High intrahepatic HHV-6 virus loads but neither CMV nor EBV are associated with decreased graft survival after diagnosis of graft hepatitis

Journal of Hepatology

Volumn 56, Issue 5, 2012, Pages 1063-1069

  Pischke, Sven ^a,c   Gösling, Juliane ^a,c   Engelmann, Ilka ^a,b   Schlue, Jerome ^a   Wölk, Benno ^a   Jäckel, Elmar ^a   Meyer Heithuis, Christoph ^a   Lehmann, Ulrich ^a   Strassburg, Christian P ^a   Barg Hock, Hannelore ^a   Becker, Thomas ^a   Manns, Michael P ^a   Schulz, Thomas ^a   Wedemeyer, Heiner ^a   Heim, Albert ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b University Lille   (France)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

CMV; EBV; Graft survival; HHV 6; Liver transplantation

Indexed keywords

BILIRUBIN; VIRUS DNA;

ACUTE GRAFT REJECTION; ADULT; AGE; AGED; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; CYTOMEGALOVIRUS; EPSTEIN BARR VIRUS; FEMALE; FOLLOW UP; GRAFT DYSFUNCTION; GRAFT HEPATITIS; GRAFT RECIPIENT; GRAFT SURVIVAL; HEPATITIS; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; LATENT VIRUS INFECTION; LIVER BIOPSY; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; VIRUS DETECTION; VIRUS LOAD;

ADOLESCENT; ADULT; AGED; BIOPSY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HEPATITIS, VIRAL, HUMAN; HERPESVIRUS 4, HUMAN; HERPESVIRUS 6, HUMAN; HUMANS; LIVER; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; ROSEOLOVIRUS INFECTIONS; VIRAL LOAD; VIRUS REPLICATION; YOUNG ADULT;

EID: 84859706631     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.12.017     Document Type: Article

References (38)

