Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures

International Journal of Environmental Research and Public Health

Volumn 11, Issue 3, 2014, Pages 3156-3168

  Chen, Xueping ^a   Xu, Shisan ^b   Tan, Tianfeng ^a   Lee, Sin Ting ^a   Cheng, Shuk Han ^b   Lee, Fred Wang Fat ^c   Xu, Steven Jing Liang ^c   Ho, Kin Chung ^c  

^a Vitargent (International) Biotechnology Limited   (Hong Kong)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^c OPEN UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Enhanced estrogenic activity; Estrogenic activity; Estrogenic endocrine disruptor; Mixture effects; Phthalate; Toxicity

Indexed keywords

DI(N BUTYL) PHTHALATE; ENDOCRINE DISRUPTOR; ESTROGEN; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIISODECYL ESTER; PHTHALIC ACID DIISONONYL ESTER; UNCLASSIFIED DRUG;

ENDOCRINE DISRUPTOR; ESTROGENIC COMPOUND; HEALTH RISK; MORTALITY; PHTHALATE; RISK ASSESSMENT; TOXICITY; TOXICITY TEST;

ACUTE TOXICITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVELOPMENTAL TOXICITY; EMBRYO; EMBRYO MORTALITY; EMBRYOTOXICITY; HEALTH HAZARD; HEART EDEMA; HORMONE RESPONSE; LC 50; NECROSIS; NONHUMAN; ORYZIAS MELASTIGMA; SENSORY DYSFUNCTION; SYMPTOM; TRANSGENIC ANIMAL; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; DRUG EFFECTS; EMBRYO DEVELOPMENT; ORYZIAS; TOXICITY; TOXICITY TESTING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; ENDOCRINE DISRUPTORS; ORYZIAS; PHTHALIC ACIDS; TOXICITY TESTS, ACUTE; ZEBRAFISH;

EID: 84897842252     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph110303156     Document Type: Article

References (38)

