메뉴 건너뛰기




Volumn 5, Issue FEB, 2014, Pages

TNF receptor-associated factor 1 is a major target of soluble TWEAK

Author keywords

CD40; NF B; TNF; TRAF1; TWEAK

Indexed keywords

CD40 ANTIGEN; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1;

EID: 84897707300     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00063     Document Type: Article
Times cited : (12)

References (45)
  • 1
    • 80054865852 scopus 로고    scopus 로고
    • TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses
    • doi: 10.1111/j.1600-065X.2011.01054.x
    • Burkly LC, Michaelson JS, Zheng TS. TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses. Immunol Rev (2011) 244:99-114. doi: 10.1111/j.1600-065X.2011.01054.x.
    • (2011) Immunol Rev , vol.244 , pp. 99-114
    • Burkly, L.C.1    Michaelson, J.S.2    Zheng, T.S.3
  • 2
    • 84885115695 scopus 로고    scopus 로고
    • The TWEAK-Fn14 system as a potential drug target
    • doi:10.1111/bph.12337
    • Wajant H. The TWEAK-Fn14 system as a potential drug target. Br J Pharmacol (2013) 170:748-64. doi:10.1111/bph.12337.
    • (2013) Br J Pharmacol , vol.170 , pp. 748-764
    • Wajant, H.1
  • 3
    • 0141815764 scopus 로고    scopus 로고
    • TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation
    • doi:10.1074/jbc.M304266200
    • Saitoh T, Nakayama M, Nakano H, Yagita H, Yamamoto N, Yamaoka S. TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J Biol Chem (2003) 278:36005-12. doi:10.1074/jbc.M304266200.
    • (2003) J Biol Chem , vol.278 , pp. 36005-36012
    • Saitoh, T.1    Nakayama, M.2    Nakano, H.3    Yagita, H.4    Yamamoto, N.5    Yamaoka, S.6
  • 4
    • 84858627919 scopus 로고    scopus 로고
    • Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors
    • doi:10.1126/scisignal.2001878
    • Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, et al. Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors. Sci Signal (2012) 5(216):ra22. doi:10.1126/scisignal.2001878.
    • (2012) Sci Signal , vol.5 , Issue.216
    • Varfolomeev, E.1    Goncharov, T.2    Maecker, H.3    Zobel, K.4    Kömüves, L.G.5    Deshayes, K.6
  • 5
    • 18244380611 scopus 로고    scopus 로고
    • A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis
    • doi:10.1016/S1074-7613(01)00232-1
    • Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, et al. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity (2001) 15:837-46. doi:10.1016/S1074-7613(01)00232-1.
    • (2001) Immunity , vol.15 , pp. 837-846
    • Wiley, S.R.1    Cassiano, L.2    Lofton, T.3    Davis-Smith, T.4    Winkles, J.A.5    Lindner, V.6
  • 6
    • 0038242506 scopus 로고    scopus 로고
    • TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-kappa B through TNF receptor-associated factors
    • doi:10.1016/S0006-291X(03)00852-0
    • Han S, Yoon K, Lee K, Kim K, Jang H, Lee NK, et al. TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-kappa B through TNF receptor-associated factors. Biochem Biophys Res Commun (2003) 305:789-96. doi:10.1016/S0006-291X(03)00852-0.
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 789-796
    • Han, S.1    Yoon, K.2    Lee, K.3    Kim, K.4    Jang, H.5    Lee, N.K.6
  • 7
    • 0038708366 scopus 로고    scopus 로고
    • The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
    • doi:10.1042/BJ20021730
    • Brown SA, Richards CM, Hanscom HN, Feng SL, Winkles JA. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Biochem J (2003) 371:395-403. doi:10.1042/BJ20021730.
