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Journal of the American Chemical Society

Volumn 136, Issue 9, 2014, Pages 3370-3373

An Fc domain protein-small molecule conjugate as an enhanced immunomodulator

(17) Chiang, Meng Jung a Holbert, Marc A a Kalin, Jay H a Ahn, Young Hoon a Giddens, John b Amin, Mohammed N b Taylor, Martin S a Collins, Samuel L a Chan Li, Yee a Waickman, Adam a Hsiao, Po Yuan a Bolduc, David a Leahy, Daniel J a Horton, Maureen R a Wang, Lai Xi b Powell, Jonathan D a Cole, Philip A a

a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (United States)

b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULES;

DRUG TARGETS; EXPRESSED PROTEIN LIGATION; FC-RECEPTORS; IMMUNO MODULATORS; MOUSE MODELS; SECRETED PROTEIN; SMALL MOLECULES; THERAPEUTIC AGENTS;

PROTEINS;

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); CYTOCHROME C; FC PROTEIN; FC RECEPTOR; IMMUNOMODULATING AGENT; INTERLEUKIN 2; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGLYCOSYLATION; DRUG CONJUGATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL PERMEATION CHROMATOGRAPHY; GLYCOSYLATION; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PNEUMONIA; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR OCCUPANCY; SPLEEN CELL; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

ADENOSINE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; IMMUNOCONJUGATES; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOLOGIC FACTORS; MICE; MODELS, MOLECULAR; PHENETHYLAMINES; PROTEIN CONFORMATION;

EID: 84897714566 PISSN: 00027863 EISSN: 15205126 Source Type: Journal
DOI: 10.1021/ja5006674 Document Type: Article

Times cited : (15)

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