Effects of prostacyclin on the early inflammatory response in patients with traumatic brain injury-a randomised clinical study

SpringerPlus

Volumn 3, Issue 1, 2014, Pages

  Wahlström, Marie Rodling ^a   Olivecrona, Magnus ^a   Ahlm, Clas ^a   Bengtsson, Anders ^b   Koskinen, Lars Owe D ^a   Naredi, Silvana ^a   Hultin, Magnus ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b SAHLGRENSKA ACADEMY AT UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Asymmetric dimethylarginine; Cytokines; Epoprostenol; Systemic inflammatory response; Traumatic brain injury

Indexed keywords

EID: 84897795232     PISSN: None     EISSN: 21931801     Source Type: Journal    
DOI: 10.1186/2193-1801-3-98     Document Type: Article

References (31)

1. Andersson J, Sjöström LG, Karlsson M, Wiklund U, Hultin M, Karpe F et al (2010) Dysregulation of subcutaneous adipose tissue blood flow in overweight postmenopausal women. Menopause 17:365-371.
2. Baker SP, O'Neill B, Haddon W, Long WB (1974) The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma 14:187-196.
3. Böger RH (2003) Association of asymmetric dimethylarginine and endothelial dysfunction. Clin Chem Lab Med 41:1467-1472.
4. Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354:610-621.
5. Chin KM, Channick RN, de Lemos JA, Kim NH, Torres F, Rubin LJ (2009) Hemodynamics and epoprostenol use are associated with thrombocytopenia in pulmonary arterial hypertension. Chest 135:130-136.
6. Du Clos TW (2000) Function of C-reactive protein. Ann Med 32:274-278.
7. Grände PO (2006) The "Lund Concept" for the treatment of severe head trauma-physiological principles and clinical application. Intensive Care Med 32:1475-1484.
8. Grände PO, Möller AD, Nordström CH, Ungerstedt U (2000) Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements. Acta Anaesthesiol Scand 44:886-894.
9. Holmin S, Söderlund J, Biberfeld P, Mathiesen T (1998) Intracerebral inflammation after human brain contusion. Neurosurgery 42:291-298, discussion 298-9.
10. Jawa RS, Anillo S, Huntoon K, Baumann H, Kulaylat M (2011) Interleukin-6 in surgery, trauma, and critical care part II: clinical implications. J Intensive Care Med 26:73-87.
11. Jones G, Hurley JV (1984) The effect of prostacyclin on the adhesion of leucocytes to injured vascular endothelium. J Pathol 142:51-59.
12. Jungner M, Bentzer P, Grände PO (2009) Prostacyclin reduces elevation of intracranial pressure and plasma volume loss in lipopolysaccharide-induced meningitis in the cat. J Trauma 67:1345-1351.
13. Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818-829.
14. Lawson C, Wolf S (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep 61:22-32.
15. Lenz A, Franklin GA, Cheadle WG (2007) Systemic inflammation after trauma. Injury 38:1336-1345.
16. Lu J, Goh SJ, Tng PY, Deng YY, Ling EA, Moochhala S (2009) Systemic inflammatory response following acute traumatic brain injury. Front Biosci 14:3795-3813.
17. Moncada S, Gryglewski R, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663-665.
18. Naredi S, Olivecrona M, Lindgren C, Ostlund AL, Grände PO, Koskinen LO (2001) An outcome study of severe traumatic head injury using the "Lund therapy" with low-dose prostacyclin. Acta Anaesthesiol Scand 45:402-406.
19. Neunaber C, Zeckey C, Andruszkow H, Frink M, Mommsen P, Krettek C et al (2011) Immunomodulation in polytrauma and polymicrobial sepsis-where do we stand? Recent Pat Inflamm Allergy Drug Discov 5:17-25.
20. Ohta S, Nakamuta M, Fukushima M, Kohjima M, Kotoh K, Enjoji M et al (2005) Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates concanavalin A-induced liver injury in mice. Liver Int 25:1061-1068.
21. Olivecrona M, Rodling-Wahlström M, Naredi S, Koskinen LO (2009) Prostacyclin treatment in severe traumatic brain injury: a microdialysis and outcome study. J Neurotrauma 26:1251-1262.
22. Orfeo T, Doherty JM, Adey G, Penar PL, Shatos MA (1994) Sublethal percussion trauma in vitro causes a persisting derangement in the nonthrombogenic properties of brain endothelial cells. J Trauma 37:347-357.
23. Roberts I, Yates D, Sandercock P, Farrell B, Wasserberg J, Lomas G et al (2004) Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 364:1321-1328.
24. Scheeren T, Radermacher P (1997) Prostacyclin (PGI2): new aspects of an old substance in the treatment of critically ill patients. Intensive Care Med 23:146-158.
25. Siekmeier R, Grammer T, März W (2008) Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function. J Cardiovasc Pharmacol Ther 13:279-297.
26. Stahel PF, Smith WR, Moore EE (2007) Role of biological modifiers regulating the immune response after trauma. Injury 38:1409-1422.
27. Stanisic M, Aasen AO, Pripp AH, Lindegaard KF, Ramm-Pettersen J, Lyngstadaas SP et al (2012) Local and systemic pro-inflammatory and anti-inflammatory cytokine patterns in patients with chronic subdural hematoma: a prospective study. Inflamm Res 61:845-852.
28. Teasdale G, Jennett B (1974) Assessment of coma and impaired consciousness. A practical scale. Lancet 2:81-84.
29. Teasdale G, Jennett B (1976) Assessment and prognosis of coma after head injury. Acta Neurochir (Wien) 34:45-55.
30. Teerlink T, Nijveldt RJ, de Jong S, van Leeuwen PA (2002) Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography. Anal Biochem 303:131-137.
31. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707-710.