Epidemiology of low back pain in Adults

Neuromodulation

Volumn 17, Issue S2, 2014, Pages 3-10

  Manchikanti, Laxmaiah ^a,b   Singh, Vijay ^c   Falco, Frank J E ^d,e   Benyamin, Ramsin M ^f   Hirsch, Joshua A ^g  

^a PAIN MANAGEMENT CENTER OF PADUCAH   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c Spine Pain Diagnostics Associates   (United States)

^d Mid Atlantic Spine and Pain Physicians   (United States)

^e TEMPLE UNIVERSITY HOSPITAL   (United States)

^f UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Chronic low back pain; Comorbid factors; Health care utilization; Loss of productivity; Socioeconomic effects

Indexed keywords

ADULT; AGING; ARTICLE; COMORBIDITY; DEGENERATIVE DISEASE; DISEASE COURSE; HEALTH CARE COST; HUMAN; LOW BACK PAIN; MENTAL DISEASE; OBESITY; OCCUPATIONAL EXPOSURE; PREVALENCE; PROGNOSIS; PSYCHOLOGICAL ASPECT; RISK FACTOR; SEDENTARY LIFESTYLE; SEX DIFFERENCE; SMOKING; SOCIOECONOMICS; UNITED STATES;

ADULT; HUMANS; LOW BACK PAIN; PREVALENCE; UNITED STATES;

EID: 84897898742     PISSN: 10947159     EISSN: 15251403     Source Type: Journal    
DOI: 10.1111/ner.12018     Document Type: Article

References (134)

