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Volumn 14, Issue 6, 2012, Pages 633-641

Cytomegalovirus in solid organ transplantation: Epidemiology, prevention, and treatment

Author keywords

Antiviral prophylaxis; Cytomegalovirus; Epidemiology; Immunologic monitoring; Preemptive therapy; Prevention strategies; Solid organ transplant

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; CYTOMEGALOVIRUS ANTIGEN PP65; GANCICLOVIR; VALACICLOVIR; VALGANCICLOVIR;

EID: 84870501968     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-012-0292-2     Document Type: Review
Times cited : (111)

References (39)
  • 1
  • 2
    • 84859499648 scopus 로고    scopus 로고
    • Post-renal transplant cytomegalovirus infection: Study of risk factors
    • Kute VB, Vanikar AV, Shah PR, et al. Post-renal transplant cytomegalovirus infection: study of risk factors. Transplant Proc. 2012;44(3):706.
    • (2012) Transplant Proc , vol.44 , Issue.3 , pp. 706
    • Kute, V.B.1    Vanikar, A.V.2    Shah, P.R.3
  • 3
    • 80051683456 scopus 로고    scopus 로고
    • Influence of cytomegalovirus disease in outcome of solid organ transplant patients
    • Linares L, Sanclemente G, Cervera C, et al. Influence of cytomegalovirus disease in outcome of solid organ transplant patients. Transplant Proc. 2011;43(6):2145.
    • (2011) Transplant Proc , vol.43 , Issue.6 , pp. 2145
    • Linares, L.1    Sanclemente, G.2    Cervera, C.3
  • 4
    • 79953189057 scopus 로고    scopus 로고
    • Is cytomegalovirus infection dangerous in cytomegalovirus-seropositive recipients after liver transplantation?
    • Kim JM, Kim SJ, Joh JW, et al. Is cytomegalovirus infection dangerous in cytomegalovirus-seropositive recipients after liver transplantation? Liver Transplant: AASLD Int Liver Transplant Soc. 2011;17(4):446.
    • (2011) Liver Transplant: AASLD Int Liver Transplant Soc , vol.17 , Issue.4 , pp. 446
    • Kim, J.M.1    Kim, S.J.2    Joh, J.W.3
  • 5
    • 80053319207 scopus 로고    scopus 로고
    • Association of cytomegalovirus infection and disease with death and graft loss after liver transplant in high-risk recipients
    • A large single-center retrospective study describing the significant association between CMV disease and graft failure and death after liver transplantation
    • Bosch W, Heckman MG, Diehl NN, Shalev JA, Pungpapong S, Hellinger WC. Association of cytomegalovirus infection and disease with death and graft loss after liver transplant in high-risk recipients. Am J Transplant: American Soc Transplant American Soc Transplant Surg. 2011;11(10):2181. A large single-center retrospective study describing the significant association between CMV disease and graft failure and death after liver transplantation.
    • (2011) Am J Transplant: American Soc Transplant American Soc Transplant Surg , vol.11 , Issue.10 , pp. 2181
    • Bosch, W.1    Heckman, M.G.2    Diehl, N.N.3    Shalev, J.A.4    Pungpapong, S.5    Hellinger, W.C.6
  • 6
    • 80055000265 scopus 로고    scopus 로고
    • Epidemiology of cytomegalovirus infection after pancreas transplantation
    • Parsaik AK, Bhalla T, Dong M, et al. Epidemiology of cytomegalovirus infection after pancreas transplantation. Transplantation. 2011;92(9):1044.
    • (2011) Transplantation , vol.92 , Issue.9 , pp. 1044
    • Parsaik, A.K.1    Bhalla, T.2    Dong, M.3
  • 7
    • 84859485906 scopus 로고    scopus 로고
    • Cytomegalovirus disease in kidney transplant recipients: Incidence, clinical profile, and risk factors
    • Cordero E, Casasola C, Ecarma R, Danguilan R. Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors. Transplant Proc. 2012;44(3):694.
