Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8

American Journal of Pathology

Volumn 184, Issue 4, 2014, Pages 1030-1040

  Jia, Song Hui ^a   Parodo, Jean ^a   Charbonney, Emmanuel ^a,b   Tsang, Jennifer L Y ^a,b,c   Jia, Sang Yang ^a   Rotstein, Ori D ^a,b   Kapus, Andras ^a,b   Marshall, John C ^a,b,c  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE 3; CASPASE 8; GLUTAMIC ACID; GLUTATHIONE; HYDROGEN PEROXIDE; PHENYLALANINE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TYROSINE; CASP8 PROTEIN, HUMAN; OXIDIZING AGENT; PTPN6 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL INTERACTION; CELL STIMULATION; CONTROLLED STUDY; DEPHOSPHORYLATION; EPITHELIUM CELL; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE TRAUMA; MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; COCULTURE; IMMUNOPRECIPITATION; INFLAMMATION; INJURY; METABOLISM; NEUTROPHIL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

ADULT; APOPTOSIS; BLOTTING, WESTERN; CASPASE 8; CELLS, CULTURED; COCULTURE TECHNIQUES; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; MALE; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXIDANTS; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; TYROSINE; WOUNDS AND INJURIES;

EID: 84897856693     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.12.031     Document Type: Article

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