1. Manchikanti L, Singh V, Datta S, Cohen SP, Hirsch JA. Comprehensive review of epidemiology, scope, and impact of spinal pain. Pain Physician 2009;12:E35-E70
2. Hoy D, Bain C, Williams G et al.A systematic review of the global prevalence of low back pain. Arthritis Rheum 2012;64:2028-2037
3. Briggs AM, Jordan JE, O'Sullivan PB et al. Individuals with chronic low back pain have greater difficulty in engaging in positive lifestyle behaviours than those without back pain: An assessment of health literacy. BMC Musculoskelet Disord 2011;12:161
4. Ferreira ML,Machado G,Latimer J,Maher C,Ferreira PH,Smeets RJ.Factors defining care-seeking in low back pain-A meta-Analysis of population based surveys. Eur J Pain 2010;14:747. e1-e7
5. Gignac MA, Davis AM, Hawker G et al. "What do you expect? You're just getting older": A comparison of perceived osteoarthritis-related and aging-related health experiences in middle- and older-Age adults. Arthritis Rheum 2006;55:905-912
6. Griffin DW,Harmon DC,Kennedy NM.Do patients with chronic low back pain have an altered level and/or pattern of physical activity compared to healthy individuals? A systematic review of the literature. Physiotherapy 2012;98:13-23
7. Leboeuf-Yde C, Fejer R, Nielsen J, Kyvik KO, Hartvigsen J. Pain in the three spinal regions: The same disorder? Data from a population-based sample of 34,902 Danish adults. Chiropr Man Therap 2012;20:11
8. Martin BI, Deyo RA, Mirza SK et al. Expenditures and health status among adults with back and neck problems. JAMA 2008;299:656-664
9. Martin BI, Turner JA,Mirza SK, Lee MJ,Comstock BA,Deyo RA. Trends in health care expenditures, utilization, and health status among US adults with spine problems, 1997-2006. Spine 2009;34:2077-2084
10. Leigh JP. Economic burden of occupational injury and illness in the United States. Milbank Q 2011;89:728-772
11. Bhushan A,Leigh JP.National trends in occupational injuries before and after 1992 and predictors of workers' compensation costs. Public Health Rep 2011;126:625-634
12. Gaskin DJ, Richard P. The economic costs of pain in the United States. J Pain 2012;13:715-724
13. Maniadakis N, Gray A. The economic burden of back pain in the UK. Pain 2000;84:95-103
14. Dagenais S,Caro J,Haldeman S.A systematic review of lowback pain cost of illness studies in the United States and internationally. Spine J 2008;8:8-20
15. Asche CV, Kirkness CS, McAdam-Marx C, Fritz JM. societal costs of low back pain: Data published between 2001 and 2007. J Pain Palliat Care Pharmacother 2007;21:25-33
16. Becker A, Held H, Redaelli M et al. Low back pain in primary care: Costs of care and prediction of future health care utilization. Spine 2010;35:1714-1720
17. Pryce R, Johnson M,Goytan M, Passmore S, Berrington N, Kriellaars D. Relationship between ambulatory performance and self-rated disability in patients with lumbar spinal stenosis. Spine 2012;37:1316-1323
18. Kelly-Hayes M, Jette AM,Wolf PA, D'Agostino RB, Odell PM. Functional limitations and disability among elders in the Framingham Study. Am J Public Health 1992;82:841-845
19. Cecchi F, Debolini P, Lova RM et al. Epidemiology of back pain in a representative cohort of Italian persons 65 years of age and older: The InCHIANTI study. Spine 2006;31:1149-1155
20. Bressler HB, Keyes WJ, Rochon PA, Badley E. The prevalence of low back pain in the elderly. A systematic review of the literature. Spine 1999;24:1813-1819
21. Dionne CE, Dunn KM, Croft PR. Does back pain prevalence really decrease with increasing age? A systematic review. Age Ageing 2006;35:229-234
22. Deyo RA,Mirza SK,Martin BI. Back pain prevalence and visit rates: Estimates from U.S. national surveys, 2002. Spine 2006;31:2724-2727.
23. von Korff M, Dworkin SF, Le Resche L, Kruger A. An epidemiologic comparison of pain complaints. Pain 1988;32:173-183
24. von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain. Pain 1992;50:133-149
25. Cassidy JD, Carroll LJ, Côté P. The Saskatchewan Health and Back Pain Survey.The prevalence of low back pain and related disability in Saskatchewan adults. Spine 1998;23:1860-1867
