Cytotoxic mechanism of novel compound jiangxienone from Cordyceps jiangxiensis against cancer cells involving DNA damage response pathway

Process Biochemistry

Volumn 49, Issue 4, 2014, Pages 697-705

  Lü, Yu Hong ^a   Pan, Wei Dong ^a   Xiao, Jian Hui ^a   Sun, Zhong Hua ^a   Zhong, Jian Jiang ^b  

^a ZUNYI MEDICAL UNIVERSITY   (China)

^b Shanghai Jiao Tong University   (China)

Author keywords

Cordyceps jiangxiensis; Cytotoxic mechanism; DNA damage response pathway; Jiangxienone; Whole genome microarray

Indexed keywords

ABSORPTION SPECTROSCOPY; CELL CULTURE; CELL PROLIFERATION; CELLS; CYTOTOXICITY; DNA; ELECTROPHORESIS; EVOLUTIONARY ALGORITHMS;

CORDYCEPS JIANGXIENSIS; CYTOTOXIC MECHANISMS; DIFFERENTIAL GENE EXPRESSIONS; DNA DAMAGE RESPONSE; GASTRIC CANCER CELLS; GEL-RETARDATION ASSAY; JIANGXIENONE; SINGLE-CELL GEL ELECTROPHORESIS;

DAMAGE DETECTION;

BASIDIOMYCOTA; CORDYCEPS; CORDYCEPS JIANGXIENSIS; MURINAE;

EID: 84897914694     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2014.01.027     Document Type: Article

References (32)

