Mulberry leaf extract attenuates oxidative stress-mediated testosterone depletion in streptozotocin-induced diabetic rats

Iranian Journal of Medical Sciences

Volumn 39, Issue 2, 2014, Pages 123-129

  Hajizadeh, Mohammad Reza ^a   Eftekhar, Ebrahim ^b   Zal, Fatemeh ^c   Jafarian, Aida ^d   Mostafavi Pour, Zohreh ^e  

^a RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HORMOZGAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes mellitus; Morus alba; Oxidative stress; Testosterone

Indexed keywords

CYTOCHROME P450; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; INSULIN; MALONALDEHYDE; MESSENGER RNA; MULBERRY EXTRACT; REGULATOR PROTEIN; STREPTOZOCIN; TESTOSTERONE;

ADULT; ANDROGEN DEFICIENCY; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEROIDOGENESIS; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TESTIS; TESTOSTERONE BLOOD LEVEL;

EID: 84897824141     PISSN: 02530716     EISSN: 17353688     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87:4-14. doi: 10.1016/j.diabres.2009.10.007. PubMed PMID: 19896746.
2. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 1999;48:1-9. doi: 10.2337/diabetes.48.1.1. PubMed PMID: 9892215.
3. Ballester J, Muñoz MC, Domínguez J, Rigau T, Guinovart JJ, Rodríguez-Gil JE. Insulindependent diabetes affects testicular function by FSH-and LH-linked mechanisms. J Androl. 2004;25:706-19. PubMed PMID: 15292100.
4. Koh PO. Streptozotocin-induced diabetes increases apoptosis through JNK phosphorylation and Bax activation in rat testes. J Vet Med Sci. 2007;69: 969-71. doi: 10.1292/jvms.69.969. PubMed PMID: 17917385.
5. Ricci G, Catizone A, Esposito R, Pisanti FA, Vietri MT, Galdieri M. Diabetic rat testes: morphological and functional alterations. Andrologia. 2009;41:361-8. doi: 10.1111/j.1439-0272.2009.00937.x. PubMed PMID: 19891634.
6. Quinn PG, Payne AH. Oxygen-mediated damage of microsomal cytochrome P-450 enzymes in cultured leydig cells. Role in steroidogenic desensitization. J Biol Chem. 1984;259:4130-5. PubMed PMID: 6584429.
7. Lavoie HA, King SR. Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B. Exp Biol Med (Maywood). 2009;234:880-907. doi: 10.3181/0903-MR-97. PubMed PMID: 19491374.
8. Diemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology. 2003;144:2882-91. doi: 10.1210/en.2002-0090. PubMed PMID: 12810543.
9. Ramaa CS, Shirode AR, Mundada AS, Kadam VJ. Nutraceuticals-an emerging era in the treatment and prevention of cardiovascular diseases. Curr Pharm Biotechnol. 2006; 7:15-23. doi: 10.2174/138920106775789647. PubMed PMID: 16472130.
10. Musabayane CT, Bwititi PT, Ojewole JA. Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats. Methods Find Exp Clin Pharmacol. 2006; 28:223-8. doi: 10.1358/mf.2006.28.4.990202. PubMed PMID: 16801983.
11. Naowaboot J, Pannangpetch P, Kukongviriyapan V, Kongyingyoes B, Kukongviriyapan U. Antihyperglycemic, antioxidant and antiglycation activities of mulberry leaf extract in streptozotocin-induced chronic diabetic rats. Plant Foods Hum Nutr. 2009;64:116-21. doi: 10.1007/s11130-009-0112-5. PubMed PMID: 19434497.
12. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54. doi: 10.1006/abio.1976.9999. PubMed PMID: 942051.
13. Hagar HH, El Etter E, Arafa M. Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. Clin Exp Pharmacol Physiol. 2006;33:189-96. doi: 10.1111/j.1440-1681.2006.04345.x. PubMed PMID: 16487261.