26. Nachemson AL. Newest knowledge of low back pain. A critical look. Clin Orthop 1992;279:8-20
27. Leigh JP, Markowitz SB, Fahs M, Shin C, Landrigan PJ. Occupational injury and illness in the United States. Estimates of costs, morbidity, and mortality.Arch Intern Med 1997;157:1557-1568
28. Guo HR,Tanaka S,Cameron LL et al.Back pain among workers in the United States. National estimates and workers at high risk.Am J Ind Med 1995;28:591-602
29. Rautiainen RH, Ohsfeldt R, Sprince NL et al. Cost of compensated injuries and occupational diseases in agriculture in Finland. J Agromedicine 2005;10:21-29
30. Leigh JP, Robbins JA.Occupational disease and workers' compensation: Coverage, costs, and consequences.Milbank Q 2004;82:689-721
31. Waehrer G, Leigh JP, Cassady D,Miller TR. Costs of occupational injury and illness across states. J Occup Environ Med 2004;46:1084-1095
32. Leigh JP,Waehrer G,Miller TR,McCurdy SA. Costs differences across demographic groups and types of occupational injuries and illnesses.AmJ Ind Med 2006;49:845-853
33. Dunning KK, Davis KG, Cook C et al. Costs by industry and diagnosis among musculoskeletal claims in a state workers compensation system: 1999-2004.Am J Ind Med 2010;53:276-284
34. Freburger JK,Holmes GM,Agans RP et al.The rising prevalence of chronic lowback pain. Arch Intern Med 2009;169:251-258
35. Centers for Disease Control and Prevention. Behavioral Risk Factor Surveillance System: Centers for Disease Control. Atlanta, GA: US Department of Health and Human Services, 2008. http://www.cdc.gov/brfss/index.htm.
36. Kerr MS, Frank JW, Shannon HS et al. Biomechanical and psychosocial risk factors for low back pain at work. Am J Public Health 2001;91:1069-1075
37. Mailis-Gagnon A, Nicholson K, Yegneswaran B, Zurowski M. Pain characteristics of adults 65 years of age and older referred to a tertiary care pain clinic. Pain Res Manag 2008;13:389-394
38. Raspe H, Hueppe A,Neuhauser H. Back pain, a communicable disease? Int J Epidemiol 2008;37:69-74
39. Social Security Administration. Annual Statistical Report on the Social Security Disability Insurance Program, 2011. Baltimore, MD: Office of Research Evaluation and Statistics, 2011. Accessed on 8/17/2012. http://www.ssa.gov/policy/docs/statcomps/di-Asr/2011/di-Asr11.pdf
40. Deyo RA, Mirza SK, Turner JA, Martin BI. Overtreating chronic back pain: Time to back off? J Am Board Fam Med 2009;22:62-68
41. Manchikanti L,Helm S II, Fellows B et al. Opioid epidemic in the United States. Pain Physician 2012;15 (3 Suppl.):ES9-ES38
42. Deyo RA, Smith DH, Johnson ES et al. Opioids for back pain patients: Primary care prescribing patterns and use of services. J Am Board Fam Med 2011;24:717-727
43. Manchikanti L, Abdi S, Atluri S et al. American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: Part 2-Guidance. Pain Physician 2012;15 (3 Suppl.):S67-S116
44. Manchikanti L,Pampati V,Falco FJE, Hirsch JA.Growth of spinal interventional pain management techniques:analysis of utilization trends and medicare expenditures 2000 to 2008. Spine 2012; July 11 [Epub ahead of print].
45. Manchikanti L, Parr AT, Singh V, Fellows B. Ambulatory surgery centers and interventional techniques: A look at long-Term survival. Pain Physician 2011;14:E177-E215
46. Manchikanti L, Singh V, Caraway DL, Benyamin RM, Hirsch JA.Medicare physician payment systems: impact of 2011 schedule on interventional pain management. Pain Physician 2011;14:E5-E33
47. Specialty Utilization data files from CMS: http://www.cms.hhs.gov/
48. Department of Health and Human Services, Centers for Medicare & Medicaid Services. 42 CFR Parts 410, 414, 415, and 495.Medicare Program; Payment Policies Under the Physician Fee Schedule, Five-Year Review of Work Relative Value Units, Clinical Laboratory Fee Schedule: Signature on Requisition, and Other Revisions to Part B for CY 2012. Final Rule. November 28, 2011
