Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements

Acta Anaesthesiologica Scandinavica

Volumn 44, Issue 7, 2000, Pages 886-894

  Grände, Per Olof ^b   Moller A D ^c   Nordstrom C H ^c   Ungerstedt, U ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c NONE

Author keywords

Brain contusion; Glucose; Glycerol; Head injury; Jugular venous bulb saturation; Lactate; Microcirculation; Microdialysis; Prostacyclin; Py ruvate

Indexed keywords

GLUCOSE; GLYCEROL; LACTIC ACID; OXYGEN; PROSTACYCLIN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BRAIN INJURY; BRAIN LEVEL; BRAIN MICROCIRCULATION; BRAIN OXYGEN CONSUMPTION; BRAIN PERFUSION; BRAIN PROTECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; MALE; MICRODIALYSIS; PRIORITY JOURNAL;

ADULT; AGED; ANOXIA; BIOLOGICAL MARKERS; BRAIN INJURIES; ENERGY METABOLISM; EPOPROSTENOL; FEMALE; HUMANS; JUGULAR VEINS; LACTIC ACID; MALE; MICRODIALYSIS; MIDDLE AGED; OXYGEN; PLATELET AGGREGATION INHIBITORS; PYRUVIC ACID;

EID: 0033942299     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2000.440718.x     Document Type: Article

References (44)