14. Eftekhar E, Hajirahimkhan A, Taghizadeh Afshari A, Nourooz-Zadeh J. Plasma glutathione peroxidase activity in kidney recipients with and without adverse outcome. Ren Fail. 2012;34:628-33. doi: 10.3109/0886022X.2012.669321. PubMed PMID: 22563921.
15. Carlberg I, Mannervik B. Glutathione reductase. Method Enzymol. 1985;113:484-90. doi: 10.1016/S0076-6879(85)13062-4. PubMed PMID: 3003504.
16. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996;239:70-6. doi: 10.1006/ abio.1996.0292. PubMed PMID: 8660627.
17. Kim JW, Kim SU, Lee HS, Kim I, Ahn MY, Ryu KS. Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase high-performance liquid chromatography. J Chromatogr A. 2003;1002:93-9. doi: 10.1016/S0021-9673(03)00728-3. PubMed PMID: 12885082.
18. Singab AN, El-Beshbishy HA, Yonekawa M, Nomura T, Fukai T. Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats. J Ethnopharmacol. 2005;100:333-8. doi: 10.1016/j.jep.2005.03.013. PubMed PMID: 15885940.
19. Hussain Z, Waheed A, Qureshi RA, Burdi DK, Verspohl EJ, Khan N, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res. 2004;18:73-7. doi: 10.1002/ptr.1372. PubMed PMID: 14750205.
20. Mohasseb M, Ebied S, Yehia MA, Hussein N. Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats. J Physiol Biochem. 2011;67:185-94. doi: 10.1007/s13105-010-0062-2. PubMed PMID: 21184211.
21. Soman S, Rauf AA, Indira M, Rajamanickam C. Antioxidant and antiglycative potential of ethyl acetate fraction of Psidium guajava leaf extract in streptozotocin-induced diabetic rats. Plant Food Hum Nutr. 2010;65:386-91. doi: 10.1007/s11130-010-0198-9. PubMed PMID: 21120613.
22. Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M, et al. Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr. 2005; 135:729-34. PubMed PMID: 15795425.
23. Unlüçerçi Y, Bekpinar S, Koçak H. Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats. Arch Biochem Biophys. 2000; 379: 217-20. PubMed PMID: 10898937.
24. Shrilatha B; Muralidhara. Occurrence of oxidative impairments, response of antioxidant defences and associated biochemical perturbations in male reproductive milieu in the Streptozotocin-diabetic rat. Int J Androl. 2007; 30: 508-18. doi: 10.1111/j.1365-2605.2007.00748.x. PubMed PMID: 17573857.
25. Navarro-Casado L, Juncos-Tobarra MA, Cháfer-Rudilla M, de Onzoño LÍ, Blázquez-Cabrera JA, Miralles-García JM. Effect of experimental diabetes and STZ on male fertility capacity. Study in rats. J Androl. 2010; 31: 584-92. doi: 10.2164/jandrol.108.007260. PubMed PMID: 20203339.
26. Georgiou M, Perkins LM, Payne AH. Steroid synthesis-dependent, oxygen-mediated damage of mitochondrial and microsomal cytochrome P-450 enzymes in rat Leydig cell cultures. Endocrinology. 1987;121:1390-9. doi: 10.1210/endo-121-4-1390. PubMed PMID: 2820696.
27. Tsai SC, Lu CC, Lin CS, Wang PS. Antisteroidogenic actions of hydrogen peroxide on rat Leydig cells. J Cell Biochem. 2003,90:1276-86. doi: 10.1002/jcb.10738. PubMed PMID: 14635199.
28. Murugesan P, Kanagaraj P, Yuvaraj S, Balasubramanian K, Aruldhas MM, Arunakaran J. The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats. Reprod Toxicol. 2005;20:117-26. doi: 10.1016/j.reprotox.2004.11.011. PubMed PMID: 15808795.