Hepatitis C virus represses E-cadherin expression via DNA methylation to induce epithelial to mesenchymal transition in human hepatocytes

Biochemical and Biophysical Research Communications

Volumn 446, Issue 2, 2014, Pages 561-567

  Park, Jungmi ^a   Jang, Kyung Lib ^a  

^a Pusan National University   (South Korea)

Author keywords

DNA methylation; E cadherin; Epithelial mesenchymal transition; Hepatitis C virus

Indexed keywords

COMPLEMENTARY DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3B; TRANSCRIPTION FACTOR SP1; UVOMORULIN;

ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE REPRESSION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPLICON;

HEPATITIS C VIRUS;

DNA METHYLATION; E-CADHERIN; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATITIS C VIRUS;

CADHERINS; CELL LINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; HEPACIVIRUS; HEPATOCYTES; HUMANS;

EID: 84897977944     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.03.009     Document Type: Article

References (34)

1. M.A. Feitelson Parallel epigenetic and genetic changes in the pathogenesis of hepatitis virus-associated hepatocellular carcinoma Cancer Lett. 239 2006 10 20
2. N. Nishida, T. Nagasaka, T. Nishimura, I. Ikai, C.R. Boland, and A. Goel Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma Hepatology 47 2008 908 918
3. W.H. Caselmann, and M. Alt Hepatitis C virus infection as a major risk factor for hepatocellular carcinoma J. Hepatol. 24 1996 61 66
4. B. Yang, M. Guo, J.G. Herman, and D.P. Clark Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma Am. J. Pathol. 163 2003 1101 1107
5. Q. Feng, J.E. Stern, S.E. Hawes, H. Lu, M. Jiang, and N.B. Kiviat DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection Exp. Mol. Pathol. 88 2010 287 292
6. M. Ripoli, R. Barbano, T. Balsamo, C. Piccoli, V. Brunetti, M. Coco, G. Mazzoccoli, M. Vinciguerra, and V. Pazienza Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein Virus Res. 160 2011 74 81
7. P. Arora, E.O. Kim, J.K. Jung, and K.L. Jang Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b Cancer Lett. 261 2008 244 252
8. S.H. Park, J.S. Lim, S.Y. Lim, I. Tiwari, and K.L. Jang Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation Cancer Lett. 310 2011 61 68
9. T. Kato, T. Date, M. Miyamoto, A. Furusaka, K. Tokushige, M. Mizokami, and T. Wakita Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon Gastroenterology 125 2003 1808 1817
10. J. Zhong, P. Gastaminza, G. Cheng, S. Kapadia, T. Kato, D.R. Burton, S.F. Wieland, S.L. Uprichard, T. Wakita, and F.V. Chisari Robust hepatitis C virus infection in vitro Proc. Natl. Acad. Sci. USA 102 2005 9294 9299
11. T. Takeuchi, A. Katsume, T. Tanaka, A. Abe, K. Inoue, K. Tsukiyama-Kohara, R. Kawaguchi, S. Tanaka, and M. Kohara Real-time detection system for quantification of hepatitis C virus genome Gastroenterology 116 1999 636 642
12. J.K. Jung, P. Arora, J.S. Pagano, and K.L. Jang Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway Cancer Res. 67 2007 5771 5778
13. J.O. Lee, H.J. Kwun, J.K. Jung, K.H. Choi, D.S. Min, and K.L. Jang Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1 Oncogene 24 2005 6617 6625
14. A.H. Ting, K.W. Jair, H. Suzuki, R.W. Yen, S.B. Baylin, and K.E. Schuebel CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1 Nat. Genet. 36 2004 582 584
15. S. Bai, K. Ghoshal, J. Datta, S. Majumder, S.O. Yoon, and S.T. Jacob DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2 Mol. Cell. Biol. 25 2005 751 766
16. J.G. Herman, J.R. Graff, S. Myohanen, B.D. Nelkin, and S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc. Natl. Acad. Sci. USA 93 1996 9821 9826
17. Y.J. Woo, and K.L. Jang All-trans retinoic acid activates E-cadherin expression via promoter hypomethylation in the human colon carcinoma HCT116 cells Biochem. Biophys. Res. Commun. 425 2012 944 949
18. Y. Lin, Y. Wu, J. Li, C. Dong, X. Ye, Y.I. Chi, B.M. Evers, and B.P. Zhou The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1 EMBO J. 29 2010 1803 1816
19. J. Kawanishi, J. Kato, K. Sasaki, S. Fujii, N. Watanabe, and Y. Niitsu Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39 Mol. Cell. Biol. 15 1995 1175 1181
20. L.G. Rodriguez, X. Wu, and J.L. Guan Wound-healing assay Methods Mol. Biol. 294 2005 23 29
21. R. Sumpter Jr., Y.M. Loo, E. Foy, K. Li, M. Yoneyama, T. Fujita, S.M. Lemon, and M. Gale Jr. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I J. Virol. 79 2005 2689 2699
22. K.J. Blight, J.A. McKeating, and C.M. Rice Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication J. Virol. 76 2002 13001 13014
23. A. Erhardt, M. Hassan, T. Heintges, and D. Haussinger Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line Virology 292 2002 272 284
24. P. Bigey, S. Ramchandani, J. Theberge, F.D. Araujo, and M. Szyf Transcriptional regulation of the human DNA methyltransferase (dnmt1) gene Gene 242 2000 407 418
25. J.C. Wu, and D.V. Santi On the mechanism and inhibition of DNA cytosine methyltransferases Prog. Clin. Biol. Res. 198 1985 119 129
26. T.H. Bestor The DNA methyltransferases of mammals Hum. Mol. Genet. 9 2000 2395 2402
27. H.J. Park, E. Yu, and Y.H. Shim DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma Cancer Lett. 233 2006 271 278
28. M. Takeichi Morphogenetic roles of classic cadherins Curr. Opin. Cell Biol. 7 1995 619 627
29. F. van Roy, and G. Berx The cell-cell adhesion molecule E-cadherin Cell. Mol. Life Sci. 65 2008 3756 3788
30. S. Hirohashi, and Y. Kanai Cell adhesion system and human cancer morphogenesis Cancer Sci. 94 2003 575 581
31. Y. Kanai, S. Ushijima, A.M. Hui, A. Ochiai, H. Tsuda, M. Sakamoto, and S. Hirohashi The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas Int. J. Cancer 71 1997 355 359
32. M. Watabe, A. Nagafuchi, S. Tsukita, and M. Takeichi Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line J. Cell Biol. 127 1994 247 256
33. A. Buda, and M. Pignatelli E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis Cell. Commun. Adhes. 18 2011 133 143
34. C. Palena, R.I. Fernando, M.T. Litzinger, D.H. Hamilton, B. Huang, and J. Schlom Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells Exp. Biol. Med. (Maywood) 236 2011 537 545