    • (2012) Transplant Proc , vol.44 , Issue.3 , pp. 694
    • Cordero, E.1    Casasola, C.2    Ecarma, R.3    Danguilan, R.4
  • 8
    • 79958010182 scopus 로고    scopus 로고
    • Risk factors for late-onset cytomegalovirus disease in donor seropositive/recipient seronegative kidney transplant recipients who receive antiviral prophylaxis
    • Boudreault AA, Xie H, Rakita RM, et al. Risk factors for late-onset cytomegalovirus disease in donor seropositive/recipient seronegative kidney transplant recipients who receive antiviral prophylaxis. Transpl Infect Dis. 2011;13(3):244.
    • (2011) Transpl Infect Dis , vol.13 , Issue.3 , pp. 244
    • Boudreault, A.A.1    Xie, H.2    Rakita, R.M.3
  • 9
    • 84857194014 scopus 로고    scopus 로고
    • Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: pooled analysis of three clinical trials
    • A retrospective review of three pooled clinical trials demonstrating the lower risk of CMV infection in patients receiving everolimus, as compared with mycophenolic acid, as part of the immunosuppressive regimen
    • Brennan DC, Legendre C, Patel D, et al. Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: pooled analysis of three clinical trials. Am J Transplant. 2011;11(11):2453. A retrospective review of three pooled clinical trials demonstrating the lower risk of CMV infection in patients receiving everolimus, as compared with mycophenolic acid, as part of the immunosuppressive regimen.
    • (2011) Am J Transplant , vol.11 , Issue.11 , pp. 2453
    • Brennan, D.C.1    Legendre, C.2    Patel, D.3
  • 10
    • 84863012906 scopus 로고    scopus 로고
    • Homozygosity for the toll-like receptor 2 r753q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation
    • A novel observation that defects in innate immune response is a risk factor for the development of CMV disease in transplant recipients
    • Kang SH, Abdel-Massih RC, Brown RA, Dierkhising RA, Kremers WK, Razonable RR. Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation. J Infect Dis. 2012;205(4):639. A novel observation that defects in innate immune response is a risk factor for the development of CMV disease in transplant recipients.
    • (2012) J Infect Dis , vol.205 , Issue.4 , pp. 639
    • Kang, S.H.1    Abdel-Massih, R.C.2    Brown, R.A.3    Dierkhising, R.A.4    Kremers, W.K.5    Razonable, R.R.6
  • 11
    • 84855848791 scopus 로고    scopus 로고
    • Clinical utility of cytomegalovirus cell-mediated immunity in transplant recipients with cytomegalovirus viremia
    • This study highlights the importance of immunity in the control of CMV infection after transplantation
    • Lisboa LF, Kumar D, Wilson LE, Humar A. Clinical utility of cytomegalovirus cell-mediated immunity in transplant recipients with cytomegalovirus viremia. Transplantation. 2012;93(2):195. This study highlights the importance of immunity in the control of CMV infection after transplantation.
    • (2012) Transplantation , vol.93 , Issue.2 , pp. 195
    • Lisboa, L.F.1    Kumar, D.2    Wilson, L.E.3    Humar, A.4
  • 12
    • 77950926374 scopus 로고    scopus 로고
    • International consensus guidelines on the management of cytomegalovirus in solid organ transplantation
    • This article serves as the document of a consensus developed by experts in the management of CMV in solid organ transplant recipients
    • Kotton CN, Kumar D, CaliendoAM, et al. International consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation. 2010;89(7):779. This article serves as the document of a consensus developed by experts in the management of CMV in solid organ transplant recipients.
    • (2010) Transplantation , vol.89 , Issue.7 , pp. 779
    • Kotton, C.N.1    Kumar, D.2    Caliendo, A.M.3
  • 13
    • 79958755778 scopus 로고    scopus 로고
    • Comparison of real-Time pcr and pp65 antigen assays for monitoring the development of cytomegalovirus disease in recipients of solid organ and bone marrow transplants
    • Marchetti S, Santangelo R, Manzara S, D'Onghia S, Fadda G, Cattani P. Comparison of real-Time PCR and pp65 antigen assays for monitoring the development of Cytomegalovirus disease in recipients of solid organ and bone marrow transplants. New Microbiol. 2011;34(2):157.