    • (2003) Biochem J , vol.371 , pp. 395-403
    • Brown, S.A.1    Richards, C.M.2    Hanscom, H.N.3    Feng, S.L.4    Winkles, J.A.5
  • 8
    • 61449148439 scopus 로고    scopus 로고
    • TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1
    • doi:10.4049/jimmunol.0803357
    • Kumar M, Makonchuk DY, Li H, Mittal A, Kumar A. TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1. J Immunol (2009) 182:2439-48. doi:10.4049/jimmunol.0803357.
    • (2009) J Immunol , vol.182 , pp. 2439-2448
    • Kumar, M.1    Makonchuk, D.Y.2    Li, H.3    Mittal, A.4    Kumar, A.5
  • 9
    • 84881249513 scopus 로고    scopus 로고
    • The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2
    • doi:10.1074/jbc.M113.468686
    • Fortin Ensign SP, Mathews IT, Eschbacher JM, Loftus JC, Symons MH, Tran NL. The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2. J Biol Chem (2013) 288:21887-2897. doi:10.1074/jbc.M113.468686.
    • (2013) J Biol Chem , vol.288 , pp. 21887-22897
    • Fortin Ensign, S.P.1    Mathews, I.T.2    Eschbacher, J.M.3    Loftus, J.C.4    Symons, M.H.5    Tran, N.L.6
  • 10
    • 33750300516 scopus 로고    scopus 로고
    • Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome
    • doi:10.1158/0008-5472.CAN-06-0418
    • Tran NL, Mcdonough WS, Savitch BA, Fortin SP, Winkles JA, Symons M, et al. Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Res (2006) 66:9535-42. doi:10.1158/0008-5472.CAN-06-0418.
    • (2006) Cancer Res , vol.66 , pp. 9535-9542
    • Tran, N.L.1    Mcdonough, W.S.2    Savitch, B.A.3    Fortin, S.P.4    Winkles, J.A.5    Symons, M.6
  • 11
    • 84864011846 scopus 로고    scopus 로고
    • Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells
    • doi:10.1158/1541-7786.MCR-11-0616
    • Fortin SP, Ennis MJ, Schumacher CA, Zylstra-Diegel CR, Williams BO, Ross JT, et al. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Mol Cancer Res (2012) 10:958-68. doi:10.1158/1541-7786.MCR-11-0616.
    • (2012) Mol Cancer Res , vol.10 , pp. 958-968
    • Fortin, S.P.1    Ennis, M.J.2    Schumacher, C.A.3    Zylstra-Diegel, C.R.4    Williams, B.O.5    Ross, J.T.6
  • 12
    • 0031465594 scopus 로고    scopus 로고
    • TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis
    • doi:10.1074/jbc.272.51.32401
    • Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem (1997) 272:32401-10. doi:10.1074/jbc.272.51.32401.
    • (1997) J Biol Chem , vol.272 , pp. 32401-32410
    • Chicheportiche, Y.1    Bourdon, P.R.2    Xu, H.3    Hsu, Y.M.4    Scott, H.5    Hession, C.6
  • 13
    • 0034613732 scopus 로고    scopus 로고
    • Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity
    • doi:10.1084/jem.192.9.1373
    • Nakayama M, Kayagaki N, Yamaguchi N, Okumura K, Yagita H. Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity. J Exp Med (2000) 192:1373-80. doi:10.1084/jem.192.9.1373.
    • (2000) J Exp Med , vol.192 , pp. 1373-1380
    • Nakayama, M.1    Kayagaki, N.2    Yamaguchi, N.3    Okumura, K.4    Yagita, H.5
  • 14
    • 77952892382 scopus 로고    scopus 로고
    • Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway
    • doi:10.1074/jbc.M110.131979
    • Brown SA, Ghosh A, Winkles JA. Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway. J Biol Chem (2010) 285:17432-41. doi:10.1074/jbc.M110.131979.
    • (2010) J Biol Chem , vol.285 , pp. 17432-17441
    • Brown, S.A.1    Ghosh, A.2    Winkles, J.A.3
  • 15
    • 77956406117 scopus 로고    scopus 로고
    • Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway
    • doi:10.4049/jimmunol.0903555
    • Roos C, Wicovsky A, Müller N, Salzmann S, Rosenthal T, Kalthoff H, et al. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. J Immunol (2010) 185:1593-605. doi:10.4049/jimmunol.0903555.