49. Department of Health and Human Services, Centers for Medicare & Medicaid Services. 42 CFR Parts 410, 411, 416, 419, 489, and 495. Medicare and Medicaid Programs: Hospital Outpatient Prospective Payment; Ambulatory Surgical Center Payment; Hospital Value-Based Purchasing Program; Physician Self-Referral; and Provider Agreement Regulations on Patient Notification Requirements. Final Changes to the Hospital Outpatient Prospective Payment System and CY 2012 Payment Rates. November 30, 2011
50. Manchikanti L, Falco FJE, Singh V et al. Utilization patterns of interventional techniques in managing chronic pain in the Medicare population: Analysis of growth from 2000 to 2011. Pain Physician 2012; in press
51. Hüppe A, Müller K,Raspe H. Is the occurrence of back pain in Germany decreasing? Two regional postal surveys a decade apart. Eur J Public Health 2007;17:318-322
52. Shekelle PG, Markovich M, Louie R. An epidemiologic study of episodes of back pain care. Spine 1995;20:1668-1673
53. Anderson GBJ,Svensson HO.The intensity of work recovery in low back pain. Spine 1983;8:880-887
54. Eriksen J, Ekholm O, Sjøgren P, Rasmussen NK.Development of and recovery from long-Term pain. A 6-year follow-up study of a cross-section of the adult Danish population. Pain 2004;108:154-162
55. Kadam UT, Thomas E, Croft PR. Is chronic widespread pain a predictor of all-cause morbidity? A 3 year prospective population based study in family practice. J Rheumatol 2005;32:1341-1348
56. Stanford EA, Chamber CT, Biesanz JC, Chen E. The frequency, trajectories and predictors of adolescent recurrent pain: A population-based approach. Pain 2008;138:11-21
57. Cassidy JD, Côté P, Carroll LJ, Kristman V. Incidence and course of low back pain episodes in the general population. Spine 2005;30:2817-2823
58. Hestbaek L, Leboeuf-Yde C, Manniche C. Low back pain: what is the long-Term course? A review of studies of general patient populations. Eur Spine J 2003;12:149-165
59. Enthoven P, Skargren E, Oberg B. Clinical course in patients seeking primary care for back or neck pain: A prospective 5-year follow-up of outcome and health care consumption with subgroup analysis. Spine 2004;29:2458-2465
60. Miedema HS, Chorus AM,Wevers CW, van der Linden S. Chronicity of back problems during working life. Spine 1998;23:2021-2028
61. Mortimer M, Pernold G, Wiktorin C. Low back pain in a general population. Natural course and influence of physical exercise-A 5-year follow-up of the Musculoskeletal Intervention Center- Norrtälje Study. Spine 2006;31:3045-3051
62. Hestbaek L, Leboeuf-Yde C, Engberg M, Lauritzen T, Bruun NH, Manniche C. The course of low back pain in a general population. Results from a 5-year prospective study. J Manipulative Physiol Ther 2003;26:213-219
63. Stanton TR, Henschke N,Maher CG, Refshauge KM, Latimer J,McAuley JH.After an episode of acute lowback pain, recurrence is unpredictable and not as common as previously thought. Spine 2008;33:2923-2928
64. Croft PR, Papageorgiou AC, Ferry S, Thomas E, Jayson MI, Silman AJ. Psychologic distress and low back pain: Evidence from a prospective study in the general population. Spine 1995;20:2731-2737
65. Larson SL, Clark MR,Eaton WW.Depressive disorder as a long-Term antecedent risk factor for incident back pain: A 13-year follow-up study from the Baltimore Epidemiological Catchment Area sample. Psychol Med 2004;34:211-219
66. Currie SR,Wang J. More data on major depression as an antecedent risk factor for first onset of chronic back pain. Psychol Med 2005;35:1275-1282
67. Bergström G, Bodin L, Bertilsson H, Jensen IB. Risk factors for new episodes of sick leave due to neck or back pain in a working population. A prospective study with an 18-month and a three-year follow-up. Occup Environ Med 2007;64:279-287
68. Schmidt CO,Raspe H, PfingstenMet al. Back pain in the German adult population: Prevalence, severity, and sociodemographic correlates in a multiregional survey. Spine 2007;32:2005-2011
69. Sitthipornvorakul E, Janwantanakul P, Purepong N, Pensri P, van der Beek AJ. The association between physical activity and neck and low back pain: A systematic review. Eur Spine J 2011;20:677-689
