Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: Pilot study

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 41, Issue 4, 2014, Pages 736-744

  Alawneh, Josef A ^a   Moustafa, Ramez R ^a,b   Marrapu, S Tulasi ^a   Jensen Kondering, Ulf ^a   Morris, Rhiannon S ^a   Jones, P Simon ^a   Aigbirhio, Franklin I ^a   Fryer, Tim D ^a   Carpenter, T Adrian ^a   Warburton, Elizabeth A ^a,c   Baron, Jean Claude ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b AIN SHAMS UNIVERSITY   (Egypt)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d CENTRE HOSPITALIER SAINTE ANNE   (France)

Author keywords

Acute stroke; Brain ischaemia; Imaging; Magnetic resonance imaging; Positron emission tomography

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; MISONIDAZOLE; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; ARTICLE; BLEEDING; BLOOD CLOT LYSIS; CASE REPORT; CEREBROVASCULAR ACCIDENT; COMPUTER ASSISTED TOMOGRAPHY; DIFFUSION WEIGHTED IMAGING; DROWSINESS; DYSARTHRIA; DYSPHASIA; FEMALE; FOLLOW UP; HEMIANOPIA; HEMIPARESIS; HEMIPLEGIA; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; MIDDLE CEREBRAL ARTERY OCCLUSION; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PERFUSION WEIGHTED IMAGING; PET SCANNER; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; PROSPECTIVE STUDY; SCINTIGRAPHY; VERY ELDERLY; ANALOGS AND DERIVATIVES; BRAIN ISCHEMIA; CASE CONTROL STUDY; COMPARATIVE STUDY; SCINTISCANNING; STROKE;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; CASE-CONTROL STUDIES; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; MISONIDAZOLE; PILOT PROJECTS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; STROKE;

EID: 84897826084     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-013-2581-x     Document Type: Article

References (35)