    • (2011) New Microbiol , vol.34 , Issue.2 , pp. 157
    • Marchetti, S.1    Santangelo, R.2    Manzara, S.3    D'Onghia, S.4    Fadda, G.5    Cattani, P.6
  • 14
    • 80052710216 scopus 로고    scopus 로고
    • Clinical usefulness of plasma quantitative polymerase chain reaction assay: Diagnosis of cytomegalovirus infection in kidney transplant recipients
    • Rhee JY, Peck KR, Lee NY, Song JH. Clinical usefulness of plasma quantitative polymerase chain reaction assay: diagnosis of cytomegalovirus infection in kidney transplant recipients. Transplant Proc. 2011;43(7):2624.
    • (2011) Transplant Proc , vol.43 , Issue.7 , pp. 2624
    • Rhee, J.Y.1    Peck, K.R.2    Lee, N.Y.3    Song, J.H.4
  • 15
    • 78751646736 scopus 로고    scopus 로고
    • The clinical utility of whole blood versus plasma cytomegalovirus viral load assays for monitoring therapeutic response
    • Lisboa LF, Asberg A, Kumar D, et al. The clinical utility of whole blood versus plasma cytomegalovirus viral load assays for monitoring therapeutic response. Transplantation. 2011;91(2):231.
    • (2011) Transplantation , vol.91 , Issue.2 , pp. 231
    • Lisboa, L.F.1    Asberg, A.2    Kumar, D.3
  • 16
    • 79960041597 scopus 로고    scopus 로고
    • Comparison of the results of quantitative polymerase chain reaction for cytomegalovirus among laboratories
    • Mori T, Kato J, Yamane A, Aisa Y, Nakazato T, Okamoto S. Comparison of the results of quantitative polymerase chain reaction for cytomegalovirus among laboratories. JPN J Clin Hematol. 2011;52(4):204.
    • (2011) JPN J Clin Hematol , vol.52 , Issue.4 , pp. 204
    • Mori, T.1    Kato, J.2    Yamane, A.3    Aisa, Y.4    Nakazato, T.5    Okamoto, S.6
  • 17
    • 84856164819 scopus 로고    scopus 로고
    • Factors contributing to variability of quantitative viral pcr results in proficiency testing samples: A multivariate analysis
    • This article highlights the various factors that contribute to the variability in the viral load reporting among clinical laboratories
    • Hayden RT, Yan X, Wick MT, et al. Factors contributing to variability of quantitative viral PCR results in proficiency testing samples: a multivariate analysis. J Clin Microbiol. 2012;50 (2):337. This article highlights the various factors that contribute to the variability in the viral load reporting among clinical laboratories.
    • (2012) J Clin Microbiol , vol.50 , Issue.2 , pp. 337
    • Hayden, R.T.1    Yan, X.2    Wick, M.T.3
  • 19
    • 84860346013 scopus 로고    scopus 로고
    • Performance of the quantiferon-cytomegalovirus (cmv) assay for detection and estimation of the magnitude and functionality of the cmvspecific gamma interferon-producing cd8(+) t-cell response in allogeneic stem cell transplant recipients
    • Clari MA, Munoz-Cobo B, Solano C, et al. Performance of the QuantiFERON-cytomegalovirus (CMV) assay for detection and estimation of the magnitude and functionality of the CMVspecific gamma interferon-producing CD8(+) T-cell response in allogeneic stem cell transplant recipients. Clin Vaccine Immunol. 2012;19(5):791.