    • (2010) J Immunol , vol.185 , pp. 1593-1605
    • Roos, C.1    Wicovsky, A.2    Müller, N.3    Salzmann, S.4    Rosenthal, T.5    Kalthoff, H.6
  • 16
    • 47549097367 scopus 로고    scopus 로고
    • TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα
    • doi:10.1083/jcb.200801010
    • Vince JE, Chau D, Callus B, Wong WWL, Hawkins CJ, Schneider P, et al. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα. J Cell Biol (2008) 182:171-84. doi:10.1083/jcb.200801010.
    • (2008) J Cell Biol , vol.182 , pp. 171-184
    • Vince, J.E.1    Chau, D.2    Callus, B.3    Wong, W.W.L.4    Hawkins, C.J.5    Schneider, P.6
  • 17
    • 70350007940 scopus 로고    scopus 로고
    • TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling
    • doi:10.1038/cdd.2009.80)
    • Wicovsky A, Salzmann S, Roos C, Ehrenschwender M, Rosenthal T, Siegmund D, et al. TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling. Cell Death Differ (2009) 16:1445-59. doi:10.1038/cdd.2009.80).
    • (2009) Cell Death Differ , vol.16 , pp. 1445-1459
    • Wicovsky, A.1    Salzmann, S.2    Roos, C.3    Ehrenschwender, M.4    Rosenthal, T.5    Siegmund, D.6
  • 18
    • 83955161650 scopus 로고    scopus 로고
    • Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes
    • doi:10.1016/j.cellimm.2011.09.004
    • Yamana J, Morand EF, Manabu T, Sunahori K, Takasugi K, Makino H, et al. Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes. Cell Immunol (2012) 272:293-8. doi:10.1016/j.cellimm.2011.09.004.
    • (2012) Cell Immunol , vol.272 , pp. 293-298
    • Yamana, J.1    Morand, E.F.2    Manabu, T.3    Sunahori, K.4    Takasugi, K.5    Makino, H.6
  • 19
    • 84881511197 scopus 로고    scopus 로고
    • The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNFα
    • doi:10.1210/jc.2012-4177
    • Maymó-Masip E, Fernández-Veledo S, Garcia España A, Vázquez-Carballo A, Tinahones FJ, et al. The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNFα. J Clin Endocrinol Metab (2013) 98:1323-33. doi:10.1210/jc.2012-4177.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1323-1333
    • Maymó-Masip, E.1    Fernández-Veledo, S.2    Garcia España, A.3    Vázquez-Carballo, A.4    Tinahones, F.J.5
  • 20
    • 84883401846 scopus 로고    scopus 로고
    • TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes
    • doi:10.4049/jimmunol.1202899
    • Salzmann S, Lang I, Rosenthal A, Schäfer V, Weisenberger D, Carmona Arana JA, et al. TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes. J Immunol (2013) 191:2308-18. doi:10.4049/jimmunol.1202899.
    • (2013) J Immunol , vol.191 , pp. 2308-2318
    • Salzmann, S.1    Lang, I.2    Rosenthal, A.3    Schäfer, V.4    Weisenberger, D.5    Carmona Arana, J.A.6
  • 21
    • 77950352082 scopus 로고    scopus 로고
    • Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation
    • doi:10.1016/j.molcel.2010.03.009
    • Zheng C, Kabaleeswaran V, Wang Y, Cheng G, Wu H. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol Cell (2010) 38:101-13. doi:10.1016/j.molcel.2010.03.009.
    • (2010) Mol Cell , vol.38 , pp. 101-113
    • Zheng, C.1    Kabaleeswaran, V.2    Wang, Y.3    Cheng, G.4    Wu, H.5
  • 22
    • 0345791504 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation
    • doi:10.1074/jbc.M310969200
    • Fotin-Mleczek M, Henkler F, Hausser A, Glauner H, Samel D, Graness A, et al. Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation. J Biol Chem (2004) 279:677-85. doi:10.1074/jbc.M310969200.
