메뉴 건너뛰기




Volumn 41, Issue 4, 2014, Pages 301-308

Bitter tastants induce relaxation of rat thoracic aorta precontracted with high K+

Author keywords

Bitter tastants; Chloroquine; Intracellular Ca2+; L type Ca2+ channels; Patch clamp; Relaxation

Indexed keywords

CALCIUM ION; CHLOROQUINE; DENATONIUM BENZOATE; NIFEDIPINE; PERTUSSIS TOXIN; POTASSIUM;

EID: 84897872128     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12217     Document Type: Article
Times cited : (16)

References (30)
  • 1
    • 84897909368 scopus 로고    scopus 로고
    • World Health Organization. World Health Statistics 2012. Available from: (accessed 7 October 2013).
    • World Health Organization. World Health Statistics 2012. 2012. Available from: http://www.who.int/gho/publications/world_health_statistics/EN_WHS2012_Full.pdf (accessed 7 October 2013).
    • (2012)
  • 2
    • 84897869402 scopus 로고    scopus 로고
    • World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. Available from: (accessed 8 October 2013).
    • World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. 2002. Available from: http://www.who.int/whr/2002/en/whr02_en.pdf (accessed 8 October 2013).
    • (2002)
  • 3
    • 74049148597 scopus 로고    scopus 로고
    • Protective effects of vasonatrin peptide against hypobaric hypoxia-induced pulmonary hypertension in rats
    • Yu J, Feng HS, Chen BY et al. Protective effects of vasonatrin peptide against hypobaric hypoxia-induced pulmonary hypertension in rats. Clin. Exp. Pharmacol. Physiol. 2010; 37: 69-74.
    • (2010) Clin. Exp. Pharmacol. Physiol. , vol.37 , pp. 69-74
    • Yu, J.1    Feng, H.S.2    Chen, B.Y.3
  • 4
    • 84864323690 scopus 로고    scopus 로고
    • Rosiglitazone, a peroxisome proliferator-activated receptor gamma stimulant, abrogates diabetes-evoked hypertension by rectifying abnormalities in vascular reactivity
    • El-Bassossy HM, Abo-Warda SM, Fahmy A. Rosiglitazone, a peroxisome proliferator-activated receptor gamma stimulant, abrogates diabetes-evoked hypertension by rectifying abnormalities in vascular reactivity. Clin. Exp. Pharmacol. Physiol. 2012; 39: 643-9.
    • (2012) Clin. Exp. Pharmacol. Physiol. , vol.39 , pp. 643-649
    • El-Bassossy, H.M.1    Abo-Warda, S.M.2    Fahmy, A.3
  • 5
    • 84860226420 scopus 로고    scopus 로고
    • Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib
    • Nagasawa T, Hye Khan MA, Imig JD. Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib. Clin. Exp. Pharmacol. Physiol. 2012; 39: 454-61.
    • (2012) Clin. Exp. Pharmacol. Physiol. , vol.39 , pp. 454-461
    • Nagasawa, T.1    Hye Khan, M.A.2    Imig, J.D.3
  • 7
    • 0031586885 scopus 로고    scopus 로고
    • Science, medicine, and the future. Hypertension
    • Brown MJ. Science, medicine, and the future. Hypertension. BMJ 1997; 314: 1258-61.
    • (1997) BMJ , vol.314 , pp. 1258-1261
    • Brown, M.J.1
  • 8
    • 79954621266 scopus 로고    scopus 로고
    • Benefit assessment of salt reduction in patients with hypertension: Systematic overview
    • Matyas E, Jeitler K, Horvath K et al. Benefit assessment of salt reduction in patients with hypertension: Systematic overview. J. Hypertens. 2011; 29: 821-8.
    • (2011) J. Hypertens. , vol.29 , pp. 821-828
    • Matyas, E.1    Jeitler, K.2    Horvath, K.3
  • 9
    • 84867742487 scopus 로고    scopus 로고
    • Combination therapy improves exercise capacity and reduces risk of clinical worsening in patients with pulmonary arterial hypertension: A meta-analysis