    • (2012) Clin Vaccine Immunol , vol.19 , Issue.5 , pp. 791
    • Clari, M.A.1    Munoz-Cobo, B.2    Solano, C.3
  • 20
    • 78650565328 scopus 로고    scopus 로고
    • Quantiferon(r)-cmv assay for the assessment of cytomegalovirus cell-mediated immunity
    • Giulieri S, Manuel O. QuantiFERON(R)-CMV assay for the assessment of cytomegalovirus cell-mediated immunity. Expert Rev Mol Diagn. 2011;11(1):17.
    • (2011) Expert Rev Mol Diagn , vol.11 , Issue.1 , pp. 17
    • Giulieri, S.1    Manuel, O.2
  • 21
    • 79951822463 scopus 로고    scopus 로고
    • Effectiveness of valganciclovir 900 mg versus 450 mg for cytomegalovirus prophylaxis in transplantation: Direct and indirect treatment comparison meta-Analysis
    • Kalil AC, Mindru C, Florescu DF. Effectiveness of valganciclovir 900 mg versus 450 mg for cytomegalovirus prophylaxis in transplantation: direct and indirect treatment comparison meta-Analysis. Clin Infect Dis. 2011;52(3):313.
    • (2011) Clin Infect Dis , vol.52 , Issue.3 , pp. 313
    • Kalil, A.C.1    Mindru, C.2    Florescu, D.F.3
  • 22
    • 79953864833 scopus 로고    scopus 로고
    • Update and review: State-of-The-Art management of cytomegalovirus infectionand disease following thoracic organ transplantation
    • Snydman DR, Limaye AP, Potena L, Zamora MR. Update and review: state-of-The-Art management of cytomegalovirus infectionand disease following thoracic organ transplantation. Transplant Proc. 2011;43(3 Suppl):S1.
    • (2011) Transplant Proc , vol.43 , Issue.3 SUPPL.
    • Snydman, D.R.1    Limaye, A.P.2    Potena, L.3    Zamora, M.R.4
  • 23
    • 1942469969 scopus 로고    scopus 로고
    • Efficacy and safety of valganciclovir vs. Oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients
    • Paya C, Humar A, Dominguez E, et al. Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant. 2004;4(4):611.
    • (2004) Am J Transplant , vol.4 , Issue.4 , pp. 611
    • Paya, C.1    Humar, A.2    Dominguez, E.3
  • 24
    • 77950468641 scopus 로고    scopus 로고
    • The efficacy and safety of 200 days valganciclovir cytomegalovirus prophylaxis in highrisk kidney transplant recipients
    • Humar A, Lebranchu Y, Vincenti F, et al. The efficacy and safety of 200 days valganciclovir cytomegalovirus prophylaxis in highrisk kidney transplant recipients. Am J Transplant. 2010;10(5):1228.
    • (2010) Am J Transplant , vol.10 , Issue.5 , pp. 1228
    • Humar, A.1    Lebranchu, Y.2    Vincenti, F.3
  • 25
    • 78650819624 scopus 로고    scopus 로고
    • Extended valganciclovir prophylaxis in d+/r-kidney transplant recipients is associated with long-Term reduction in cytomegalovirus disease: Two-year results of the impact study
    • Humar A, Limaye AP, Blumberg EA, et al. Extended valganciclovir prophylaxis in D+/R-kidney transplant recipients is associated with long-Term reduction in cytomegalovirus disease: two-year results of the IMPACT study. Transplantation. 2010;90(12):1427.
    • (2010) Transplantation , vol.90 , Issue.12 , pp. 1427
    • Humar, A.1    Limaye, A.P.2    Blumberg, E.A.3
  • 26
    • 77954070106 scopus 로고    scopus 로고
    • Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: A randomized, controlled trial
    • A prospective randomized multicenter clinical trial showing that extending CMV prophylaxis in lung transplant patients from 3 to 12 months resulted in significant decrease of development of CMV disease
    • Palmer SM, Limaye AP, Banks M, et al. Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial. Ann Intern Med. 2010;152(12):761. A prospective randomized multicenter clinical trial showing that extending CMV prophylaxis in lung transplant patients from 3 to 12 months resulted in significant decrease of development of CMV disease.