    • (2004) J Biol Chem , vol.279 , pp. 677-685
    • Fotin-Mleczek, M.1    Henkler, F.2    Hausser, A.3    Glauner, H.4    Samel, D.5    Graness, A.6
  • 23
    • 80054854922 scopus 로고    scopus 로고
    • Non-canonical NF-κB signaling activation and regulation: principles and perspectives
    • doi:10.1111/j.1600-065X.2011.01059.x
    • Razani B, Reichardt AD, Cheng G. Non-canonical NF-κB signaling activation and regulation: principles and perspectives. Immunol Rev (2011) 244:44-54. doi:10.1111/j.1600-065X.2011.01059.x.
    • (2011) Immunol Rev , vol.244 , pp. 44-54
    • Razani, B.1    Reichardt, A.D.2    Cheng, G.3
  • 24
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • doi:10.1126/science.281.5383.1680
    • Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science (1998) 281:1680-3. doi:10.1126/science.281.5383.1680.
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin Jr., A.S.5
  • 25
    • 0032698901 scopus 로고    scopus 로고
    • TRAF1 is a TNF inducible regulator of NF-kappaB activation
    • doi:10.1016/S0014-5793(99)01356-3
    • Carpentier I, Beyaert R. TRAF1 is a TNF inducible regulator of NF-kappaB activation. FEBS Lett (1999) 460:246-50. doi:10.1016/S0014-5793(99)01356-3.
    • (1999) FEBS Lett , vol.460 , pp. 246-250
    • Carpentier, I.1    Beyaert, R.2
  • 26
    • 0033516570 scopus 로고    scopus 로고
    • The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase
    • doi:10.1074/jbc.274.27.19368
    • Schwenzer R, Siemienski K, Liptay S, Schubert G, Peters N, Scheurich P, et al. The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase. J Biol Chem (1999) 274:19368-74. doi:10.1074/jbc.274.27.19368.
    • (1999) J Biol Chem , vol.274 , pp. 19368-19374
    • Schwenzer, R.1    Siemienski, K.2    Liptay, S.3    Schubert, G.4    Peters, N.5    Scheurich, P.6
  • 27
    • 5644302162 scopus 로고    scopus 로고
    • Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase
    • doi:10.1016/j.immuni.2004.08.009
    • Ramakrishnan P, Wang W, Wallach D. Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Immunity (2004) 21:477-89. doi:10.1016/j.immuni.2004.08.009.
    • (2004) Immunity , vol.21 , pp. 477-489
    • Ramakrishnan, P.1    Wang, W.2    Wallach, D.3
  • 28
    • 0033966264 scopus 로고    scopus 로고
    • Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis
    • doi:10.1016/S0014-5793(00)01206-0
    • Irmler M, Steiner V, Ruegg C, Wajant H, Tschopp J. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. FEBS Lett (2000) 468:129-33. doi:10.1016/S0014-5793(00)01206-0.
    • (2000) FEBS Lett , vol.468 , pp. 129-133
    • Irmler, M.1    Steiner, V.2    Ruegg, C.3    Wajant, H.4    Tschopp, J.5
  • 29
    • 0035896644 scopus 로고    scopus 로고
    • TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis
    • doi:10.1074/jbc.M009450200
    • Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, et al. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. J Biol Chem (2001) 276:8087-93. doi:10.1074/jbc.M009450200.
    • (2001) J Biol Chem , vol.276 , pp. 8087-8093
    • Leo, E.1    Deveraux, Q.L.2    Buchholtz, C.3    Welsh, K.4    Matsuzawa, S.5    Stennicke, H.R.6
  • 30
    • 0034803045 scopus 로고    scopus 로고
    • Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death
    • doi:10.1006/bbrc.2001.4369
    • Jang HD, Chung YM, Baik JH, Choi YG, Park IS, Jung YK, et al. Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death. Biochem Biophys Res Commun (2001) 281:499-505. doi:10.1006/bbrc.2001.4369.