1. 1. McIntosh TK, Smith DH, Garde E. Therapeutic approaches for the prevention of secondary brain injury. Eur J Anaesthesiol 1996: 13: 291-309.
2. 2. Schröder ML, Muizelaar JP, Bullock MR, Salvant JB, Povlishock JT. Focal ischemia due to traumatic contusions documented by stable xenon-CT and ultrastructural studies. J Neurosurg 1995: 82: 966-971.
3. 3. Maeda T, Katayama Y, Kawamata T, Aoyama N, Mori T. Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. Acta Neurochir 1997: 70 (Suppl): 102-105.
4. 4. McLaughlin MR, Marion DW. Cerebral blood flow and vaso-responsivity within and around cerebral contusions. J Neurosurg 1996: 85: 871-876.
5. 5. Wahl M, Schilling L, Unterberg A, Baethmann A. Mediators of vascular and parenchymal mechanisms in secondary brain damage. Acta Neurochir 1993: 57 (Suppl): 64-72.
6. 6. Holmin S, Mathiesen T, Shetye J, Biberfeld P. Intracerebral inflammatory response to experimental brain contusion. Acta Neurochir (Wien) 1995: 132: 110-119.
7. 7. Maas AIR. Pathophysiology, monitoring and treatment of severe head injury. In: Vincent JL (ed). Yearbook of Intensive Care and Emergency Medicine. Berlin, Heidelberg: Springer Verlag, 1993: 555-578.
8. 8. McIntosh TK, Juhler M, Wieloch T. Novel pharmacologic strategies in the treatment of experimental brain injury. J Neurotrauma 1998: 15: 731-769.
9. 9. Siesjö BK, Siesjö P. Mechanisms of secondary brain injury. Eur J Anaesthesiol 1996: 13: 247-268.
10. 10. del Zoppo GJ. Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 1994: 6: 47-96.
11. 11. Dietrich WD, Alonso O, Busto R, Prado R, Dewanjee S, Dewanjee MK et al. Widespread hemodynamic depression and focal platelet accumulation after fluid percussion brain injury: a double-label autoradiographic study in rats. J Cereb Blood Flow Metab 1996: 16: 481-489.
12. 12. Kretschmar K, Engelhardt T. Swelling of capillary endothelial cells contributes to traumatic hemorrhagic shock-induced microvascular injury: a morphologic and morphometric analysis. Int J Microcirc 1994: 4: 45-49.
13. 13. Moncada S, Gryglewski R, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976: 263: 663-665.
14. 14. Jones G, Hurley JV. The effects of prostacyclin on the adhesion of leukocytes to injured vascular endothelium. J Pathol 1984: 142: 51-59.
15. 2) on platelet behaviour, thrombus formation in vivo and bleeding time. Thromb Haemost 1979: 41: 425-435.
16. 16. Baldus B, Mueller B. Iloprost improves the filtrability of stressed rabbit erythrocytes. Clin Hemorheol 1985: 5: 742A.
17. 2) on cerebral blood flow in man. J Neurol Neurosurg Psychiatry 1982: 45: 1033-1036.
18. 18. Möller AD, Grande PO. Low-dose prostacyclin has potent capillary permeability reducing effects in cat skeletal muscle in vivo. Am J Physiol 1997: 273: H200-H207.
19. 19. Pluta R. Complete cerebral ischaemia, prostacyclin deficiency, and theurapeutic possibilities. Acta Neurochir 1994: 60 (Suppl): 303-306.
20. 2): new aspects of an old substance in the treatment of critically ill patients. Intensive Care Med 1997: 23: 146-158.
21. 21. Orfeo T, Doherty JM, Adey G, Penar PL, Shatos MA. Sublethal percussion trauma in vitro causes a persisting derangement in the nonthrombogenic properties of brain endothelial cells. J Trauma 1994: 37: 347-357.
22. 22. Olson DM, Tanswell AK. Effects of oxygen, calcium, ionophore and arachidonic acid on prostaglandin production by monolayer cultures of mixed cells and endothelial cells from rat fetal lungs. Exp Lung Res 1997: 12: 207-221.
23. 23. Ungerstedt U. Microdialysis - principles and application for studies in animals and man. J Intern Med 1991: 230: 365-373.
24. 24. Ungerstedt U, Bäckström T, Hallström Å, Grande PO, Mellergård P, Nordström CH. Microdialysis in normal and injured human brain. In: Kinney JM, Tucker HN (eds). Physiology, stress, and malnutrition: Functional correlates, nutritional intervention. Philadelphia, New York: Lippincott-Raven, 1997: 361-373.
25. 25. Landholt H, Langemann H. Cerebral microdialysis as a diagnostic tool in acute brain injury. Eur J Anaesthesiol 1996: 13: 269-278.
26. 26. Grände PO, Asgeirsson B, Nordström CH. Physiologic principles for volume regulation of a tissue enclosed in a rigid shell with application to the injured brain. J Trauma 1997: 42: 23-31.
27. 27. Eker C, Asgeirsson B, Grande PO, Schalén W, Nordström CH. Improved outcome after severe head injury with a new therapy based on principles for brain volume regulation and preserved microcirculation. Crit Care Med 1998: 11: 1881-1886.
28. 28. Dearden NM, Midgley S. Technical considerations in continuous jugular venous oxygen saturation measurement. Acta Neurochir 1993: 59 (Suppl): 91-97.
29. 29. Siesjö BK. Brain energy metabolism. New York: John Wiley & Sons Ltd, 1978.
30. 30. Harada M, Okuda C, Sawa T, Murakami T. Cerebral extracellular glucose and lactate concentrations during and after moderate hypoxia in glucose-and saline-infused rats. Anesthesiology 1992: 77: 728-734.
31. 31. Persson L, Valtysson J, Enblad P, Wärme PE, Cesarini K, Lewén A, Hillered L. Neurochemical monitoring using intracerebral microdialysis in patients with subarachnoid hemorrhage. J Neurosurg 1996: 84: 606-616.
32. 32. Vary TC, O'Neal P, Cooney RN, Maish G, Shumate M. Chronic infusion of interleukin-1 induces hyperlactatemia and altered regulation of lactate metabolism in skeletal muscle. J Parenter Enteral Nutr 1999: 23: 213-217.
33. 33. Vary TC, Hazen SA, Maish G, Cooney RN. TNF binding protein prevents hyperlactatemia and inactivation of PDH complex in skeletal muscle during sepsis. J Surg Res 1998: 80: 44-51.
34. 34. Hotchkiss RS, Karl IE. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 1992: 267: 1503-1510.
35. 35. Bergsneider M, Hovda DA, Shalmon E, Kelly DA, Vespa PM, Martin A et al. Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. Neurosurg 1997: 86: 241-251.
36. 36. Mizock BA. Significance of hyperlactatemia without acidosis during hypermetabolic stress. Crit Care Med 1997: 25: 1780-1781.
37. 37. Maggs DG, Borg WP, Sherwin RS. Microdialysis techniques in the study of brain and skeletal muscle. Diabetologica 1997: 40: S75-S82.
38. 38. Hickner RC, Rosdahl H, Borg I, Ungerstedt U, Jorfeldt L, Henriksson J. The ethanol technique of monitoring local blood flow changes in rat skeletal muscle: implications for microdialysis. Acta Physiol Scand 1992: 146: 87-97.
39. 39. Marklund S, Salci K, Lewén A, Hillered L. Glycerol as a marker for post-traumatic membrane phospohlipid degradation in rat brain. Neuroreport 1997: 8: 1457-1461.
40. 40. Hillered L, Valtysson J, Enblad P, Persson L. Interstitial glycerol as a marker for phospholipid degradation in the acutely injured human brain. J Neurol Neurosurg Psychiatry 1998: 64: 486-491.
41. 41. Gryglewski RJ, Nowak SN, Kostka-Trabka E, Kusmiderski J, Deminska-Kiec A, Bieron K et al. Treatment of ischaemic stroke with prostacyclin. Stroke 1983: 14: 197-202.
42. 42. Davies MG, Hagen PO. The vascular endothelium. A new horizon. Ann Surg 1993: 218: 593-609.
43. 43. Katusic ZS, Vanhoutte PM. Superoxide anion is an endothelium-derived contracting factor. Am J Physiol 1989: 6: H33-H37.
44. 2) on platelet adhesion to rabbit arterial endothelium. Prostaglandins 1978: 16: 17-22.