70. Hamberg-Van Reenen HH, Ariëns GA, Blatter BM, van Mechelen W, Bongers PM. A systematic review of the relation between physical capacity and future low back and neck/shoulder pain. Pain 2007;130:93-107
71. Cohen SP, Argoff CE, Carragee EJ. Management of low back pain. BMJ 2008;337:A2718
72. Bonezzi C, Demartini L, Buonocore M. Chronic pain: Not only a matter of time. Minerva Anestesiol 2012;78:704-711
73. Azevedo LF, Cost-Pereira A,Mendonça L, Dias CC, Castro-Lopes JM. Epidemiology of chronic pain: A population-based nationwide study on its prevalence, characteristics and associated disability in Portugal. J Pain 2012;13:773-783
74. Björck-Van Dijken C, Fjellman-Wiklund A, Hildingsson C. Low back pain, lifestyle factors and physical activity:A population based-study.J Rehabil Med 2008;40:864-869
75. Ochsmann EB,Rueger H,Letzel S,Drexler H,Muenster E.Over-indebtedness and its association with the prevalence of back pain. BMC Public Health 2009;9:451
76. Heuch I,Hagen K,Heuch I.Nygaard Ø,Zwart JA.The impact of body mass index on the prevalence of low back pain: The HUNT study. Spine 2010;35:764-768
77. Verkerk K, Luijsterburg PA,Miedema HS, Pool-Goudzwaard A, Koes BW. Prognostic factors for recovery in chronic nonspecific low back pain: A systematic review. Phys Ther 2012 doi:10.2522/ptj.20110388. Jun 21. [Epub ahead of print]
78. Ritzwoller DP, Crounse L, Shetterly S, Rublee D. The association of comorbidities, utilization and costs for patients identified with low back pain.BMC Musculoskelet Disord 2006;7:72
79. Linton SJ, Buer N, Vlaeyen JW, Hellsing AL. Are fear-Avoidance beliefs related to the inception of an episode of back pain? A prospective study. Psychol Health 2000;14:1051-1059
80. Mannion AF, Dolan P, Adams MA. Psychological questionnaires: Do "abnormal" scores precede or follow first time low back pain? Spine 1996;21:2603-2611
81. Schiphorst Preuper HR, Reneman MF, Boonstra AM et al. Relationship between psychological factors and performance-based and self-reported disability in chronic low back pain. Eur Spine J 2008;17:1448-1456
82. Truchon M, Côté D, Fillion L, Arsenault B, Dionne C. Low-back-pain related disability: An integration of psychological risk factors into the stress process model. Pain 2008;137:564-573
83. Shaw WS,Means-Christensen A, Slater MA, Patterson TL,Webster JS, Atkinson JH. Shared and independent associations of psychosocial factors on work status among men with subacute low back pain. Clin J Pain 2007;23:409-416
84. Kovacs F, Noguera J, Abraira V et al. The influence of psychological factors on low back pain-related disability in community dwelling older persons. Pain Med 2008;9:871-880
85. Macfarlane GJ,Thomas E,Papageorgiou AC,Croft PR, Jayson MI,Silman AJ.Employment and physical work activities as predictors of future low back pain. Spine 1997;22:1143-1149
86. Harkness EF, Macfarlane GJ, Nahit ES, Silman AJ, McBeth J. Risk factors for newonset low back pain amongst cohorts of newly employed workers. Rheumatology (Oxford) 2003;42:959-968
87. Vingård E, Alfredsson L, Hagberg M et al. To what extent do current and past physical and psychosocial occupational factors explain care-seeking for low back pain in a working population? Results from the Musculoskeletal Intervention Center-Norrtälje Study. Spine 2000;25:493-500
88. Thorbjörnnson CB, Alfredsson L, Fredrikkson K et al. Psychosocial and physical risk factors associated with low back pain: A 24-year follow-up among women and men in a broad range of occupations. Occup Environ Med 1998;55:84-90
89. Leigh JP, Miller TR. Ranking occupations based upon the costs of job-related injuries and diseases. J Occup Environ Med 1997;39:1170-1182
90. Battié MC, Videman T, Kaprio J et al. The Twin Spine Study: Contributions to a changing view of disc degeneration. Spine J 2009;9:47-59