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 499-505
    • Jang, H.D.1    Chung, Y.M.2    Baik, J.H.3    Choi, Y.G.4    Park, I.S.5    Jung, Y.K.6
  • 31
    • 8744244173 scopus 로고    scopus 로고
    • Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2
    • doi:10.1002/pmic.200401000
    • Lee JS, Hong US, Lee TH, Yoon SK, Yoon JB. Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2. Proteomics (2004) 4:3376-82. doi:10.1002/pmic.200401000.
    • (2004) Proteomics , vol.4 , pp. 3376-3382
    • Lee, J.S.1    Hong, U.S.2    Lee, T.H.3    Yoon, S.K.4    Yoon, J.B.5
  • 32
    • 84855283949 scopus 로고    scopus 로고
    • Studies of binding of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) to fibroblast growth factor inducible 14 (Fn14)
    • doi:10.1074/jbc.M111.287656
    • Fick A, Lang I, Schäfer V, Seher A, Trebing J, Weisenberger D, et al. Studies of binding of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) to fibroblast growth factor inducible 14 (Fn14). J Biol Chem (2012) 287:484-95. doi:10.1074/jbc.M111.287656.
    • (2012) J Biol Chem , vol.287 , pp. 484-495
    • Fick, A.1    Lang, I.2    Schäfer, V.3    Seher, A.4    Trebing, J.5    Weisenberger, D.6
  • 33
    • 84875138229 scopus 로고    scopus 로고
    • The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors
    • doi:10.1371/journal.pone.0059292
    • Rauert-Wunderlich H, Siegmund D, Maier E, Giner T, Bargou RC, Wajant H, et al. The IKK inhibitor Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors. PLoS One (2013) 8:e59292. doi:10.1371/journal.pone.0059292.
    • (2013) PLoS One , vol.8
    • Rauert-Wunderlich, H.1    Siegmund, D.2    Maier, E.3    Giner, T.4    Bargou, R.C.5    Wajant, H.6
  • 34
    • 64749098830 scopus 로고    scopus 로고
    • An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
    • doi:10.1038/nature07884
    • Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature (2009) 458:732-6. doi:10.1038/nature07884.
    • (2009) Nature , vol.458 , pp. 732-736
    • Soucy, T.A.1    Smith, P.G.2    Milhollen, M.A.3    Berger, A.J.4    Gavin, J.M.5    Adhikari, S.6
  • 35
    • 84856641109 scopus 로고    scopus 로고
    • NF-κB, the first quarter-century: remarkable progress and outstanding questions
    • doi:10.1101/gad.183434.111
    • Hayden MS, Ghosh S. NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 26:203-34. doi:10.1101/gad.183434.111.
    • (2012) Genes Dev , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 36
    • 0032818286 scopus 로고    scopus 로고
    • Structure of the murine TRAF1 gene
    • doi:10.1016/S0161-5890(99)00075-9
    • Dunn IF, Geha RS, Tsitsikov EN. Structure of the murine TRAF1 gene. Mol Immunol (1999) 36:611-7. doi:10.1016/S0161-5890(99)00075-9.
    • (1999) Mol Immunol , vol.36 , pp. 611-617
    • Dunn, I.F.1    Geha, R.S.2    Tsitsikov, E.N.3
  • 37
    • 34547138171 scopus 로고    scopus 로고
    • NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis
    • doi:10.1182/blood-2006-11-058446
    • Zhang B, Wang Z, Li T, Tsitsikov EN, Ding HF. NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis. Blood (2007) 110:743-51. doi:10.1182/blood-2006-11-058446.
    • (2007) Blood , vol.110 , pp. 743-751
    • Zhang, B.1    Wang, Z.2    Li, T.3    Tsitsikov, E.N.4    Ding, H.F.5
  • 38
    • 33645785083 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity
    • Sánchez-Valdepeñas C, Martín AG, Ramakrishnan P, Wallach D, Fresno M. NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity. J Immunol (2006) 176:4666-74.
