pp. 185-196
    • Köping-Höggård, M.1    Sánchez, A.2    Alonso, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.