91. Gruber GJ. Relationships Between Whole-Body Vibration and Mobility Patterns Among Interstate Truck Drivers.Washington, DC: US Department of Health, Education, and Welfare, DHEW (NIOSH) Publication No. 77-167. 1976
92. Palmer KT, Harris EC, Griffin MJ et al. Case-control study of low-back pain referred for magnetic resonance imaging, with special focus on whole-body vibration. Scand JWork Environ Health 2008;34:364-373
93. Janwantanakul P, Pensri P, Jiamjarasrangsri V, Sinsongsook T. Prevalence of selfreported musculoskeletal symptoms among office workers. Occup Med (Lond) 2008;58:436-438
94. Kjellberg A,Wikström BO, Landström U. Injuries and other adverse effects of occupational exposure to whole-body vibration: A review for criteria documentation. Arbete Och Hälsa 1994;41:1-74
95. Müller CF, Monrad T, Biering-Sørensen F, Darre E, Deis A, Kryger P. The influence of previous low back trouble, general health, and working conditions on future sick-listing because of low back trouble. A 15-year follow-up study of risk indicators for self-reported sick-listing caused by low back trouble. Spine 1999;24: 1562-1570
96. Du J, Leigh JP. Incidence of workers compensation indemnity claims across sociodemographic and job characteristics.Am J Ind Med 2011;54:758-770
97. Leigh JP,Hubert HB,Romano PS. Lifestyle risk factors predict healthcare costs in an aging cohort.Am J Prev Med 2005c;29:379-387
98. Webb R, Brammah T, Lunt M, Urwin M, Allison T, Symmons D. Prevalence and predictors of intense, chronic, and disabling neck and back pain in the UK general population. Spine 2003;28:1195-1202
99. Linton SJ. Do psychological factors increase the risk for back pain in the general population in both a cross-sectional and prospective analysis? Eur J Pain 2005;9:355-361
100. Deyo RA, Bass JE. Lifestyle and low back pain. The influence of smoking and obesity. Spine 1989;14:501-506
101. Shiri R, Solovieva S, Husgafvel-Pursiainen K et al. The association between obesity and the prevalence of low back pain in young adults: The cardiovascular risk in young Finns study.Am J Epidemiol 2008;167:1110-1119
102. Leboeuf-Yde C.Bodyweight and lowback pain:A systematic literature review of 56 journal articles reporting on 65 epidemiologic studies. Spine 2000;25:226-237
103. Croft PR,Rigby AS. Socioeconomic influences on back problems in the community in Britain. J Epidemiol Community Health 1994;48:166-170
104. Leboeuf-Yde C. Smoking and low back pain. A systematic literature review of 41 journal articles reporting 47 epidemiologic studies. Spine 1999;24:1463-1470
105. Leboeuf-Yde C, Kyvik KO, Bruun NH. Low back pain and lifestyle. Part I. Smoking: information from a population based sample of 29,424 twins. Spine 1998;23:2207-2214
106. John U, Alte D, Hanke M, Meyer C, Völzke H, Schumann A. Tobacco smoking in relation to analgesic drug use in a national adult population sample. Drug Alcohol Depend 2006;85:49-55
107. Vogt MT, Hanscom B, Lauerman WC, Kang JD. Influence of smoking on the health status of spinal patients:The National Spine Network Database.Spine 2002;27:313-319
108. Battie MC,Videman T, Gibbons LE, Fisher LD,Manninen H, Gill K. 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 1995;20:2601-2612
109. Battie MC, Haynor DR, Fisher LD, Gill K, Gibbons LE, Videman T. Similarities in degenerative findings on magnetic resonance images of the lumbar spines of identical twins. J Bone Joint Surg Am 1995;77:1662-1670
110. Koch H,Smith MC.Office-based ambulatory care for patients 75 years old and over: National AmbulatoryMedical Care Survey,1980 and 1981.Advance data fromvital and health statistics. National Center for Health Statistics (NCHS). No. 110. DHHS Pub. No. (PHS) 85-1250. Hyattsville, MD: Public Health Service, 1985;110:1-14.
111. Goel V, Iron K, Williams JI. Indicators of health determinants and health status. In: Goel V, Williams JI, Anderson GM, Blackstien-Hirsch P, Fooks C, Naylor CD, eds. Patterns of Health Care in Ontario.The ICES Practice Atlas,2nd ed.Ottawa,ON:Canadian Medical Association, 1996; pp 5-26