1. Wan, H.T.; Leung, P.Y.; Zhao, Y.G.; Wei, X.; Wong, M.H.; Wong, C.K. Blood plasma concentrations of endocrine disrupting chemicals in Hong Kong populations. J. Hazard. Mater. 2013, 261, 763-769.
2. Xie, Z.; Ebinghaus, R.; Temme, C.; Lohmann, R.; Caba, A.; Ruck, W. Occurrence and air-sea exchange of phthalates in the Arctic. Environ. Sci. Tech. 2007, 41, 4555-4560.
3. Wang, W.X.; Zhang, Y.L.; Wang, S.L.; Fan, C.Q.; Xu, H. Distributions of phthalic esters carried by total suspended particulates in Nanjing, China. Environ. Monit. Assess. 2012, 184, 6789-6798.
4. Liu, H.; Liang, H.; Liang, Y.; Zhang, D.; Wang, C.; Cai, H.; Shvartsev, S.L. Distribution of phthalate esters in alluvial sediment: A case study at JiangHan Plain, Central China. Chemosphere 2010, 78, 382-388.
5. Kong, S.F.; Ji, Y.Q.; Liu, L.L.; Chen, L.; Zhao, X.Y.; Wang, J.J.; Bai, Z.P.; Sun, Z.R. Diversities of phthalate esters in suburban agricultural soils and wasteland soil appeared with urbanization in China. Environ. Pollut. 2012, 170, 161-168.
6. Fierens, T.; Van Holderbeke, M.; Willems, H.; De Henauw, S.; Sioen, I. Transfer of eight phthalates through the milk chain-A case study. Environ. Int. 2013, 51, 1-7.
7. Schecter, A.; Lorber, M.; Guo, Y.; Wu, Q.; Yun, S.H.; Kannan, K.; Hommel, M.; Imran, N.; Hynan, L.S.; Cheng, D.; Colacino, J.A.; Birnbaum, L.S. Phthalate concentrations and dietary exposure from food purchased in New York State. Environ. Health Perspect. 2013, 121, 473-494.
8. Liu, H.J.; Cao, J.; Shu, W.Q. Comparison of organic component and di-n-butyl phthalate between human milk and cow milk products (in Chinese). Zhonghua Yu Fang Yi Xue Za Zhi. 2011, 45, 53-56.
9. Zimmermann, S.; Gruber, L.; Schlummer, M.; Smolic, S.; Fromme, H. Determination of phthalic acid diesters in human milk at low ppb levels. Food Addit. Contam. Pt. A 2012, 29, 1780-1790.
10. Lin, S.; Ku, H.Y.; Su, P.H.; Chen, J.W.; Huang, P.C.; Angerer, J.; Wang, S.L. Phthalate exposure in pregnant women and their children in central Taiwan. Chemosphere 2011, 82, 947-955.
11. Hao, C.; Cheng, X.; Guo, J.; Xia, H.; Ma, X. Perinatal exposure to diethyl-hexyl-phthalate induces obesity in mice. Front. Biosci. 2013, 5, 725-733.
12. Pereira-Fernandes, A.; Demaegdt, H.; Vandermeiren, K.; Hectors, T.L.; Jorens, G.; Blust, R.; Vanparys, C. Evaluation of a screening system for obesogenic compounds: Screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect. PLoS One 2013, 8, doi:10.1371/journal.pone.0077481.
13. United States Environmental Protection Agency (USEPA). Electronic Code of Federal Regulations. Available online: http://www.ecfr.gov/cgi-bin/text-idx?c1/4ecfr&SID1/4b960051a53c9015d817718d71f1617b7&rgn1/4div5&view1/4text&node1/440,30.0.1.1.23&idno1/440#40:30.0.1.1.23.0.5.9.9. (accessed on 13 March 2014).
14. Andersen, H.R.; Andersson, A.M.; Arnold, S.F.; Autrup, H.; Barfoed, M.; Beresford, N.A.; Bjerregaard, P.; Christiansen, L.B.; Gissel, B.; Hummel, R.; et al. Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals. Environ. Health Perspect. 1999, 107, 89-108.
15. Ghisari, M.; Bonefeld-Jorgensen, E.C. Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions. Toxicol. Lett. 2009, 189, 67-77.
16. Ho, P.W.; Tse, Z.H.; Liu, H.F.; Lu, S.; Ho, J.W.; Kung, M.H.; Ramsden, D.B.; Ho, S.L. Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-o-methyltransferase (COMT) expression in an ELISA-based system. PLoS One 2013, 8, doi:10.1371/journal.pone.0074065.
17. Jobling, S.; Reynolds, T.; White, R.; Parker, M.G.; Sumpter, J.P. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 1995, 103, 582-587.
18. Parveen, M.; Inoue, A.; Ise, R.; Tanji, M.; Kiyama, R. Evaluation of estrogenic activity of phthalate esters by gene expression profiling using a focused microarray (estrarray®). Environ. Toxicol. Chem. 2008, 27, 1416-1425.
19. Veld, T.M.G.; Zawadzka, E.; van den Berg, J.H.; van der Saag, P.T.; Rietjens, I.M.; Murk, A.J. Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice. Chem. Biol. Interact. 2008, 174, 126-133.
