RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric cancer cells

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 4, 2014, Pages 610-623

  Liu, Zhifang ^a   Chen, Long ^a   Zhang, Xinchao ^a   Xu, Xia ^a   Xing, Huaixin ^b   Zhang, Yingjie ^b   Li, Wenjuan ^a   Yu, Han ^a   Zeng, Jiping ^a   Jia, Jihui ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Epithelial mesenchymal transition; Gastric cancer; MiR 30a; Runt related transcription factor 3; Vimentin

Indexed keywords

MICRORNA; MIRN30 MICRORNA, HUMAN; RUNX3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RUNX3; VIMENTIN;

ANIMAL; BIOSYNTHESIS; DRUG SCREENING; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; METASTASIS; MOUSE; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 3 SUBUNIT; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; STOMACH NEOPLASMS; VIMENTIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84897960280     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12209     Document Type: Article

References (42)

1. Vogiatzi P, Vindigni C, Roviello F, et al. Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis. J Cell Physiol. 2007; 211: 287-95.
2. DiMario F, Cavallaro LG, Cavestro GM, et al. Are there useful biomarkers for gastric cancer? Dig Liver Dis. 2006; 38: 308-09.
3. Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009; 9: 274-84.
4. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer. 2003; 3: 453-458.
5. Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science. 2011; 331: 1559-64.
6. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007; 7: 415-28.
7. Liu Z, Li Q, Li K, et al. Telomerase reverse transcriptase promotes epithelial- mesenchymal transition and stem cell-like traits in cancer cells. Oncogene. 2013; 32: 4203-13.
8. Zhao X, Dou W, He L, et al. MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene. 2013; 32: 1363-72.
9. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002; 2: 442-54.
10. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006; 7: 131-42.
11. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119: 1420-28.
12. Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer. 2009; 9: 265-73.
13. Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139: 871-90.
14. Tsuji T, Ibaragi S, Hu GF. Epithelial-mesenchymal transition and cell cooperativity in metastasis. Cancer Res. 2009; 69: 7135-39.
15. Van ZF, Zulehner G, Petz M, et al. Epithelial-mesenchymal transition in hepatocellular carcinoma. Future Oncol. 2009; 5: 1169-79.
16. Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009; 119: 1429-37.
17. Kania MA, Bonner AS, Duffy JB, et al. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev. 1990; 4: 1701-13.
18. Daga A, Karlovich CA, Dumstrei K, et al. Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1. Genes Dev. 1996; 10: 1194-1205.
19. Ito Y. Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF. Genes Cells. 1999; 4: 685-696.
20. Lin FC, Liu YP, Lai CH, et al. RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells. Oncogene. 2012; 31: 4302-16.
21. Levanon D, Negreanu V, Bernstein Y, et al. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Genomics. 1994; 23: 425-32.
22. Otto F, Lubbert M, Stock M. Upstream and downstream targets of RUNX proteins. J Cell Biochem. 2003; 89: 9-18.
23. Ito Y. Oncogenic potential of the RUNX gene family: 'overview'. Oncogene. 2004; 23: 4198-4208.
24. Li QL, Ito K, Sakakura C, et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell. 2002; 109: 113-24.
25. Ito K. RUNX3 in oncogenic and anti-oncogenic signaling in gastrointestinal cancers. J Cell Biochem. 2011; 112: 1243-9.
26. Chi XZ, Yang JO, Lee KY, et al. RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Mol Cell Biol. 2005; 25: 8097-107.
27. Yano T, Ito K, Fukamachi H, et al. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol. 2006; 26: 4474-88.
28. Ito K, Chuang LS, Ito T, et al. Loss of Runx3 is a key event in inducing precancerous state of the stomach. Gastroenterology. 2011; 140: 1536-46.
29. Sakakura C, Hasegawa K, Miyagawa K, et al. Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers. Clin Cancer Res. 2005; 11: 6479-88.
30. Peng Z, Wei D, Wang L, et al. RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. Clin Cancer Res. 2006; 12: 6386-94.
31. Chang TL, Ito K, Ko TK, et al. Claudin-1 has tumor suppressive activity and is a direct target of RUNX3 in gastric epithelial cells. Gastroenterology. 2010; 138: 255-65.
32. Chen Y, Wei X, Guo C, et al. Runx3 suppresses gastric cancer metastasis through inactivation of MMP9 by upregulation of TIMP-1. Int J Cancer. 2011; 129: 1586-98.
33. Guo C, Ding J, Yao L, et al. Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1. Int J Cancer. 2005; 116: 155-60.
34. Wei D, Gong W, Oh SC, et al. Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis. Cancer Res. 2005; 65: 4809-16.
35. Tanaka S, Shiraha H, Nakanishi Y, et al. Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma. Int J Cancer. 2012; 131: 2537-46.
36. Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008; 14: 818-29.
37. Kumarswamy R, Mudduluru G, Ceppi P, et al. MicroRNA-30a inhibits epithelial-to -mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int J Cancer. 2012; 130: 2044-53.
38. Cheng CW, Wang HW, Chang CW, et al. MicroRNA-30a inhibits cell migration and invasion by down regula- ting vimentin expression and is a potential prognostic marker in breast cancer. Breast Cancer Res Treat. 2012; 134: 1081-93.
39. Chang CJ, Chao CH, Xia W, et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol. 2011; 13(3): 317-23.
40. Kim T, Veronese A, Pichiorri F, et al. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med. 2011; 208: 875-83.
41. Sun L, Yao Y, Liu B, et al. MiR-200b and miR-15b regulate chemotherapy-induced epithelial- mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene. 2012; 31: 432-45.
42. Yamasaki T, Seki N, Yamada Y, et al. Tumor suppressive microRNA-138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma. Int J Oncol. 2012; 41: 805-17.