    • Zhu B, Wang L, Sun L, Cao R. Combination therapy improves exercise capacity and reduces risk of clinical worsening in patients with pulmonary arterial hypertension: A meta-analysis. J. Cardiovasc. Pharmacol. 2012; 60: 342-6.
    • (2012) J. Cardiovasc. Pharmacol. , vol.60 , pp. 342-346
    • Zhu, B.1    Wang, L.2    Sun, L.3    Cao, R.4
  • 10
    • 80051798193 scopus 로고    scopus 로고
    • Management of hypertension in the young: Role of antihypertensive medications
    • Flynn JT. Management of hypertension in the young: Role of antihypertensive medications. J. Cardiovasc. Pharmacol. 2011; 58: 111-20.
    • (2011) J. Cardiovasc. Pharmacol. , vol.58 , pp. 111-120
    • Flynn, J.T.1
  • 11
    • 77957603729 scopus 로고    scopus 로고
    • Targeting hypertension with a new adenosine triphosphate-sensitive potassium channel opener iptakalim
    • Pan Z, Huang J, Cui W, Long C, Zhang Y, Wang H. Targeting hypertension with a new adenosine triphosphate-sensitive potassium channel opener iptakalim. J. Cardiovasc. Pharmacol. 2010; 56: 215-28.
    • (2010) J. Cardiovasc. Pharmacol. , vol.56 , pp. 215-228
    • Pan, Z.1    Huang, J.2    Cui, W.3    Long, C.4    Zhang, Y.5    Wang, H.6
  • 12
    • 0023039117 scopus 로고
    • Cardiovascular toxicity and distribution kinetics of intravenous chloroquine
    • Looareesuwan S, White NJ, Chanthavanich P et al. Cardiovascular toxicity and distribution kinetics of intravenous chloroquine. Br. J. Clin. Pharmacol. 1986; 22: 31-6.
    • (1986) Br. J. Clin. Pharmacol. , vol.22 , pp. 31-36
    • Looareesuwan, S.1    White, N.J.2    Chanthavanich, P.3
  • 13
    • 0033064403 scopus 로고    scopus 로고
    • Chloroquine influences renal function in rural Zimbabweans with acute transient fever
    • Musabayane CT, Musvibe A, Wenyika J, Munjeri O, Osim EE. Chloroquine influences renal function in rural Zimbabweans with acute transient fever. Ren. Fail. 1999; 21: 189-97.
    • (1999) Ren. Fail. , vol.21 , pp. 189-197
    • Musabayane, C.T.1    Musvibe, A.2    Wenyika, J.3    Munjeri, O.4    Osim, E.E.5
  • 15
    • 0027399741 scopus 로고
    • Chloroquine reduces blood pressure and forearm vascular resistance and increases forearm blood flow in healthy young adults
    • Anigbogu CN, Adigun SA, Inyang I, Adegunloye BJ. Chloroquine reduces blood pressure and forearm vascular resistance and increases forearm blood flow in healthy young adults. Clin. Physiol. 1993; 13: 209-16.
    • (1993) Clin. Physiol. , vol.13 , pp. 209-216
    • Anigbogu, C.N.1    Adigun, S.A.2    Inyang, I.3    Adegunloye, B.J.4
  • 16
    • 0027960814 scopus 로고
    • The effects of oral chloroquine administration on kidney function
    • Musabayane CT, Ndhlovu CE, Balment RJ. The effects of oral chloroquine administration on kidney function. Ren. Fail. 1994; 16: 221-8.
    • (1994) Ren. Fail. , vol.16 , pp. 221-228
    • Musabayane, C.T.1    Ndhlovu, C.E.2    Balment, R.J.3
  • 17
    • 84877579453 scopus 로고    scopus 로고
    • Relaxant effect of chloroquine in rat ileum. Possible involvement of nitric oxide and BKCa
    • Jing F, Liu M, Yang N, Liu Y, Li X, Li J. Relaxant effect of chloroquine in rat ileum. Possible involvement of nitric oxide and BKCa. J. Pharm. Pharmacol. 2013; 65: 847-54.
    • (2013) J. Pharm. Pharmacol. , vol.65 , pp. 847-854
    • Jing, F.1    Liu, M.2    Yang, N.3    Liu, Y.4    Li, X.5    Li, J.6
  • 18
    • 84876367698 scopus 로고    scopus 로고
    • Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation
