Development of zwitterionic polymer-based doxorubicin conjugates: Tuning the surface charge to prolong the circulation and reduce toxicity

Langmuir

Volumn 30, Issue 13, 2014, Pages 3764-3774

  Wang, Zhen ^a   Ma, Guanglong ^a   Zhang, Juan ^a   Lin, Weifeng ^a   Ji, Fangqin ^a   Bernards, Matthew T ^b   Chen, Shengfu ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL RESISTANCE; CONJUGATED POLYMERS; FUNCTIONAL GROUPS; POLYETHYLENE GLYCOLS; TOXICITY; TUMORS;

DOXORUBICIN CONJUGATES; NEGATIVE SURFACE CHARGES; NEGATIVELY CHARGED; NON-SPECIFIC PROTEIN ADSORPTION; PROTEIN ADSORPTION; SYSTEMIC TOXICITIES; WATERSOLUBLE POLYMERS; ZWITTERIONIC POLYMERS;

POLYMERS;

ANTINEOPLASTIC AGENT; BETAINE; DOXORUBICIN; DRUG CARRIER; MACROGOL DERIVATIVE; POLYCARBOXYBETAINE METHACRYLATE; POLYMETHACRYLIC ACID DERIVATIVE;

ADSORPTION; ANIMAL; CELL SURVIVAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; DRUG SCREENING; FEMALE; INSTITUTE FOR CANCER RESEARCH MOUSE; MAMMARY NEOPLASMS, EXPERIMENTAL; MOUSE; NUDE MOUSE; PATHOLOGY; STATIC ELECTRICITY; SYNTHESIS; TUMOR CELL LINE; TUMOR VOLUME;

ADSORPTION; ANIMALS; ANTINEOPLASTIC AGENTS; BETAINE; CELL LINE, TUMOR; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DOXORUBICIN; DRUG CARRIERS; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED ICR; MICE, NUDE; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; STATIC ELECTRICITY; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898005984     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/la5000765     Document Type: Article

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