112. Pleis JR, Lethbridge-Çejku M. Summary health statistics for U.S. adults: National Health Interview Survey, 2006. National Center for Health Statistics. Vital Health Stat 10 2007;235:1-153
113. Kristiansson P, Svärdsudd K, von Schoultz B. Back pain during pregnancy. A prospective study. Spine 1996;21:702-709
114. Thorell E, Kristiansson P. Pregnancy related back pain, is it related to aerobic fitness? A longitudinal cohort study. BMC Pregnancy Childbirth 2012;12:30
115. Olsson CB, Grooten WJ, Nilsson-Wikmar L, Harms-Ringdahl K, Lundberg M. Catastrophizing during and after pregnancy: Associations with lumbopelvic pain and postpartum physical ability. Phys Ther 2012;92:49-57
116. Kovacs FM, Garcia E, Royuela A, González L, Abraira V, the Spanish Back Pain Research Network. Prevalence and factors associated with low back pain and pelvic girdle pain during pregnancy:A multicenter study conducted in the Spanish National Health Service. Spine 2012;37:1516-1533
117. Pennick VE, Young G. Interventions for preventing and treating pelvic and back pain in pregnancy. Cochrane Database Syst Rev 2007;(2)CD001139
118. Wu WH, Meijer OG, Uegaki K et al. Pregnancy-related pelvic girdle pain (PPP) I: Terminology, clinical presentation, and prevalence. Eur Spine J 2004;13:575-589
119. Bastiaanssen JM, de Bie RA, Bastiaenen CH, Essed GG, van den Brandt PA.A historical perspective on pregnancy-related low back and/or pelvic girdle pain. Eur J Obstet Gynecol Reprod Biol 2005;120:3-14
120. Akyüz G, Ozkök O. Evidence based rehabilitation in chronic pain syndromes. Agri 2012;24:97-103
121. Ohayon MM,Stingl JC. Prevalence and comorbidity of chronic pain in the German general population. J Psychiatr Res 2012;46:444-450
122. Haldeman S, Kopansky-Giles D, Hurwitz EL et al. Advancements in the management of spine disorders. Best Pract Res Clin Rheumatol 2012;26:263-280
123. Ratcliffe GE, Enns MW, Belik S, Sareen J. Chronic pain conditions and suicidal ideation and suicide attempts. An epidemiologic perspective. Clin J Pain 2008;24:204-210
124. Merikangas KR, Ames M, Cui L et al. The impact of comorbidity of mental and physical conditions on role disability in the US adult household population. Arch Gen Psychiatry 2007;64:1180-1188
125. Martin BI,Mirza SK, Comstock BA, Gray DT, Kreuter W, Deyo RA. Are lumbar spine reoperation rates falling with greater use of fusion surgery and new surgical technology? Spine 2007;32:2119-2126
126. Saastamoinen P, Leino-Arjas P, Laaksonen M, Lahelma E. Socio-economic differences in the prevalence of acute, chronic and disabling chronic pain among ageing employees. Pain 2005;114:364-371
127. Webster BS, Verma SK, Gatchel RJ. Relationship between early opioid prescribing for acute occupational low back pain and disability duration, medical costs, subsequent surgery and late opioid use. Spine 2007;32:2127-2132
128. Ricci JA, Stewart WF, Chee E, Leotta C, Foley K, Hochberg MC. Back pain exacerbations and lost productive time costs in United States workers. Spine 2006;31:3052-3060
129. White AG, Birnbaum HG, Mareva MN et al. Direct costs of opioid abuse in an insured population in the United States. J Manag Care Pharm 2005;11:469-479
130. Luo X, Pietrobon R, Sun SX, Liu GG, Hey L. Estimates and patterns of direct health care expenditures among individuals with back pain in the United States. Spine 2004;29:79-86
131. Manchikanti L, Vallejo R,Manchikanti KN, Benyamin RM, Datta S, Christo PJ. Effectiveness of long-Term opioid therapy for chronic non-cancer pain. Pain Physician 2011;14:E133-E156
132. Hurwitz EL, Morgenstern H, Yu F. Cross-sectional and longitudinal associations of low-back pain and related disability with psychological distress among patients enrolled in the UCLA Low-Back Pain Study. J Clin Epidemiol 2003;56:463-471
133. Walker BF, Muller R, Grant WD. Low back pain in Australian adults: The economic burden. Asia Pac J Public Health 2003;15:79-87
134. Jhawar BS, Fuchs CS, Colditz GA, Stampfer MJ. Cardiovascular risk factors for physician-diagnosed lumbar disc herniation. Spine J 2006;6:684-691.