1. Muir KW, Buchan A, von Kummer R, Rother J, Baron JC. Imaging of acute stroke. Lancet Neurol. 2006;5:755-68. (Pubitemid 44205513)
2. Takasawa M, Moustafa RR, Baron JC. Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke. Stroke. 2008;39:1629-37.
3. Markus R, Donnan G, Kazui S, Read S, Reutens D. Penumbral topography in human stroke: methodology and validation of the 'Penumbragram'. Neuroimage. 2004;21:1252-9. (Pubitemid 38446556)
4. Markus R, Reutens DC, Kazui S, Read S, Wright P, Chambers BR, et al. Topography and temporal evolution of hypoxic viable tissue identified by 18F-fluoromisonidazole positron emission tomography in humans after ischemic stroke. Stroke. 2003;34:2646-52. (Pubitemid 37392759)
5. Markus R, Reutens DC, Kazui S, Read S, Wright P, Pearce DC, et al. Hypoxic tissue in ischaemic stroke: persistence and clinical consequences of spontaneous survival. Brain. 2004;127:1427-36. (Pubitemid 38745520)
6. Read SJ, Hirano T, Abbott DF, Markus R, Sachinidis JI, Tochon-Danguy HJ, et al. The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke. Ann Neurol. 2000;48:228-35. (Pubitemid 30617042)
7. Read SJ, Hirano T, Abbott DF, Sachinidis JI, Tochon-Danguy HJ, Chan JG, et al. Identifying hypoxic tissue after acute ischemic stroke using PET and 18F-fluoromisonidazole. Neurology. 1998;51:1617-21.
8. Falcao AL, Reutens DC, Markus R, Koga M, Read SJ, Tochon-Danguy H, et al. The resistance to ischemia of white and gray matter after stroke. Ann Neurol. 2004;56:695-701. doi:10.1002/ana.2026510.1002/ana.20265. (Pubitemid 39540750)
9. Sobesky J. Refining the mismatch concept in acute stroke: lessons learned from PET and MRI. J Cereb Blood Flow Metab. 2012;32: 1416-25. doi:10.1038/jcbfm.2012.54.
10. Signorini M, Paulesu E, Friston K, Perani D, Colleluori A, Lucignani G, et al. Rapid assessment of regional cerebral metabolic abnormalities in single subjects with quantitative and nonquantitative [18F]FDG PET: a clinical validation of statistical parametric mapping. Neuroimage. 1999;9:63-80. (Pubitemid 29369342)
11. Guadagno JV, Jones PS, Aigbirhio FI, Wang D, Fryer TD, Day DJ, et al. Selective neuronal loss in rescued penumbra relates to initial hypoperfusion. Brain. 2008;131:2666-78.
12. Alawneh JA, Jones PS, Mikkelsen IK, Cho TH, Siemonsen S, Mouridsen K, et al. Infarction of 'non-core-non-penumbral' tissue after stroke: multivariate modelling of clinical impact. Brain. 2011;134:1765-76. doi:10.1093/brain/awr100.
13. Wintermark M, Flanders AE, Velthuis B, Meuli R, van Leeuwen M, Goldsher D, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke. 2006;37: 979-85.
14. Piert M, Machulla HJ, Becker G, Aldinger P, Winter E, Bares R. Dependency of the [18F]fluoromisonidazole uptake on oxygen delivery and tissue oxygenation in the porcine liver. Nucl Med Biol. 2000;27:693-700. (Pubitemid 32063117)
15. Spratt NJ, Howells W, Donnan GA. The ischemic penumbra. In: Donnan GA, Baron JC, Sharp FS, Davies SM, editors. Imaging the penumbra: PET fluoromisonidazole. New York: Informa; 2007.
16. Furlan M, Marchal G, Viader F, Derlon JM, Baron JC. Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol. 1996;40:216-26. (Pubitemid 26274557)
17. Heiss WD, Huber M, Fink GR, Herholz K, Pietrzyk U, Wagner R, et al. Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab. 1992;12:193-203.
18. Guadagno JV, Warburton EA, Jones PS, Day DJ, Aigbirhio FI, Fryer TD, et al. How affected is oxygen metabolism in DWI lesions?: A combined acute stroke PET-MR study. Neurology. 2006;67:824-9. (Pubitemid 44394197)
19. Spratt NJ, Donnan GA, McLeod DD, Howells DW. 'Salvaged' stroke ischaemic penumbra shows significant injury: studies with the hypoxia tracer FMISO. J Cereb Blood Flow Metab. 2011;31:934-43.
20. Di Rocco RJ, Kuczynski BL, Pirro JP, Bauer A, Linder KE, Ramalingam K, et al. Imaging ischemic tissue at risk of infarction during stroke. J Cereb Blood Flow Metab. 1993;13: 755-62. (Pubitemid 23244744)
21. Rojas S, Herance JR, Abad S, Jimenez X, Pareto D, Ruiz A, et al. Evaluation of hypoxic tissue dynamics with 18F-FMISO PET in a rat model of permanent cerebral ischemia. Mol Imaging Biol. 2011;13: 558-64. doi:10.1007/s11307-010-0371-4.
22. Wise RJ, Rhodes CG, Gibbs JM, Hatazawa J, Palmer T, Frackowiak RS, et al. Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts. Ann Neurol. 1983;14:627-37. doi:10.1002/ana.410140605. (Pubitemid 14211608)
23. Price CJ, Wang D, Menon DK, Guadagno JV, Cleij M, Fryer T, et al. Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke. Stroke. 2006;37:1749-53. doi: 10.1161/01.STR.0000226980. 95389.0b. (Pubitemid 44297724)
24. Enzmann G, Mysiorek C, Gorina R, Cheng YJ, Ghavampour S, Hannocks MJ, et al. The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathol. 2013;125:395-412. doi:10. 1007/s00401-012-1076-3.
25. Casciari JJ, Graham MM, Rasey JS. A modeling approach for quantifying tumor hypoxia with [F-18]fluoromisonidazole PET time-activity data. Med Phys. 1995;22:1127-39.
26. Hong YT, Beech JS, Smith R, Baron JC, Fryer TD. Parametric mapping of [18F]fluoromisonidazole positron emission tomography using basis functions. J Cereb Blood Flow Metab. 2011;31:648-57. doi:10.1038/jcbfm.2010.141.
27. Bang OY, Buck BH, Saver JL, Alger JR, Yoon SR, Starkman S, et al. Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging. Ann Neurol. 2007;62:170-6. doi:10.1002/ana.21174. (Pubitemid 47546502)
28. Baron JC, Bousser MG, Rey A, Guillard A, Comar D, Castaigne P. Reversal of focal "misery-perfusion syndrome" by extra-intracranial arterial bypass in hemodynamic cerebral ischemia. A case study with 15O positron emission tomography. Stroke. 1981;12:454-9. (Pubitemid 11046690)
29. Powers WJ. Cerebral hemodynamics in ischemic cerebrovascular disease. Ann Neurol. 1991;29:231-40.
30. Yamauchi H, Higashi T, Kagawa S, Nishii R, Kudo T, Sugimoto K, et al. Is misery perfusion still a predictor of stroke in symptomatic major cerebral artery disease? Brain. 2012;135:2515-26. doi:10.1093/brain/aws131.
31. Spratt NJ, Donnan GA, Howells DW. Characterisation of the timing of binding of the hypoxia tracer FMISO after stroke. Brain Res. 2009;1288:135-42. doi:10.1016/j.brainres.2009.06.102.
32. Takasawa M, Beech JS, Fryer TD, Jones PS, Ahmed T, Smith R, et al. Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: a microPET study. Exp Neurol. 2011;229:251-8. doi:10.1016/j.expneurol.2011.02.005.
33. Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, et al. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET. Stroke. 2008;39:870-7. (Pubitemid 351619576)
34. Zaro-Weber O, Moeller-Hartmann W, Heiss WD, Sobesky J. MRI perfusion maps in acute stroke validated with 15O-water positron emission tomography. Stroke. 2010;41:443-9.
35. Hoffman JM, Rasey JS, Spence AM, Shaw DW, Krohn KA. Binding of the hypoxia tracer [3H]misonidazole in cerebral ischemia. Stroke. 1987;18:168-76. (Pubitemid 17016703)