GABA and topiramate inhibit the formation of human macrophage-derived foam cells by modulating cholesterol-metabolism-associated molecules

Cellular Physiology and Biochemistry

Volumn 33, Issue 4, 2014, Pages 1117-1129

  Yang, Ying ^a,b   Lian, Yi Tian ^a   Huang, Shi Yuan ^a   Yang, Yong ^a   Cheng, Long Xian ^a   Liu, Kun ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b AFFILIATED HOSPITAL OF NORTH SICHUAN MEDICAL COLLEGE   (China)

Author keywords

Atherosclerosis; Cholesterol; GABA; GABA receptor agonist; Macrophage

Indexed keywords

4 AMINOBUTYRIC ACID; ABC TRANSPORTER A1; ABC TRANSPORTER G1; BACLOFEN; CD36 ANTIGEN; CHOLESTEROL; CHOLESTEROL ESTER; FAT DROPLET; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; SCAVENGER RECEPTOR A; SCAVENGER RECEPTOR BI; TOPIRAMATE; TUMOR NECROSIS FACTOR ALPHA; ABC TRANSPORTER; ABCG1 PROTEIN, HUMAN; FRUCTOSE; LOW DENSITY LIPOPROTEIN; NEUROPROTECTIVE AGENT; OLR1 PROTEIN, HUMAN; APOLIPOPROTEIN A1; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE 1; HIGH DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL PHAGOCYTOSIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENSITY GRADIENT CENTRIFUGATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FOAM CELL; GEL MOBILITY SHIFT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN EXPERIMENT; IMMUNOMODULATION; INFLAMMATION; MACROPHAGE; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION INHIBITION; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAINING; UPREGULATION; VOLUNTEER; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; CHOLESTEROL TRANSPORT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; MACROPHAGE DERIVED FOAM CELL; REAL TIME POLYMERASE CHAIN REACTION;

ANTIGENS, CD36; ATP BINDING CASSETTE TRANSPORTER 1; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL; DOWN-REGULATION; FOAM CELLS; FRUCTOSE; GAMMA-AMINOBUTYRIC ACID; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SCAVENGER RECEPTORS, CLASS A; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84897966584     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000358681     Document Type: Article

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