    • Long L, Yang X, Southwood M et al. Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. Circ. Res. 2013; 112: 1159-70.
    • (2013) Circ. Res. , vol.112 , pp. 1159-1170
    • Long, L.1    Yang, X.2    Southwood, M.3
  • 19
    • 84874789268 scopus 로고    scopus 로고
    • Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression
    • Lund TC, Kobs AJ, Kramer A et al. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. PLoS One 2013; 8: e58945.
    • (2013) PLoS One , vol.8
    • Lund, T.C.1    Kobs, A.J.2    Kramer, A.3
  • 20
    • 0141644225 scopus 로고    scopus 로고
    • Effects of chloroquine on smooth muscle contracted with noradrenaline or high-potassium solutions in the rat thoracic aorta
    • Aziba PI, Okpako DT. Effects of chloroquine on smooth muscle contracted with noradrenaline or high-potassium solutions in the rat thoracic aorta. J. Smooth Muscle Res. 2003; 39: 31-7.
    • (2003) J. Smooth Muscle Res. , vol.39 , pp. 31-37
    • Aziba, P.I.1    Okpako, D.T.2
  • 21
    • 78149355561 scopus 로고    scopus 로고
    • Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction
    • Deshpande DA, Wang WC, McIlmoyle EL et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat. Med. 2010; 16: 1299-304.
    • (2010) Nat. Med. , vol.16 , pp. 1299-1304
    • Deshpande, D.A.1    Wang, W.C.2    McIlmoyle, E.L.3
  • 22
    • 84860695562 scopus 로고    scopus 로고
    • Activation of BK channels may not be required for bitter tastant-induced bronchodilation
    • Zhang CH, Chen C, Lifshitz LM, Fogarty KE, Zhu MS, ZhuGe R. Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nat. Med. 2012; 18: 648-50.
    • (2012) Nat. Med. , vol.18 , pp. 648-650
    • Zhang, C.H.1    Chen, C.2    Lifshitz, L.M.3    Fogarty, K.E.4    Zhu, M.S.5    ZhuGe, R.6
  • 23
    • 66349134438 scopus 로고    scopus 로고
    • Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells
    • Liu QH, Zheng YM, Korde AS et al. Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 2009; 40: 663-71.
    • (2009) Am. J. Respir. Cell Mol. Biol. , vol.40 , pp. 663-671
    • Liu, Q.H.1    Zheng, Y.M.2    Korde, A.S.3
  • 27
    • 84870879028 scopus 로고    scopus 로고
    • The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea
    • Pulkkinen V, Manson ML, Safholm J, Adner M, Dahlen SE. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am. J. Physiol. Lung Cell. Mol. Physiol. 2012; 303: L956-66.
    • (2012) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.303
    • Pulkkinen, V.1    Manson, M.L.2    Safholm, J.3    Adner, M.4    Dahlen, S.E.5
  • 28
    • 84884281253 scopus 로고    scopus 로고
    • PKC independent inhibition of voltage gated calcium channels by volatile anesthetics in freshly isolated vascular myocytes from the aorta
    • Fanchaouy M, Cubano L, Maldonado H, Bychkov R. PKC independent inhibition of voltage gated calcium channels by volatile anesthetics in freshly isolated vascular myocytes from the aorta. Cell Calcium 2013; 54: 257-65.
    • (2013) Cell Calcium , vol.54 , pp. 257-265
    • Fanchaouy, M.1    Cubano, L.2    Maldonado, H.3    Bychkov, R.4
  • 29
    • 60849108311 scopus 로고    scopus 로고
    • Site-specific regulation of CA(V)2.2 channels by protein kinase C isozymes betaII and epsilon
    • Rajagopal S, Fang H, Oronce CI et al. Site-specific regulation of CA(V)2.2 channels by protein kinase C isozymes betaII and epsilon. Neuroscience 2009; 159: 618-28.
    • (2009) Neuroscience , vol.159 , pp. 618-628
    • Rajagopal, S.1    Fang, H.2    Oronce, C.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.