1. J.J. Zhong, and J.H. Xiao Secondary metabolites from higher fungi: discovery, bioactivity, and bioproduction Adv Biochem Eng Biotechnol 113 2009 79 150
2. J.H. Xiao, and J.J. Zhong Secondary metabolites from Cordyceps species and their antitumor activity studies Recent Pat Biotechnol 1 2007 123 137
3. J. Holliday, and M. Cleaver Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review Int J Med Mushr 10 2008 219 234
4. M.A. Khan, M. Tania, D.Z. Zhang, and H.C. Chen Cordyceps mushroom: a potent anticancer nutraceutical Open Nutr J 3 2010 179 183
5. T.J. Yoon, K.W. Yu, K.S. Shin, and H.J. Suh Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture Appl Microbiol Biotechnol 80 2008 1087 1093
6. I. Molnár, D.M. Gibson, and S.B. Krasnoff Secondary metabolites from entomopathogenic Hypocrealean fungi Nat Prod Rep 27 2010 1241 1275
7. Z.Q. Liang, A.Y. Liu, and Z.Y. Liu Flora fungorum sinicorum Cordyceps 32 2007 Science Press Beijing, China
8. J.H. Xiao, D.X. Chen, J.W. Liu, Z.L. Liu, W.H. Wan, and N. Fang et al. Optimization of submerged culture requirements for the production of mycelial growth and exo-polysaccharide by Cordyceps jiangxiensis JXPJ 0109 J Appl Microbiol 96 2004 1105 1116
9. J.H. Xiao, D.X. Chen, W.H. Wan, X.J. Hu, Y. Qi, and Z.Q. Liang Enhanced simultaneous production of mycelia and intracellular polysaccharide in submerged cultivation of Cordyceps jiangxiensis using desirability functions Process Biochem 41 2006 1887 1893
10. J.H. Xiao, D.X. Chen, N. Fang, Z.L. Liu, and T. Zhang Growth arrest of human gastric adenocarcinoma cells by bioactive compounds of Cordyceps jiangxiensis (CaoMuWang) through induction of apoptosis J Food Agric Environ 4 3-4 2006 66 73
11. J.H. Xiao, and J.J. Zhong Inhibitory effect of polysaccharides produced by medicinal macrofungus Cordyceps jiangxiensis on cancer cells via apoptotic pathway and cell cycle arrest J Food Agric Environ 6 2 2008 61 67
12. J.H. Xiao, Z.H. Sun, W.D. Pan, and J.J. Zhong Secondary metabolite steroids isolated from medicinal entomogenous mushroom Cordyceps jiangxiensis mycelium Nat Prod Indian J 7 2011 118 123
13. J.H. Xiao, Z.H. Sun, W.D. Pan, Y.H. Lü, D.X. Chen, and J.J. Zhong Jiangxienone, a new compound with potent cytotoxicity against tumor cells from traditional Chinese medicinal mushroom Cordyceps jiangxiensis Chem Biodivers 9 2012 1349 1355
14. S.V. Sharma, D.A. Haber, and J. Settleman Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents Nat Rev Cancer 10 2010 241 253
15. A. Pessina, B. Albella, J. Bueren, P. Brantom, S. Casati, and L. Gribaldo et al. Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay Toxicol In Vitro 15 2001 729 740
16. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 2001 e45
17. R. Palchaudhuri, and P.J. Hergenrother DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action Curr Opin Biotechnol 18 2007 497 503
18. K.S. Nam, Y.S. Jo, Y.H. Kim, J.W. Hyun, and H.W. Kim Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes Life Sci 69 2001 229 237
19. G.S. Oh, K.H. Hong, H. Oh, H.O. Pae, I.K. Kim, and N.Y. Kim et al. 4-Acetyl-12,13-epoxyl-9-trichothecene-3,15-diol isolated from the fruiting bodies of Isaria japonica Yasuda induces apoptosis of human leukemia cells (HL-60) Biol Pharm Bull 24 2001 785 789
20. S. Hoelder, P.A. Clarke, and P. Workman Discovery of small molecule cancer drugs: successes, challenges and opportunities Mol Oncol 6 2012 155 176
21. A. Pessina, B. Albella, M. Bayo, J. Bueren, P. Brantom, and S. Casati et al. Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics Toxicol Sci 75 2003 355 367
22. D. Davidson, J. Grenier, V. Martinez-Marignac, L. Amrein, M. Shawi, and M. Tokars et al. Effects of the novel DNA dependent protein kinase inhibitor IC486241, on the DNA damage response to doxorubicin and cisplatin in breast cancer cells Invest New Drug 30 2012 1736 1742
23. F. Fattah, E.H. Lee, N. Weisensel, Y. Wang, N. Lichter, and E.A. Hendrickson Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells PLoS Genet 6 2010 e1000855
24. B.L. Mahaney, K. Meek, and S.P. Lees-Miller Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining Biochem J 417 2009 639 650
25. R.S. Williams, J.S. Williams, and J.A. Tainer Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template Biochem Cell Biol 85 2007 509 520
26. S.N. Andres, A. Vergnes, D. Ristic, C. Wyman, M. Modesti, and M. Junop A human XRCC4-XLF complex bridges DNA Nucleic Acids Res 40 2012 1868 1878
27. M.S. Tsai, Y.H. Kuo, Y.F. Chiu, Y.C. Su, and Y.W. Lin Down-regulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small-cell lung cancer cells J Pharmacol Exp Ther 335 2010 830 840
28. S.J. Boulton Cellular functions of the BRCA tumour-suppressor proteins Biochem Soc Transact 34 2006 633 645
29. A.R. Venkitaraman Functions of BRCA1 and BRCA2 in the biological response to DNA damage J Cell Sci 114 2001 3591 3598
30. R.D. Kennedy, J.E. Quinn, P.B. Mullan, P.G. Johnston, and D.P. Harkin The role of BRCA1 in the cellular response to chemotherapy J Natl Cancer Inst 96 2004 1659 1668
31. J. Ashby, H. Tinwell, P.A. Lefevre, and M.A. Browne The single cell gel electrophoresis assay for induced DNA damage (comet assay): measurement of tail length and moment Mutagenesis 10 1995 85 90
32. H. Ihmels, K. Faulhaber, D. Vedaldi, F. Dall'Acqua, and G. Viola Intercalation of organic dye molecules into double-stranded DNA, part 2: the annelated quinolizinium ion as a structural motif in DNA intercalators Photochem Photobiol 81 2005 1107 1115