20. Zacharewski, T.R.; Meek, M.D.; Clemons, J.H.; Wu, Z.F.; Fielden, M.R.; Matthews, J.B. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol. Sci. 1998, 46, 282-293.
21. Directive 2005/84/EC of the European Parliament and of the Council of 14 December 2005 Amending for the 22nd Time Council Directive 76/769/EEC on the Approximation of the Laws, Regulations and Administrative Provisions of the Member States Relating to Restrictions on the Marketing and Use of Certain Dangerous Substances and Preparations (Phthalates in Toys and Childcare Articles). Available online: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2005:344:0040:0043:en:PDF (accessed on 13 March 2014).
22. Cheng, S.H.; Wai, A.W.K.; So, C.H.; Wu, R.S.S. Cellular and molecular basis of cadmium-induced deformities in zebrafish embryos. Environ. Toxic. Chem. 2000, 19, 3024-3031.
23. Chen, X.; Kinoshita, M.; Hirata, T.; Yu, R.M.K.; Cheng, S.H. Transgenic marine medaka (Oryzias melastigma): A sensitive sentinel for estrogenic pollutants. Mol. Cell Toxicol. 2007, 3. Available online: http://astp.jst.go.jp/modules/search/DocumentDetail/1738-642x%2B%2540% 2B_3_4_Transgenic%2BMarine%2BMedaka%2B%2528Oryzias%2BMelastigma%2529%253A%2Ba%2BSensitive%2BSentinel%2Bfor%2BEstrogenic%2BPollutants_N%252FA (accessed on 13 March 2014).
24. Cheng, S.H.; Chen, X. Transgenic Fish and Uses Thereof. U.S. Patent Number US8395018 B2, 12 March 2013.
25. ISO/TS 20281:2006. Water quality-Guidance on statistical interpretation of ecotoxicity data.
26. European Food Safety Authority (EFSA). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to butylbenzylphthalate (BBP) for use in food contact materials. EFSA J. 2005, 241, 1-14.
27. European Food Safety Authority (EFSA). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to bis(2-ethylhexyl) phthalate (DEHP) for use in food contact materials. EFSA J. 2005, 243, 1-20.
28. European Food Safety Authority (EFSA). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isodecylphthalate (DIDP) for use in food contact materials. EFSA J. 2005, 245, 1-14.
29. European Food Safety Authority (EFSA). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isononylphthalate (DINP) for use in food contact materials. EFSA J. 2005, 244, 1-18.
30. European Food Safety Authority (EFSA). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to di-butylphthalate (DBP) for use in food contact materials. EFSA J. 2005, 242, 1-17.
31. Petersen, J.H.; Jensen, L.K. Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 2010, 27, 1608-1616.
32. Bi, X.; Pan, X.; Yuan, S.; Wang, Q. Plasticizer contamination in edible vegetable oil in a U.S. retail market. J. Agric. Food Chem. 2013, 61, 9502-9509.
33. Shen, O.; Du, G.; Sun, H.; Wu, W.; Jiang, Y.; Song, L.; Wang, X. Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. Toxicol. Lett. 2009, 191, 9-14.
34. Filipiak, E.; Walczak-Jedrzejowska, R.; Krupiński, M.; Oszukowska, E.; Marchlewska, K.; Długoński, J.; Kula, K.; Słowikowska-Hilczer, J. Di(n-butyl) phthalate has no effect on the rat prepubertal testis despite its estrogenic activity in vitro. Folia Histochem. Cytobiol. 2011, 49, 685-689.
35. Nomura, Y.; Mitsui, N.; Bhawal, U.K.; Sawajiri, M.; Tooi, O.; Takahashi, T.; Okazaki, M. Estrogenic activity of phthalate esters by in vitro VTG assay using primary-cultured Xenopus hepatocytes. Dent. Mater. J. 2006, 25, 533-537.
36. Harris, C.A.; Henttu, P.; Parker, M.G.; Sumpter, J.P. The estrogenic activity of phthalate esters in vitro. Environ. Health Perspect. 1997, 105, 808-811.
37. Zhang, Y.; Chen, B.; Ding, X.; Xie, X. Potential estrogenic activities of DBP, DEHP and their metabolites in immature rats using the uterotrophic assay. J. Environ. Occup. Med. 2005, 22, 11-13.
38. ECHA (European Chemical Agency). Evaluation of New Scientific Evidence Concerning the Restrictions Contained in Annex XVII to Regulation (EC) No. 1907/2006 (REACH). Available online: http://echa.europa.eu/documents/10162/a35fa99b-ed8f-4451-a4d5-f012e9ba69c7 (accessed on 13 March 2014).