    • (2010) Ann Intern Med , vol.152 , Issue.12 , pp. 761
    • Palmer, S.M.1    Limaye, A.P.2    Banks, M.3
  • 27
    • 80051469766 scopus 로고    scopus 로고
    • Long-Term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: A singlecenter, long-Term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial
    • Finlen Copeland CA, Davis WA, Snyder LD, et al. Long-Term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: a singlecenter, long-Term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial. J Heart Lung Transplant. 2011;30 (9):990.
    • (2011) J Heart Lung Transplant , vol.30 , Issue.9 , pp. 990
    • Finlen Copeland, C.A.1    Davis, W.A.2    Snyder, L.D.3
  • 28
    • 84863398725 scopus 로고    scopus 로고
    • Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis
    • A single-center observational study of planned indefinite valganciclovir prophylaxis in lung transplant recipients showing a 50% rate of discontinuation of prophylaxis mainly due to leukopenia
    • Wiita AP, Roubinian N, Khan Y, et al. Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis. Transplant infectious disease. 2012. A single-center observational study of planned indefinite valganciclovir prophylaxis in lung transplant recipients showing a 50% rate of discontinuation of prophylaxis mainly due to leukopenia.
    • (2012) Transplant infectious disease
    • Wiita, A.P.1    Roubinian, N.2    Khan, Y.3
  • 29
    • 84655163830 scopus 로고    scopus 로고
    • Valganciclovir prophylaxis versus preemptive therapy in cytomegalovirus-positive renal allograft recipients: 1-year results of a randomized clinical trial
    • A prospective randomized clinical trial in renal transplant recipients comparing preventive with prophylaxis strategy, with results showing that prophylaxis with valganciclovir significantly reduced that rate of CMV infection and disease
    • Witzke O, Hauser IA, Bartels M, Wolf G, Wolters H, Nitschke M. Valganciclovir prophylaxis versus preemptive therapy in cytomegalovirus-positive renal allograft recipients: 1-year results of a randomized clinical trial. Transplantation. 2012;93(1):61. A prospective randomized clinical trial in renal transplant recipients comparing preventive with prophylaxis strategy, with results showing that prophylaxis with valganciclovir significantly reduced that rate of CMV infection and disease.
    • (2012) Transplantation , vol.93 , Issue.1 , pp. 61
    • Witzke, O.1    Hauser, I.A.2    Bartels, M.3    Wolf, G.4    Wolters, H.5    Nitschke, M.6
  • 30
    • 84856869951 scopus 로고    scopus 로고
    • Antibody-dependent anticytomegalovirus activity of human gammadelta t cells expressing cd16 (fcgammariiia
    • Couzi L, Pitard V, Sicard X, et al. Antibody-dependent anticytomegalovirus activity of human gammadelta T cells expressing CD16 (FcgammaRIIIa). Blood. 2012;119(6):1418.
    • (2012) Blood , vol.119 , Issue.6 , pp. 1418
    • Couzi, L.1    Pitard, V.2    Sicard, X.3
  • 31
    • 80055015760 scopus 로고    scopus 로고
    • Clinical utility of molecular surveillance for cytomegalovirus after antiviral prophylaxis in high-risk solid organ transplant recipients
    • Lisboa LF, Preiksaitis JK, Humar A, Kumar D. Clinical utility of molecular surveillance for cytomegalovirus after antiviral prophylaxis in high-risk solid organ transplant recipients. Transplantation. 2011;92(9):1063.
    • (2011) Transplantation , vol.92 , Issue.9 , pp. 1063
    • Lisboa, L.F.1    Preiksaitis, J.K.2    Humar, A.3    Kumar, D.4
  • 32
    • 34547829434 scopus 로고    scopus 로고
    • Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients
    • Asberg A, Humar A, Rollag H, et al. Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant. 2007;7(9):2106.
    • (2007) Am J Transplant , vol.7 , Issue.9 , pp. 2106
    • Asberg, A.1    Humar, A.2    Rollag, H.3
  • 33
    • 80755135410 scopus 로고    scopus 로고
    • The risk of cytomegalovirus recurrence after kidney transplantation
    • Helantera I, Lautenschlager I, Koskinen P. The risk of cytomegalovirus recurrence after kidney transplantation. Transpl Int. 2011;24 (12):1170.