    • (2006) J Immunol , vol.176 , pp. 4666-4674
    • Sánchez-Valdepeñas, C.1    Martín, A.G.2    Ramakrishnan, P.3    Wallach, D.4    Fresno, M.5
  • 39
    • 0037497184 scopus 로고    scopus 로고
    • A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression
    • doi:10.1038/nature01648
    • Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature (2003) 423:659-63. doi:10.1038/nature01648.
    • (2003) Nature , vol.423 , pp. 659-663
    • Anest, V.1    Hanson, J.L.2    Cogswell, P.C.3    Steinbrecher, K.A.4    Strahl, B.D.5    Baldwin, A.S.6
  • 40
    • 0038511129 scopus 로고    scopus 로고
    • Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
    • doi:10.1038/nature01576
    • Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature (2003) 423:655-9. doi:10.1038/nature01576.
    • (2003) Nature , vol.423 , pp. 655-659
    • Yamamoto, Y.1    Verma, U.N.2    Prajapati, S.3    Kwak, Y.T.4    Gaynor, R.B.5
  • 41
    • 33846323310 scopus 로고    scopus 로고
    • A fourth IkappaB protein within the NF-kappaB signaling module
    • doi:10.1016/j.cell.2006.12.033
    • Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, et al. A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 128:369-81. doi:10.1016/j.cell.2006.12.033.
    • (2007) Cell , vol.128 , pp. 369-381
    • Basak, S.1    Kim, H.2    Kearns, J.D.3    Tergaonkar, V.4    O'Dea, E.5    Werner, S.L.6
  • 42
    • 79952498248 scopus 로고    scopus 로고
    • TNFR1-induced activation of the classical NF-κB pathway
    • doi:10.1111/j.1742-4658.2011.08015.x
    • Wajant H, Scheurich P. TNFR1-induced activation of the classical NF-κB pathway. FEBS J (2011) 278:862-76. doi:10.1111/j.1742-4658.2011.08015.x.
    • (2011) FEBS J , vol.278 , pp. 862-876
    • Wajant, H.1    Scheurich, P.2
  • 43
    • 65049086930 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation
    • doi:10.1038/onc.2009.29
    • Wicovsky A, Henkler F, Salzmann S, Scheurich P, Kneitz C, Wajant H. Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. Oncogene (2009) 28:1769-81. doi:10.1038/onc.2009.29.
    • (2009) Oncogene , vol.28 , pp. 1769-1781
    • Wicovsky, A.1    Henkler, F.2    Salzmann, S.3    Scheurich, P.4    Kneitz, C.5    Wajant, H.6
  • 44
    • 84858337114 scopus 로고    scopus 로고
    • Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL-and CD95-mediated apoptosis of glioblastoma cells
    • doi:10.1038/onc.2011.333
    • Jennewein C, Karl S, Baumann B, Micheau O, Debatin KM, Fulda S. Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL-and CD95-mediated apoptosis of glioblastoma cells. Oncogene (2012) 31:1468-74. doi:10.1038/onc.2011.333.
    • (2012) Oncogene , vol.31 , pp. 1468-1474
    • Jennewein, C.1    Karl, S.2    Baumann, B.3    Micheau, O.4    Debatin, K.M.5    Fulda, S.6
  • 45
    • 68149156979 scopus 로고    scopus 로고
    • Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand
    • doi:10.4049/jimmunol.0802597
    • Wyzgol A, Müller N, Fick A, Munkel S, Grigoleit GU, Pfizenmaier K, et al. Trimer stabilization, oligomerization, and antibody-mediated cell surface immobilization improve the activity of soluble trimers of CD27L, CD40L, 41BBL, and glucocorticoid-induced TNF receptor ligand. J Immunol (2009) 183:1851-61. doi:10.4049/jimmunol.0802597.
    • (2009) J Immunol , vol.183 , pp. 1851-1861
    • Wyzgol, A.1    Müller, N.2    Fick, A.3    Munkel, S.4    Grigoleit, G.U.5    Pfizenmaier, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.