Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection

Brazilian Journal of Infectious Diseases

Volumn 18, Issue 2, 2014, Pages 220-224

  Guardia, Ana Carolina ^a   Stucchi, Raquel Silveira Bello ^a   Milan, Arlete ^a   Costa, Sandra Cecília Botelho ^a   Boin, Ilka de Fátima Santana Ferreira ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Cytomegalovirus; Human herpesvirus 6; Liver donor biopsies; Liver transplantation

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA DR ANTIGEN; HLA DR15 ANTIGEN; VIRUS DNA; HLA ANTIGEN;

ACUTE GRAFT REJECTION; ARTICLE; CLINICAL ARTICLE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; DNA DETERMINATION; FEMALE; HERPES VIRUS INFECTION; HLA MATCHING; HUMAN; HUMAN HERPESVIRUS 6; HUMAN TISSUE; LIVER BIOPSY; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MALE; VIRUS REACTIVATION; ADULT; BIOCOMPATIBILITY; CADAVER DONOR; CONTROLLED STUDY; GRAFT RECIPIENT; HIGH RISK POPULATION; MAJOR CLINICAL STUDY; NONHUMAN; ORGAN DONOR; POLYMERASE CHAIN REACTION; VIRUS LOAD;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 6; LIVER DONOR BIOPSIES; LIVER TRANSPLANTATION;

ACUTE DISEASE; ADULT; BIOPSY; COHORT STUDIES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; FEMALE; GRAFT REJECTION; HERPESVIRUS 6, HUMAN; HLA-DR ANTIGENS; HUMANS; LIVER; LIVER TRANSPLANTATION; MALE; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; ROSEOLOVIRUS INFECTIONS; VIRUS ACTIVATION;

EID: 84897655215     PISSN: 14138670     EISSN: 16784391     Source Type: Journal    
DOI: 10.1016/j.bjid.2013.07.007     Document Type: Article

References (20)

1. Cope A.V., Sabin C., Burroughs A., et al. Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood, donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation. J Infect Dis 1997, 176:1484-1490.
2. Razonable R.R., Lautenschlager I. Impact of human herpes virus 6 in liver transplantation. World J Hepatol 2010, 2:345-353.
3. Beam E., Razonable R.R. Cytomegalovirus in solid organ transplantation: epidemiology, prevention, and treatment. Curr Infect Dis Rep 2012, 14:633-641.
4. Manez R., White L.T., Linden P., et al. The influence of HLA matching on cytomegalovirus hepatitis and chronic rejection after liver transplantation. Transplantation 1993, 55:1067-1071.
5. Seehofer D., Rayes N., Tullius S.G., et al. CMV hepatitis after liver transplantation: incidence, clinical course, and long-term follow-up. Liver Transpl 2002, 8:1138-1146.
6. Lan X., Zhang M.M., Pu C.L., et al. Impact of human leukocyte antigen mismatching on outcomes of liver transplantation: a meta-analysis. World J Gastroenterol 2010, 16:3457-3464.
7. Guardia A.C., Stucchi R.S., Sampaio A.M., et al. Human herpesvirus 6 in donor biopsies associated with the incidence of clinical cytomegalovirus disease and hepatitis C virus recurrence. Int J Infect Dis 2012, 16:124-129.
8. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997, 25:658-663.
9. Shibata D., Martin W.J., Appleman M.D., et al. Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis 1988, 158:1185-1192.
10. Secchiero P., Carrigan D.R., Asano Y., et al. Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. J Infect Dis 1995, 171:273-280.
11. Guardia-Silva A.C., Stucchi R.S., Sampaio A.M., et al. Detection of cytomegalovirus and human herpesvirus-6 DNA in liver biopsy specimens and their correlation with rejection after liver transplantation. Transplant Proc 2012, 44:2441-2444.
12. Sampaio A.M., Guardia A.C., Milan A., et al. Co-infection and clinical impact of human herpesvirus 5 and 6 in liver transplantation. Transplant Proc 2012, 44:2455-2458.
13. Milan A., Sampaio A.M., Guardia A.C., et al. Monitoring and detection of cytomegalovirus in liver transplant recipients. Transplant Proc 2011, 43:1360-1361.
14. Abdel Massih R.C., Razonable R.R. Human herpesvirus 6 infections after liver transplantation. World J Gastroenterol 2009, 15:2561-2569.
15. Humar A., Kumar D., Raboud J., et al. Interactions between cytomegalovirus, human herpesvirus-6, and the recurrence of hepatitis C after liver transplantation. Am J Transplant 2002, 2:461-466.
16. Krueger G.R., Klueppenberg U., Hoffman A., et al. Clinical correlates of infection with human herpesvirus-6. In Vivo 1994, 8:457-516.
17. De Bolle L., Naesens L., De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 2005, 18:217-245.
18. Pischke S., Gösling J., Engelmann I., et al. High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis. J Hepatol 2012, 56:1063-1069.
19. Hu J., Meng X., Zhao H., et al. Association of human cytomegalovirus viremia with human leukocyte antigens in liver transplantation recipients. Acta Biochim Biophys Sin (Shanghai) 2011, 43:576-581.
20. Donaldson P., Underhill J., Doherty D., et al. Influence of human leucocytes antigen matching on liver allograft survival and rejection: 'the dualistic effect'. Hepatology 1993, 17:1008-1015.