1. Seehofer D, Rayes N, Tullius SG, Schmidt CA, Neumann UP, Radke C, et al. CMV hepatitis after liver transplantation: incidence, clinical course, and long-term follow-up. Liver Transpl 2002;8:1138-1146. (Pubitemid 35469875)
2. Barkholt L, Reinholt FP, Teramoto N, Enbom M, Dahl H, Linde A. Polymerase chain reaction and in situ hybridization of Epstein-Barr virus in liver biopsy specimens facilitate the diagnosis of EBV hepatitis after liver transplantation. Transpl Int 1998;11:336-344. (Pubitemid 28427164)
3. Kremers WK, Devarbhavi HC, Wiesner RH, Krom RA, Macon WR, Habermann TM. Post-transplant lymphoproliferative disorders following liver transplantation: incidence, risk factors and survival. Am J Transplant 2006;6:1017-1024. (Pubitemid 44356653)
4. Loginov R, Harma M, Halme L, Hockerstedt K, Lautenschlager I. HHV-6 DNA in peripheral blood mononuclear cells after liver transplantation. J Clin Virol 2006;37 (Suppl. 1):S76-S81.
5. Harma M, Hockerstedt K, Lyytikainen O, Lautenschlager I. HHV-6 and HHV-7 antigenemia related to CMV infection after liver transplantation. J Med Virol 2006;78:800-805.
6. Potenza L, Luppi M, Barozzi P, Rossi G, Cocchi S, Codeluppi M, et al. HHV-6A in syncytial giant-cell hepatitis. N Engl J Med 2008;359:593-602.
7. Humar A, Kumar D, Caliendo AM, Moussa G, Ashi-Sulaiman A, Levy G, et al. Clinical impact of human herpesvirus 6 infection after liver transplantation. Transplantation 2002;73:599-604. (Pubitemid 34193623)
8. Loginov R, Karlsson T, Hockerstedt K, Ablashi D, Lautenschlager I. Quantitative HHV-6B antigenemia test for the monitoring of transplant patients. Eur J Clin Microbiol Infect Dis 2010;29:881-886.
9. Ozaki Y, Tajiri H, Tanaka-Taya K, Mushiake S, Kimoto A, Yamanishi K, et al. Frequent detection of the human herpesvirus 6-specific genomes in the livers of children with various liver diseases. J Clin Microbiol 2001;39:2173-2177. (Pubitemid 32531477)
10. Razonable RR, Paya CV. The impact of human herpesvirus-6 and -7 infection on the outcome of liver transplantation. Liver Transpl 2002;8:651-658.
11. Kangro HO, Osman HK, Lau YL, Heath RB, Yeung CY, Ng MH. Seroprevalence of antibodies to human herpesviruses in England and Hong Kong. J Med Virol 1994;43:91-96. (Pubitemid 24146351)
12. Staras SA, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis 2006;43:1143-1151. (Pubitemid 44632796)
13. Krueger GR, Koch B, Leyssens N, Berneman Z, Rojo J, Horwitz C, et al. Comparison of seroprevalences of human herpesvirus-6 and -7 in healthy blood donors from nine countries. Vox Sang 1998;75:193-197. (Pubitemid 28528705)
14. Timbury MC, Edmond E. Herpesviruses. J Clin Pathol 1979;32:859-881. (Pubitemid 10249448)
15. Ganzenmueller T, Henke-Gendo C, Schlue J, Wedemeyer J, Huebner S, Heim A. Quantification of cytomegalovirus DNA levels in intestinal biopsies as a diagnostic tool for CMV intestinal disease. J Clin Virol 2009;46:254-258.
16. Beckmann MG, Bahr MJ, Hadem J, Bredt M, Wedemeyer H, Schneider AS, et al. Clinical relevance of transjugular liver biopsy in comparison with percutaneous and laparoscopic liver biopsy. Gastroenterol Res Pract 2009;2009:947014.
17. Schrem H, Till N, Becker T, Bektas H, Manns MP, Strassburg CP, et al. Longterm results after liver transplantation. Chirurg 2008;79:121-129.
18. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 1997;25:658-663.
19. Engelmann I, Petzold DR, Kosinska A, Hepkema BG, Schulz TF, Heim A. Rapid quantitative PCR assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens. J Med Virol 2008;80:467-477. (Pubitemid 351206896)
20. Forstmeyer D, Henke-Gendo C, Brocker V, Wildner O, Heim A. Quantitative temporal and spatial distribution of adenovirus type 2 correlates with disease manifestations and organ failure during disseminated infection. J Med Virol 2008;80:294-297.
21. Lautenschlager I, Harma M, Hockerstedt K, Linnavuori K, Loginov R, Taskinen E. Human herpesvirus-6 infection is associated with adhesion molecule induction and lymphocyte infiltration in liver allografts. J Hepatol 2002;37:648-654. (Pubitemid 35305546)
22. Bertelsen LB, Petersen CC, Kofod-Olsen E, Oster B, Hollsberg P, Agger R, et al. Human herpesvirus 6B induces phenotypic maturation without IL-10 and IL- 12p70 production in dendritic cells. Scand J Immunol 2010;71:431-439.
23. Ishikawa K, Hasegawa K, Naritomi T, Kanai N, Ogawa M, Kato Y, et al. Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan. J Gastroenterol 2002;37:523-530.
24. Chevret L, Boutolleau D, Halimi-Idri N, Branchereau S, Baujard C, Fabre M, et al. Human herpesvirus-6 infection: a prospective study evaluating HHV-6 DNA levels in liver from children with acute liver failure. J Med Virol 2008;80:1051-1057. (Pubitemid 351657018)
25. Cermelli C, Concari M, Carubbi F, Fabio G, Sabbatini AM, Pecorari M, et al. Growth of human herpesvirus 6 in HEPG2 cells. Virus Res 1996;45:75-85. (Pubitemid 26317211)
26. Abdel Massih RC, Razonable RR. Human herpesvirus 6 infections after liver transplantation. World J Gastroenterol 2009;15:2561-2569.
27. Ward KN, Leong HN, Nacheva EP, Howard J, Atkinson CE, Davies NW, et al. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J Clin Microbiol 2006;44:1571-1574.
28. Narayanan Menon KV, Nyberg SL, Harmsen WS, DeSouza NF, Rosen CB, Krom RA, et al. MELD and other factors associated with survival after liver transplantation. Am J Transplant 2004;4:819-825. (Pubitemid 38637583)
29. Xu N, Yan LN, Yang JY, Li B, Wen TF, Wang WT, et al. New prognostic model for adult-to-adult living donor liver transplant recipients. Transplant Proc 2011;43:1728-1735.
30. Brandao A, Fuchs SC, Gleisner AL, Marroni C, Zanotelli ML, Cantisani G. MELD and other predictors of survival after liver transplantation. Clin Transplant 2009;23:220-227.
31. Olthoff KM, Kulik L, Samstein B, Kaminski M, Abecassis M, Emond J, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl 2010;16:943-949.
32. Ohashi M, Sugata K, Ihira M, Asano Y, Egawa H, Takada Y, et al. Human herpesvirus 6 infection in adult living related liver transplant recipients. Liver Transpl 2008;14:100-109. (Pubitemid 351167996)
33. Ono Y, Ito Y, Kaneko K, Shibata-Watanabe Y, Tainaka T, Sumida W, et al. Simultaneous monitoring by real-time polymerase chain reaction of epsteinbarr virus, human cytomegalovirus, and human herpesvirus-6 in juvenile and adult liver transplant recipients. Transplant Proc 2008;40:3578-3582.
34. Falagas ME, Paya C, Ruthazer R, Badley A, Patel R, Wiesner R, et al. Significance of cytomegalovirus for long-term survival after orthotopic liver transplantation: a prospective derivation and validation cohort analysis. Transplantation 1998;66:1020-1028. (Pubitemid 28513381)
35. Gao LH, Zheng SS. Cytomegalovirus and chronic allograft rejection in liver transplantation. World J Gastroenterol 2004;10:1857-1861.
36. Falagas ME, Snydman DR, Griffith J, Ruthazer R, Werner BG. Effect of cytomegalovirus infection status on first-year mortality rates among orthotopic liver transplant recipients. The Boston Center for Liver Transplantation CMVIG Study Group. Ann Intern Med 1997;126:275-279. (Pubitemid 27078775)
37. Holmes RD, Orban-Eller K, Karrer FR, Rowe DT, Narkewicz MR, Sokol RJ. Response of elevated Epstein-Barr virus DNA levels to therapeutic changes in pediatric liver transplant patients: 56-month follow-up and outcome. Transplantation 2002;74:367-372.
38. Eing BR, Baumeister HG, Kuehn JE, May G. Long-term persistence of immunoglobulin A (IgA) and IgM antibodies against human cytomegalovirus in solid-organ transplant recipients. Clin Diagn Lab Immunol 1999;6: 621-623. (Pubitemid 29330755)