    • (2011) Transpl Int , vol.24 , Issue.12 , pp. 1170
    • Helantera, I.1    Lautenschlager, I.2    Koskinen, P.3
  • 34
    • 78049355534 scopus 로고    scopus 로고
    • Antiviral drug resistance of human cytomegalovirus
    • Lurain NS, Chou S. Antiviral drug resistance of human cytomegalovirus. Clin Microbiol Rev. 2010;23(4):689.
    • (2010) Clin Microbiol Rev , vol.23 , Issue.4 , pp. 689
    • Lurain, N.S.1    Chou, S.2
  • 35
    • 79960309676 scopus 로고    scopus 로고
    • Incidence and outcomes of ganciclovir-resistant cytomegalovirus infections in 1244 kidney transplant recipients
    • Myhre HA, Haug Dorenberg D, Kristiansen KI, et al. Incidence and outcomes of ganciclovir-resistant cytomegalovirus infections in 1244 kidney transplant recipients. Transplantation. 2011;92 (2):217.
    • (2011) Transplantation , vol.92 , Issue.2 , pp. 217
    • Myhre, H.A.1    Haug Dorenberg, D.2    Kristiansen, K.I.3
  • 36
    • 84856970327 scopus 로고    scopus 로고
    • Incidence of cytomegalovirus ul97 and ul54 amino acid substitutions detected after 100 or 200 days of valganciclovir prophylaxis
    • Boivin G, Goyette N, Farhan M, Ives J, Elston R. Incidence of cytomegalovirus UL97 and UL54 amino acid substitutions detected after 100 or 200 days of valganciclovir prophylaxis. J Clin Virol. 2012;53(3).
    • (2012) J Clin Virol , vol.53 , pp. 3
    • Boivin, G.1    Goyette, N.2    Farhan, M.3    Ives, J.4    Elston, R.5
  • 37
    • 79955544310 scopus 로고    scopus 로고
    • First report of successful treatment of multidrug-resistant cytomegalovirus disease with the novel anti-cmv compound aic246
    • Kaul DR, Stoelben S, Cober E, et al. First report of successful treatment of multidrug-resistant cytomegalovirus disease with the novel anti-CMV compound AIC246. Am J Transplant. 2011;11 (5):1079.
    • (2011) Am J Transplant , vol.11 , Issue.5 , pp. 1079
    • Kaul, D.R.1    Stoelben, S.2    Cober, E.3
  • 38
    • 79953743926 scopus 로고    scopus 로고
    • Cytomegalovirus glycoprotein-b vaccine with mf59 adjuvant in transplant recipients: A phase 2 randomised placebo-controlled trial
    • This study provides promising data regarding the potential clinical utility of a vaccine for the prevention of CMV disease in transplant recipients
    • Griffiths PD, Stanton A, McCarrell E, et al. Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trial. Lancet. 2011;377(9773):1256. This study provides promising data regarding the potential clinical utility of a vaccine for the prevention of CMV disease in transplant recipients.
    • (2011) Lancet , vol.377 , Issue.9773 , pp. 1256
    • Griffiths, P.D.1    Stanton, A.2    McCarrell, E.3
  • 39
    • 84859007690 scopus 로고    scopus 로고
    • A novel therapeutic cytomegalovirus dna vaccine in allogeneic haemopoietic stem-cell transplantation: A randomised, double-blind, placebocontrolled, phase 2 trial
    • Kharfan-Dabaja MA, Boeckh M, Wilck MB, et al. A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebocontrolled, phase 2 trial. Lancet Infect Dis. 2012;12(4):290.
    • (2012) Lancet Infect Dis , vol.12 , Issue.4 , pp. 290
    • Kharfan-Dabaja, M.A.1    Boeckh, M.2    Wilck, M.B.3


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